Faculty Profiles

Katherine J. Franz
Alexander F. Hehmeyer Professor of Chemistry and Department Chair
2103 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1541



Ph.D., Massachusetts Institute of Technology 2000

B.A., Wellesley College 1995

Research Areas:
Biomolecular Structure and Function, Inorganic

Wang, Q, and Franz, KJ. "Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress." Bioorganic & Medicinal Chemistry 26.22 (December 2018): 5962-5972. Full Text

Bakthavatsalam, S, Sleeper, ML, Dharani, A, George, DJ, Zhang, T, and Franz, KJ. "Leveraging γ-Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells." Angewandte Chemie (International Ed. in English) 57.39 (September 2018): 12780-12784. Full Text

Zaengle-Barone, JM, Jackson, AC, Besse, DM, Becken, B, Arshad, M, Seed, PC, and Franz, KJ. "Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria." ACS infectious diseases (March 20, 2018). Full Text

Hall, KC, Franks, AT, McAtee, RC, Wang, MS, Lu, VI, and Franz, KJ. "Metal-binding hydrazone photoswitches for visible light reactivity and variable relaxation kinetics." Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 16.11 (November 2017): 1604-1612. Full Text

Wang, Q, and Franz, KJ. "The hydrolytic susceptibility of prochelator BSIH in aqueous solutions." Bioorganic & Medicinal Chemistry Letters 27.17 (September 2017): 4165-4170. Full Text

Conklin, SE, Bridgman, EC, Su, Q, Riggs-Gelasco, P, Haas, KL, and Franz, KJ. "Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans." Biochemistry 56.32 (August 2017): 4244-4255. Full Text Open Access Copy

Helsel, ME, White, EJ, Razvi, SZA, Alies, B, and Franz, KJ. "Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans." Metallomics : Integrated Biometal Science 9.1 (January 2017): 69-81. Full Text

Wang, Q, and Franz, KJ. "Stimulus-Responsive Prochelators for Manipulating Cellular Metals." Accounts of Chemical Research 49.11 (November 2016): 2468-2477. Full Text

Sansee, A, Meksawangwong, S, Chainok, K, Franz, KJ, Gál, M, Pålsson, L-O, Puniyan, W, Traiphol, R, Pal, R, and Kielar, F. "Novel aminoalkyl tris-cyclometalated iridium complexes as cellular stains." Dalton Transactions (Cambridge, England : 2003) 45.43 (November 2016): 17420-17430. Full Text

Hašková, P, Jansová, H, Bureš, J, Macháček, M, Jirkovská, A, Franz, KJ, Kovaříková, P, and Šimůnek, T. "Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury." Toxicology 371 (September 2016): 17-28. Full Text


Wang, Q, and Franz, KJ. "Detection of Metal Ions, Anions and Small Molecules Using Metal Complexes." Inorganic Chemical Biology: Principles, Techniques and Applications. June 23, 2014. 233-274. Full Text