Faculty Profiles

Katherine J. Franz
Professor in the Department of Chemistry
Office: 
2103 French Science Center, 124 Science Drive, Durham, NC 27708
Phone: 
(919) 660-1541

Overview

Education:

Ph.D., Massachusetts Institute of Technology 2000

B.A., Wellesley College 1995

Research Areas:
Biomolecular Structure and Function, Inorganic

Wang, Qin, and Katherine J. Franz. “Stimulus-Responsive Prochelators for Manipulating Cellular Metals.Accounts of Chemical Research, vol. 49, no. 11, Nov. 2016, pp. 2468–77. Epmc, doi:10.1021/acs.accounts.6b00380. Full Text

Hašková, Pavlína, et al. “Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury.Toxicology, vol. 371, Sept. 2016, pp. 17–28. Epmc, doi:10.1016/j.tox.2016.10.004. Full Text

Jansová, Hana, et al. “Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products.Toxicology, vol. 350–352, Mar. 2016, pp. 15–24. Epmc, doi:10.1016/j.tox.2016.03.004. Full Text

Franks, Andrew T., et al. “A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress.Bioorganic & Medicinal Chemistry Letters, vol. 25, no. 21, Nov. 2015, pp. 4843–47. Epmc, doi:10.1016/j.bmcl.2015.06.048. Full Text

Pushie, M. Jake, et al. “Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1.Inorganic Chemistry, vol. 54, no. 17, Sept. 2015, pp. 8544–51. Epmc, doi:10.1021/acs.inorgchem.5b01162. Full Text

Alies, Bruno, et al. “A prochelator peptide designed to use heterometallic cooperativity to enhance metal ion affinity.Chemical Science, vol. 6, no. 6, June 2015, pp. 3606–10. Epmc, doi:10.1039/c5sc00602c. Full Text

Crumbliss, Alvin L., et al. “Preface. Biometals 2014--Proceedings of the 9th International Symposium Biometals 2014 at Duke University, Durham, NC, USA.Biometals, vol. 28, no. 3, June 2015, p. 431. Pubmed, doi:10.1007/s10534-015-9854-8. Full Text

Helsel, Marian E., and Katherine J. Franz. “Pharmacological activity of metal binding agents that alter copper bioavailability.Dalton Transactions (Cambridge, England : 2003), vol. 44, no. 19, May 2015, pp. 8760–70. Epmc, doi:10.1039/c5dt00634a. Full Text

Bureš, Jan, et al. “LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH).Journal of Pharmaceutical and Biomedical Analysis, vol. 105, Feb. 2015, pp. 55–63. Epmc, doi:10.1016/j.jpba.2014.11.044. Full Text

Safi, Rachid, et al. “Copper signaling axis as a target for prostate cancer therapeutics.Cancer Res, vol. 74, no. 20, Oct. 2014, pp. 5819–31. Pubmed, doi:10.1158/0008-5472.CAN-13-3527. Full Text Open Access Copy

Pages

Liu, L. L., and K. J. Franz. “Characterization of metal binding sites in a synthetic phosphorylated alpha-synuclein peptide fragment.Abstracts of Papers of the American Chemical Society, vol. 229, AMER CHEMICAL SOC, 2005, pp. U1080–81.

Franz, Katherine J., et al. “Development of lanthanide-binding peptides as natively expressed protein probes.” Journal of Inorganic Biochemistry, vol. 96, no. 1, Elsevier BV, 2003, pp. 131–131. Crossref, doi:10.1016/s0162-0134(03)80614-1. Full Text

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