Faculty Profiles

Katherine J. Franz
Katherine J. Franz
Chair of the Department of Chemistry
Office: 
2103 French Science Center, 124 Science Drive, Durham, NC 27708
Phone: 
(919) 660-1541
katherine.franz@duke.edu
Franz Research Group
Research Interests: 

Research in the Franz group is involved in elucidating the structural and functional consequences of metal ion coordination in biological systems. We are particularly interested in understanding the coordination chemistry utilized by biology to manage essential yet toxic species like copper and iron. Understanding these principles further guides our development of new chemical tools to manipulate biological metal ion location, speciation, and reactivity for potential therapeutic benefit. We use a combination of synthesis, spectroscopy, and biochemistry in our work. Please visit our group website to learn more about our research.

Overview

Education:

Ph.D., Massachusetts Institute of Technology 2000

B.A., Wellesley College 1995

Research Areas:
Biomolecular Structure and Function, Inorganic

Franz, Katherine J., et al. “Lanthanide-binding tags as versatile protein coexpression probes.” Chembiochem : A European Journal of Chemical Biology, vol. 4, no. 4, Apr. 2003, pp. 265–71. Epmc, doi:10.1002/cbic.200390046. Full Text

Nitz, Mark, et al. “A powerful combinatorial screen to identify high-affinity terbium(III)-binding peptides.” Chembiochem : A European Journal of Chemical Biology, vol. 4, no. 4, Apr. 2003, pp. 272–76. Epmc, doi:10.1002/cbic.200390047. Full Text

Franz, K. J., et al. “Pentacoordinate cobalt(III) thiolate and nitrosyl tropocoronand compounds.” Inorganic Chemistry, vol. 40, no. 15, AMER CHEMICAL SOC, July 2001, pp. 3774–80. Wos, doi:10.1021/ic010181l. Full Text

Franz, K. J., et al. “Pentacoordinate cobalt(III) thiolate and nitrosyl tropocoronand compounds.” Inorganic Chemistry, vol. 40, no. 15, July 2001, pp. 3774–80. Epmc, doi:10.1021/ic010181l. Full Text

Franz, K. J., et al. “Aminotroponiminates as ligands for potential metal-based nitric oxide sensors.” Inorganic Chemistry, vol. 39, no. 18, Sept. 2000, pp. 4081–92. Epmc, doi:10.1021/ic000344q. Full Text

Franz, K. J., and S. J. Lippard. “Nitrosyl transfer from manganese to iron in tropocoronand complexes.” Inorganic Chemistry, vol. 39, no. 16, Aug. 2000, pp. 3722–23. Epmc, doi:10.1021/ic000360n. Full Text

Franz, K. J., et al. “Metal-based NO sensing by selective ligand dissociation.” Angewandte Chemie  International Edition, vol. 39, no. 12, 2000, pp. 2120–22. Scival, doi:10.1002/1521-3773(20000616)39:12<2120::AID-ANIE2120>3.0.CO;2-M. Full Text

Franz, K. J., and S. J. Lippard. “NO disproportionation reactivity of Fe tropocoronand complexes.” Journal of the American Chemical Society, vol. 121, no. 45, Nov. 1999, pp. 10504–12. Scopus, doi:10.1021/ja991664f. Full Text

Franz, K. J., et al. “Disproportionation of nitric oxide promoted by a Mn tropocoronand.” Chemtracts, vol. 12, no. 2, Feb. 1999, pp. 135–40.

Loehlin, J. H., et al. “Supramolecular Alcohol-Amine Crystals and Their Hydrogen-Bond Patterns.” Acta Crystallographica Section B: Structural Science, vol. 54, no. 5, Oct. 1998, pp. 695–704. Scopus, doi:10.1107/S0108768198003231. Full Text

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