Faculty Profiles

Katherine J. Franz
Katherine J. Franz
Chair of the Department of Chemistry
Office: 
2103 French Science Center, 124 Science Drive, Durham, NC 27708
Phone: 
(919) 660-1541
katherine.franz@duke.edu
Franz Research Group
Research Interests: 

Research in the Franz group is involved in elucidating the structural and functional consequences of metal ion coordination in biological systems. We are particularly interested in understanding the coordination chemistry utilized by biology to manage essential yet toxic species like copper and iron. Understanding these principles further guides our development of new chemical tools to manipulate biological metal ion location, speciation, and reactivity for potential therapeutic benefit. We use a combination of synthesis, spectroscopy, and biochemistry in our work. Please visit our group website to learn more about our research.

Overview

Education:

Ph.D., Massachusetts Institute of Technology 2000

B.A., Wellesley College 1995

Research Areas:
Biomolecular Structure and Function, Inorganic

Rubino, Jeffrey T., et al. “Methionine motifs of copper transport proteins provide general and flexible thioether-only binding sites for Cu(I) and Ag(I).” Journal of Biological Inorganic Chemistry : Jbic : A Publication of the Society of Biological Inorganic Chemistry, vol. 15, no. 7, Sept. 2010, pp. 1033–49. Epmc, doi:10.1007/s00775-010-0663-9. Full Text

Ciesienski, Katie L., et al. “Toward the detection of cellular copper(II) by a light-activated fluorescence increase.” Inorganic Chemistry, vol. 49, no. 15, Aug. 2010, pp. 6808–10. Epmc, doi:10.1021/ic1004165. Full Text Open Access Copy

Ciesienski, K. L., et al. “A photo-caged platinum(II) complex that increases cytotoxicity upon light activation.” European Journal of Inorganic Chemistry, no. 15, May 2010, pp. 2224–28. Scopus, doi:10.1002/ejic.201000098. Full Text

Franz, Katherine J., and Chuan He. “The highways and byways of bioinorganic chemistry.” Current Opinion in Chemical Biology, vol. 14, no. 2, Apr. 2010, pp. 208–10. Epmc, doi:10.1016/j.cbpa.2010.02.011. Full Text

Folk, Drew S., and Katherine J. Franz. “A prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation.” Journal of the American Chemical Society, vol. 132, no. 14, Apr. 2010, pp. 4994–95. Epmc, doi:10.1021/ja100943r. Full Text Open Access Copy

Perez, Lissette R., and Katherine J. Franz. “Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.” Dalton Transactions (Cambridge, England : 2003), vol. 39, no. 9, Mar. 2010, pp. 2177–87. Epmc, doi:10.1039/b919237a. Full Text Open Access Copy

Tangen, Espen, et al. “Electronic structure of a paramagnetic {MNO}6 complex: MnNO 5,5-tropocoronand.” Inorganic Chemistry, vol. 49, no. 6, Mar. 2010, pp. 2701–05. Epmc, doi:10.1021/ic901860x. Full Text

Hyman, Lynne M., et al. “Toward the development of prochelators as fluorescent probes of copper-mediated oxidative stress.” Dalton Transactions (Cambridge, England : 2003), no. 2, Jan. 2010, pp. 568–76. Epmc, doi:10.1039/b914568k. Full Text

Dickens, Marina G., and Katherine J. Franz. “A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.” Chembiochem : A European Journal of Chemical Biology, vol. 11, no. 1, Jan. 2010, pp. 59–62. Epmc, doi:10.1002/cbic.200900597. Full Text

Crider, Sarah E., et al. “Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1.” Metallomics : Integrated Biometal Science, vol. 2, no. 1, Jan. 2010, pp. 74–83. Epmc, doi:10.1039/b916899k. Full Text Open Access Copy

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