Faculty Profiles

Katherine J. Franz
Chair of the Department of Chemistry
2103 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1541



Ph.D., Massachusetts Institute of Technology 2000

B.A., Wellesley College 1995

Research Areas:
Biomolecular Structure and Function, Inorganic

Jansová, Hana, et al. “Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products.Toxicology, vol. 350–352, Mar. 2016, pp. 15–24. Epmc, doi:10.1016/j.tox.2016.03.004. Full Text

Franks, Andrew T., et al. “A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stress.Bioorganic & Medicinal Chemistry Letters, vol. 25, no. 21, Nov. 2015, pp. 4843–47. Epmc, doi:10.1016/j.bmcl.2015.06.048. Full Text

Pushie, M. Jake, et al. “Model Peptide Studies Reveal a Mixed Histidine-Methionine Cu(I) Binding Site at the N-Terminus of Human Copper Transporter 1.Inorganic Chemistry, vol. 54, no. 17, Sept. 2015, pp. 8544–51. Epmc, doi:10.1021/acs.inorgchem.5b01162. Full Text

Alies, Bruno, et al. “A prochelator peptide designed to use heterometallic cooperativity to enhance metal ion affinity.Chemical Science, vol. 6, no. 6, June 2015, pp. 3606–10. Epmc, doi:10.1039/c5sc00602c. Full Text

Crumbliss, Alvin L., et al. “Preface. Biometals 2014--Proceedings of the 9th International Symposium Biometals 2014 at Duke University, Durham, NC, USA.Biometals : An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine, vol. 28, no. 3, June 2015, p. 431. Epmc, doi:10.1007/s10534-015-9854-8. Full Text

Helsel, Marian E., and Katherine J. Franz. “Pharmacological activity of metal binding agents that alter copper bioavailability.Dalton Transactions (Cambridge, England : 2003), vol. 44, no. 19, May 2015, pp. 8760–70. Epmc, doi:10.1039/c5dt00634a. Full Text

Bureš, Jan, et al. “LC-UV/MS methods for the analysis of prochelator-boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH).Journal of Pharmaceutical and Biomedical Analysis, vol. 105, Feb. 2015, pp. 55–63. Epmc, doi:10.1016/j.jpba.2014.11.044. Full Text

Safi, Rachid, et al. “Copper signaling axis as a target for prostate cancer therapeutics.Cancer Res, vol. 74, no. 20, Oct. 2014, pp. 5819–31. Pubmed, doi:10.1158/0008-5472.CAN-13-3527. Full Text Open Access Copy

Franks, Andrew T., and Katherine J. Franz. “A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting.Chemical Communications (Cambridge, England), vol. 50, no. 77, Oct. 2014, pp. 11317–20. Epmc, doi:10.1039/c4cc05076b. Full Text

Jansová, Hana, et al. “Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury.Free Radical Biology & Medicine, vol. 74, Sept. 2014, pp. 210–21. Epmc, doi:10.1016/j.freeradbiomed.2014.06.019. Full Text


Liu, L. L., and K. J. Franz. “Characterization of metal binding sites in a synthetic phosphorylated alpha-synuclein peptide fragment.Abstracts of Papers of the American Chemical Society, vol. 229, AMER CHEMICAL SOC, 2005, pp. U1080–81.

Franz, Katherine J., et al. “Development of lanthanide-binding peptides as natively expressed protein probes.” Journal of Inorganic Biochemistry, vol. 96, no. 1, Elsevier BV, 2003, pp. 131–131. Crossref, doi:10.1016/s0162-0134(03)80614-1. Full Text