Faculty Profiles

Jiyong Hong
Professor of Chemistry
3220 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1545
(919) 660-1605



Ph.D., The Scripps Research Institute 2001

M.S., Seoul National University 1995

B.S., Seoul National University 1993

Research Areas:
Synthesis, Biological, Organic

Lee, H, Sylvester, K, Derbyshire, ER, and Hong, J. "Synthesis and Analysis of Natural-Product-Like Macrocycles by Tandem Oxidation/Oxa-Conjugate Addition Reactions." Chemistry (Weinheim an Der Bergstrasse, Germany) 25.26 (May 2019): 6500-6504. Full Text

Lee, M, Zhao, J, Kwak, S-H, Cho, J, Lee, M, Gillespie, RA, Kwon, D-Y, Lee, H, Park, H-J, Wu, Q, Zhou, P, and Hong, J. "Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay." Acs Infectious Diseases 5.4 (April 2019): 641-651. Full Text

Eubanks, AL, Perkins, MM, Sylvester, K, Ganley, JG, Posfai, D, Sanschargrin, PC, Hong, J, Sliz, P, and Derbyshire, ER. "In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors." Chemmedchem 13.23 (December 2018): 2479-2483. Full Text

Kwon, D-Y, Lee, K, Park, H, Kim, MJ, and Hong, J. "Synthetic efforts towards the stereoselective synthesis of NF00659B1." Bioorganic & Medicinal Chemistry Letters 28.16 (September 2018): 2746-2750. Full Text

Siska, PJ, Beckermann, KE, Mason, FM, Andrejeva, G, Greenplate, AR, Sendor, AB, Chiang, Y-CJ, Corona, AL, Gemta, LF, Vincent, BG, Wang, RC, Kim, B, Hong, J, Chen, C-L, Bullock, TN, Irish, JM, Rathmell, WK, and Rathmell, JC. "Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma." Jci Insight 2.12 (June 15, 2017). Full Text

Kim, B, Ratnayake, R, Lee, H, Shi, G, Zeller, SL, Li, C, Luesch, H, and Hong, J. "Synthesis and biological evaluation of largazole zinc-binding group analogs." Bioorganic & medicinal chemistry 25.12 (June 2017): 3077-3086. Full Text

Lanier, ML, Park, H, Mukherjee, P, Timmerman, JC, Ribeiro, AA, Widenhoefer, RA, and Hong, J. "Formal Synthesis of (+)-Laurencin by Gold(I)-Catalyzed Intramolecular Dehydrative Alkoxylation." Chemistry (Weinheim an der Bergstrasse, Germany) 23.30 (May 2017): 7180-7184. Full Text

Siska, PJ, Kim, B, Ji, X, Hoeksema, MD, Massion, PP, Beckermann, KE, Wu, J, Chi, J-T, Hong, J, and Rathmell, JC. "Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes." Journal of Immunological Methods 438 (November 2016): 51-58. Full Text

Lee, K, Lanier, ML, Kwak, J-H, Kim, H, and Hong, J. "Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A." Natural product reports 33.12 (November 2016): 1393-1424. (Review) Full Text

Geer Wallace, MA, Kwon, D-Y, Weitzel, DH, Lee, C-T, Stephenson, TN, Chi, J-T, Mook, RA, Dewhirst, MW, Hong, J, and Fitzgerald, MC. "Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements." Journal of Proteome Research 15.8 (August 2016): 2688-2696. Full Text


Toone, EJ. Preface. December 1, 2011.

Garbaccio, RM, Johnson, DS, Hong, J, and Disney, MD. "Preface." November 2015. 4714-null. Full Text

Lee, H, and Hong, J. "Design and synthesis of a natural product-like macrocycle library containing tetrahydropyran moieties." 256th National Meeting and Exposition of the American-Chemical-Society (ACS) - Nanoscience, Nanotechnology and Beyond. August 19, 2018 - August 23, 2018. Boston, MA.: AMER CHEMICAL SOC, August 19, 2018.

Park, H, Lanier, M, Mukherjee, P, Ribeiro, A, Widenhoefer, R, and Hong, J. "Exploration of gold(I)-catalyzed alkoxylation for formal synthesis of (+)-laurencin." 253rd National Meeting of the American-Chemical-Society (ACS) on Advanced Materials, Technologies, Systems, and Processes. April 2, 2017 - April 6, 2017. San Francisco, CA.: AMER CHEMICAL SOC, April 2, 2017.

Lee, M, Zhao, J, Cho, J, Kwon, D-Y, Zhou, P, and Hong, J. "Synthesis and biological evaluation of sulfonyl piperazine derivatives for LpxH inhibition." 253rd National Meeting of the American-Chemical-Society (ACS) on Advanced Materials, Technologies, Systems, and Processes. April 2, 2017 - April 6, 2017. San Francisco, CA.: AMER CHEMICAL SOC, April 2, 2017.

Kwon, D-Y, Park, K, Weitzel, D, Lee, SH, Stephenson, T, Lee, C-T, Chi, J-T, Mook, R, Dewhirst, M, Lee, YM, and Hong, J. "Design, synthesis, and biological evaluation of manassantin analogues for HIF-1 alpha inhibition.": AMER CHEMICAL SOC, March 22, 2015.

Chung, BC, Zhao, J, Gillespie, R, Kwon, DY, Guan, Z, Hong, J, Zhou, P, and Lee, S-Y. "Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis.": Elsevier BV, January 2014. Full Text

Lee, K, Kim, H, and Hong, J. "Stereoselective formal synthesis of leucascandrolide A." August 28, 2011.

Harrington, JM, Park, H, Ying, Y, Hong, J, and Crumbliss, AL. "Thermodynamic characterization of iron(III) and zinc binding by Brasilibactin A." August 16, 2009.

Ying, Y, Kim, H, Taori, K, Luesch, H, and Hong, J. "ORGN 523-Total synthesis of largazole." August 17, 2008.