Faculty Profiles

Jiyong Hong
Professor of Chemistry
Office: 
3220 French Science Center, 124 Science Drive, Durham, NC 27708
Phone: 
(919) 660-1545
Fax: 
(919) 660-1605

Overview

Education:

Ph.D., The Scripps Research Institute 2001

M.S., Seoul National University 1995

B.S., Seoul National University 1993

Research Areas:
Synthesis, Biological, Organic

Lee, Hyunji, et al. “Synthesis and Analysis of Natural-Product-Like Macrocycles by Tandem Oxidation/Oxa-Conjugate Addition Reactions..” Chemistry (Weinheim an Der Bergstrasse, Germany), vol. 25, no. 26, May 2019, pp. 6500–04. Epmc, doi:10.1002/chem.201900620. Full Text

Lee, Minhee, et al. “Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay..” Acs Infectious Diseases, vol. 5, no. 4, Apr. 2019, pp. 641–51. Epmc, doi:10.1021/acsinfecdis.8b00364. Full Text

Eubanks, Amber L., et al. “In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors..” Chemmedchem, vol. 13, no. 23, Dec. 2018, pp. 2479–83. Epmc, doi:10.1002/cmdc.201800625. Full Text

Kwon, Do-Yeon, et al. “Synthetic efforts towards the stereoselective synthesis of NF00659B1..” Bioorganic & Medicinal Chemistry Letters, vol. 28, no. 16, Sept. 2018, pp. 2746–50. Epmc, doi:10.1016/j.bmcl.2018.02.038. Full Text

Siska, Peter J., et al. “Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma..” Jci Insight, vol. 2, no. 12, June 2017. Epmc, doi:10.1172/jci.insight.93411. Full Text

Kim, Bumki, et al. “Synthesis and biological evaluation of largazole zinc-binding group analogs..” Bioorganic & Medicinal Chemistry, vol. 25, no. 12, June 2017, pp. 3077–86. Epmc, doi:10.1016/j.bmc.2017.03.071. Full Text

Lanier, Megan L., et al. “Formal Synthesis of (+)-Laurencin by Gold(I)-Catalyzed Intramolecular Dehydrative Alkoxylation..” Chemistry (Weinheim an Der Bergstrasse, Germany), vol. 23, no. 30, May 2017, pp. 7180–84. Epmc, doi:10.1002/chem.201700499. Full Text

Siska, Peter J., et al. “Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes..” J Immunol Methods, vol. 438, Nov. 2016, pp. 51–58. Pubmed, doi:10.1016/j.jim.2016.08.013. Full Text

Lee, Kiyoun, et al. “Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A..” Natural Product Reports, vol. 33, no. 12, Nov. 2016, pp. 1393–424. Epmc, doi:10.1039/c6np00073h. Full Text

Geer Wallace, M. Ariel, et al. “Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements..” J Proteome Res, vol. 15, no. 8, Aug. 2016, pp. 2688–96. Pubmed, doi:10.1021/acs.jproteome.6b00237. Full Text

Pages

Toone, E. J. Preface. Vol. 78 1, 2011.

Garbaccio, Robert M., et al. Preface.. Vol. 25, 2015. Epmc, doi:10.1016/j.bmcl.2015.08.083. Full Text

Lee, Hyunji, and Jiyong Hong. “Design and synthesis of a natural product-like macrocycle library containing tetrahydropyran moieties.” Abstracts of Papers of the American Chemical Society, vol. 256, AMER CHEMICAL SOC, 2018.

Park, Hyeri, et al. “Exploration of gold(I)-catalyzed alkoxylation for formal synthesis of (+)-laurencin.” Abstracts of Papers of the American Chemical Society, vol. 253, AMER CHEMICAL SOC, 2017.

Lee, Minhee, et al. “Synthesis and biological evaluation of sulfonyl piperazine derivatives for LpxH inhibition.” Abstracts of Papers of the American Chemical Society, vol. 253, AMER CHEMICAL SOC, 2017.

Kwon, Do-Yeon, et al. “Design, synthesis, and biological evaluation of manassantin analogues for HIF-1 alpha inhibition.” Abstracts of Papers of the American Chemical Society, vol. 249, AMER CHEMICAL SOC, 2015.

Lanier, Megan L., et al. “Stereoselective synthesis of alpha,alpha '-trans-oxepanes through an organocatalytic oxa-conjugate addition reaction.” Abstracts of Papers of the American Chemical Society, vol. 247, AMER CHEMICAL SOC, 2014.

Chung, Ben C., et al. “Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis.” Biophysical Journal, vol. 106, no. 2, Elsevier BV, 2014, pp. 14a-14a. Crossref, doi:10.1016/j.bpj.2013.11.131. Full Text

Lee, Kiyoun, et al. “Stereoselective formal synthesis of leucascandrolide A.” Abstracts of Papers of the American Chemical Society, vol. 242, AMER CHEMICAL SOC, 2011.

Ying, Yongcheng, et al. “Efficient and stereoselective synthesis of 2,6-disubstituted piperidines through an organocatalytic aza-Michael reaction promoted by the gem-disubstituent effect.” Abstracts of Papers of the American Chemical Society, vol. 239, AMER CHEMICAL SOC, 2010.

Harrington, James M., et al. “Thermodynamic characterization of iron(III) and zinc binding by Brasilibactin A.” Abstracts of Papers of the American Chemical Society, vol. 238, AMER CHEMICAL SOC, 2009.

Ying, Yongcheng, et al. “ORGN 523-Total synthesis of largazole.” Abstracts of Papers of the American Chemical Society, vol. 236, AMER CHEMICAL SOC, 2008.