Faculty Profiles

Jiyong Hong
Professor of Chemistry
3220 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1545
(919) 660-1605



Ph.D., The Scripps Research Institute 2001

M.S., Seoul National University (South Korea) 1995

B.S., Seoul National University (South Korea) 1993

Research Areas:
Synthesis, Biological, Organic

Yu, Mingming, et al. “Largazole pharmacokinetics in rats by LC-MS/MS.Marine Drugs, vol. 12, no. 3, Mar. 2014, pp. 1623–40. Epmc, doi:10.3390/md12031623. Full Text

Strickland, Erin C., et al. “False-positive rate determination of protein target discovery using a covalent modification- and mass spectrometry-based proteomics platform.Journal of the American Society for Mass Spectrometry, vol. 25, no. 1, Jan. 2014, pp. 132–40. Epmc, doi:10.1007/s13361-013-0754-2. Full Text

Chung, Ben C., et al. “Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis.Science, vol. 341, no. 6149, Aug. 2013, pp. 1012–16. Pubmed, doi:10.1126/science.1236501. Full Text

Law, M. E., et al. “Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms.Oncogene, vol. 32, no. 10, Mar. 2013, pp. 1316–29. Epmc, doi:10.1038/onc.2012.138. Full Text

Chung, B. C., et al. “Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis.” Science, vol. 341, no. 6149, 2013, pp. 1012–16. Scival, doi:10.1126/science.1240985. Full Text

Kaoud, Tamer S., et al. “Manipulating JNK signaling with (--)-zuonin A.Acs Chemical Biology, vol. 7, no. 11, Nov. 2012, pp. 1873–83. Epmc, doi:10.1021/cb300261e. Full Text

Kaoud, Tamer S., et al. “From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules.Acs Medicinal Chemistry Letters, vol. 3, no. 9, Aug. 2012, pp. 721–25. Epmc, doi:10.1021/ml300129b. Full Text

Lee, Kiyoun, et al. “N-Heterocyclic carbene catalyzed oxidative macrolactonization: total synthesis of (+)-dactylolide.Angewandte Chemie (International Ed. in English), vol. 51, no. 23, June 2012, pp. 5735–38. Epmc, doi:10.1002/anie.201201653. Full Text

Hong, Jiyong, and Hendrik Luesch. “Largazole: from discovery to broad-spectrum therapy.Natural Product Reports, vol. 29, no. 4, Apr. 2012, pp. 449–56. Epmc, doi:10.1039/c2np00066k. Full Text

Lee, K., et al. “Stereoselective synthesis of tetrahydropyrans through tandem and organocatalytic oxa-Michael reactions: Synthesis of the tetrahydropyran cores of ent-(+)-sorangicin A.” European Journal of Organic Chemistry, no. 5, Feb. 2012, pp. 1025–32. Scopus, doi:10.1002/ejoc.201101549. Full Text