Faculty Profiles

Jiyong Hong
Professor of Chemistry
3220 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1545
(919) 660-1605



Ph.D., The Scripps Research Institute 2001

M.S., Seoul National University (South Korea) 1995

B.S., Seoul National University (South Korea) 1993

Research Areas:
Synthesis, Biological, Organic

Ying, Yongcheng, et al. “Synthesis and activity of largazole analogues with linker and macrocycle modification.Organic Letters, vol. 10, no. 18, Sept. 2008, pp. 4021–24. Epmc, doi:10.1021/ol801532s. Full Text

Ying, Yongcheng, et al. “Total synthesis and molecular target of largazole, a histone deacetylase inhibitor.Journal of the American Chemical Society, vol. 130, no. 26, July 2008, pp. 8455–59. Epmc, doi:10.1021/ja8013727. Full Text

Lee, Hyunjoo, et al. “A general strategy for construction of both 2,6-cis- and 2,6-trans-disubstituted tetrahydropyrans: substrate-controlled asymmetric total synthesis of (+)-scanlonenyne.Angewandte Chemie (International Ed. in English), vol. 47, no. 22, Jan. 2008, pp. 4200–03. Epmc, doi:10.1002/anie.200705663. Full Text

Ying, Y., and J. Hong. “Synthesis of brasilibactin A and confirmation of absolute configuration of β-hydroxy acid fragment.” Tetrahedron Letters, vol. 48, no. 46, Nov. 2007, pp. 8104–07. Scopus, doi:10.1016/j.tetlet.2007.09.112. Full Text

Lee, Jongkook, et al. “A small-molecule antagonist of the hedgehog signaling pathway.Chembiochem : A European Journal of Chemical Biology, vol. 8, no. 16, Nov. 2007, pp. 1916–19. Epmc, doi:10.1002/cbic.200700403. Full Text

Hong, Jiyong, et al. “Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiation.Acs Chemical Biology, vol. 2, no. 3, Mar. 2007, pp. 171–75. Epmc, doi:10.1021/cb600435t. Full Text

Collins, Cynthia S., et al. “A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase.Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 10, Mar. 2006, pp. 3775–80. Epmc, doi:10.1073/pnas.0600040103. Full Text

Collins, C., et al. “A genetic siRNA screen for modulators of tumor cell motility identifies MAP4K4 as a pro-migratory kinase.” Proceedings of the National Academy of Sciences Usa, vol. 103, no. 10, 2006, pp. 3775–80.

Lee, Jongkook, and Jiyong Hong. “First synthesis and structural elucidation of (-)-presphaerene.The Journal of Organic Chemistry, vol. 69, no. 19, Sept. 2004, pp. 6433–40. Epmc, doi:10.1021/jo049351c. Full Text