Faculty Profiles

Jiyong Hong
Professor of Chemistry
3220 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1545
(919) 660-1605



Ph.D., The Scripps Research Institute 2001

M.S., Seoul National University 1995

B.S., Seoul National University 1993

Research Areas:
Synthesis, Biological, Organic

Lee, Kiyoun, et al. “Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A..” Natural Product Reports, vol. 33, no. 12, Nov. 2016, pp. 1393–424. Epmc, doi:10.1039/c6np00073h. Full Text

Geer Wallace, M. Ariel, et al. “Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements..” J Proteome Res, vol. 15, no. 8, Aug. 2016, pp. 2688–96. Pubmed, doi:10.1021/acs.jproteome.6b00237. Full Text

Chung, Ben C., et al. “Structural insights into inhibition of lipid I production in bacterial cell wall synthesis..” Nature, vol. 533, no. 7604, May 2016, pp. 557–60. Pubmed, doi:10.1038/nature17636. Full Text

Kwon, Do-Yeon, et al. “Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition..” J Med Chem, vol. 58, no. 19, Oct. 2015, pp. 7659–71. Pubmed, doi:10.1021/acs.jmedchem.5b01220. Full Text

Baker, Joseph B., et al. “Total Synthesis of Clavosolide A via Tandem Allylic Oxidation/Oxa-Conjugate Addition Reaction..” Tetrahedron Letters, vol. 56, no. 23, June 2015, pp. 3120–22. Epmc, doi:10.1016/j.tetlet.2014.11.135. Full Text

Lim, Wonchung, et al. “Subglutinol A, an immunosuppressive α-pyrone diterpenoid from Fusarium subglutinans, acts as an estrogen receptor antagonist..” Biochemical and Biophysical Research Communications, vol. 461, no. 3, June 2015, pp. 507–12. Epmc, doi:10.1016/j.bbrc.2015.04.053. Full Text

Kim, Bumki, and Jiyong Hong. “An overview of naturally occurring histone deacetylase inhibitors..” Current Topics in Medicinal Chemistry, vol. 14, no. 24, Jan. 2015, pp. 2759–82. Epmc, doi:10.2174/1568026615666141208105614. Full Text

Hong, Jiyong. “Natural product synthesis at the interface of chemistry and biology..” Chemistry (Weinheim an Der Bergstrasse, Germany), vol. 20, no. 33, Aug. 2014, pp. 10204–12. Epmc, doi:10.1002/chem.201402804. Full Text

Kim, Bumki, et al. “Evaluation of class I HDAC isoform selectivity of largazole analogues..” Bioorganic & Medicinal Chemistry Letters, vol. 24, no. 16, Aug. 2014, pp. 3728–31. Epmc, doi:10.1016/j.bmcl.2014.07.006. Full Text

Salvador, Lilibeth A., et al. “Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties..” Acs Medicinal Chemistry Letters, vol. 5, no. 8, Aug. 2014, pp. 905–10. Epmc, doi:10.1021/ml500170r. Full Text