Faculty Profiles

Jennifer Roizen
Jennifer Roizen
Assistant Professor of Chemistry
Office: 
1104 French Science Center, Durham, NC 27701
Phone: 
(919) 660-9438
Fax: 
(919) 660-1605
jennifer.roizen@duke.edu
Roizen Research Group
Research Interests: 

Inspired by small molecule natural products, the Roizen laboratories will initiate research to access improved antibiotics, and selective ion channel inhibitors, with implications for the study and treatment of cancer, heart disease, and neurological disorders. This program will begin with the development of novel reaction methods, and where appropriate these methodologies will be advanced through mechanistic investigations. New reactions will be designed to streamline access to challenging natural products, such as the guaianolide sesquiterpenes. Access to these small molecules will enable us to collaborate with colleagues to probe the biological activity of these molecular architectures.

Overview

Education:

Postdoctoral Fellow, Chemistry, Stanford University 2010 - 2013

Ph.D., California Institute of Technology 2009

B.A., Williams College 2003

Research Areas:
Synthesis, Inorganic, Organic

Ayer, Suraj K., and J. L. Roizen. “Sulfamate Esters Guide C(3)-Selective Xanthylation of Alkanes..” The Journal of Organic Chemistry, vol. 84, no. 6, Mar. 2019, pp. 3508–23. Epmc, doi:10.1021/acs.joc.9b00105. Full Text

Craig, Robert A., et al. “Correction: Enantioselective, convergent synthesis of the ineleganolide core by a tandem annulation cascade..” Chemical Science, vol. 10, no. 4, Jan. 2019, pp. 1254–55. Epmc, doi:10.1039/c8sc90236d. Full Text

Shehata, M. F., et al. “Efficient synthesis of unsymmetrical sulfamides from sulfamic acid salts by activation with triphenylphosphine ditriflate.” Tetrahedron, Jan. 2019. Scopus, doi:10.1016/j.tet.2019.02.063. Full Text

Mack, J. B. C., et al. “Rhodium-Catalyzed C-H Amination: A Case Study of Selectivity in C-H Functionalization Reactions.” Journal of Chemical Education, vol. 95, no. 12, Dec. 2018, pp. 2243–48. Scopus, doi:10.1021/acs.jchemed.7b00697. Full Text

Blackburn, J. Miles, and Jennifer L. Roizen. “Easy access to elusive radical reactions..” Science (New York, N.Y.), vol. 362, no. 6411, Oct. 2018, pp. 157–58. Epmc, doi:10.1126/science.aav0574. Full Text

Shehata, Mina F., et al. “Iron(MCP) Complexes Catalyze Aziridination with Olefins As Limiting Reagents..” The Journal of Organic Chemistry, vol. 83, no. 9, May 2018, pp. 5072–81. Epmc, doi:10.1021/acs.joc.8b00402. Full Text

Craig, Robert A., et al. “Development of a Unified Enantioselective, Convergent Synthetic Approach Toward the Furanobutenolide-Derived Polycyclic Norcembranoid Diterpenes: Asymmetric Formation of the Polycyclic Norditerpenoid Carbocyclic Core by Tandem Annulation Cascade..” The Journal of Organic Chemistry, vol. 83, no. 7, Apr. 2018, pp. 3467–85. Epmc, doi:10.1021/acs.joc.7b02825. Full Text

Short, Melanie A., et al. “Sulfamate Esters Guide Selective Radical-Mediated Chlorination of Aliphatic C−H Bonds.” Angewandte Chemie, vol. 130, no. 1, Wiley, Jan. 2018, pp. 302–05. Crossref, doi:10.1002/ange.201710322. Full Text

Short, Melanie A., et al. “Sulfamate Esters Guide Selective Radical-Mediated Chlorination of Aliphatic C-H Bonds..” Angewandte Chemie (International Ed. in English), vol. 57, no. 1, Jan. 2018, pp. 296–99. Epmc, doi:10.1002/anie.201710322. Full Text

Roizen, Jennifer L., et al. “Model Studies To Access the [6,7,5,5]-Core of Ineleganolide Using Tandem Translactonization-Cope or Cyclopropanation-Cope Rearrangements as Key Steps..” The Journal of Organic Chemistry, vol. 82, no. 24, Dec. 2017, pp. 13051–67. Epmc, doi:10.1021/acs.joc.7b02030. Full Text

Pages

Shehata, Mina, et al. “Iron-mediated aziridination.” Abstracts of Papers of the American Chemical Society, vol. 254, AMER CHEMICAL SOC, 2017.

Roizen, Jennifer, et al. “Enantioselective, convergent synthesis of the ineleganolide core by a tandem annulation cascade.” Abstracts of Papers of the American Chemical Society, vol. 253, AMER CHEMICAL SOC, 2017.

Blackburn, Jeffrey, et al. “Selective and serial cross-coupling reactions of (hetero)aromatic substrates with multiple electrophilic bonds.” Abstracts of Papers of the American Chemical Society, vol. 252, AMER CHEMICAL SOC, 2016.

Laulhe, Sebastien, and Jennifer Roizen. “Selective cross-coupling of 2,6-dihalopyridines with alkylboronic esters.” Abstracts of Papers of the American Chemical Society, vol. 250, AMER CHEMICAL SOC, 2015.

Cox, Charles T., et al. “Bridging the gap between research and teaching: A C-H insertion project.” Abstracts of Papers of the American Chemical Society, vol. 246, AMER CHEMICAL SOC, 2013.