Faculty Profiles

Jennifer Roizen
Jennifer Roizen
Assistant Professor of Chemistry
Office: 
1104 French Science Center, Durham, NC 27701
Phone: 
(919) 660-9438
Fax: 
(919) 660-1605
jennifer.roizen@duke.edu
Roizen Research Group
Research Interests: 

Inspired by small molecule natural products, the Roizen laboratories will initiate research to access improved antibiotics, and selective ion channel inhibitors, with implications for the study and treatment of cancer, heart disease, and neurological disorders. This program will begin with the development of novel reaction methods, and where appropriate these methodologies will be advanced through mechanistic investigations. New reactions will be designed to streamline access to challenging natural products, such as the guaianolide sesquiterpenes. Access to these small molecules will enable us to collaborate with colleagues to probe the biological activity of these molecular architectures.

Overview

Education:

Postdoctoral Fellow, Chemistry, Stanford University 2010 - 2013

Ph.D., California Institute of Technology 2009

B.A., Williams College 2003

Research Areas:
Synthesis, Inorganic, Organic

Simons, R. Thomas, et al. “Photochemically Mediated Nickel-Catalyzed Synthesis of N-(Hetero)aryl Sulfamides.” The Journal of Organic Chemistry, vol. 85, no. 10, May 2020, pp. 6380–91. Epmc, doi:10.1021/acs.joc.0c00139. Full Text

Short, Melanie A., et al. “Modifying Positional Selectivity in C-H Functionalization Reactions with Nitrogen-Centered Radicals: Generalizable Approaches to 1,6-Hydrogen-Atom Transfer Processes.” Synlett, vol. 31, no. 2, GEORG THIEME VERLAG KG, Jan. 2020, pp. 102–16. Wos, doi:10.1055/s-0039-1691501;ArtID:st-2019-p0583-sp. Full Text

Short, M. A., et al. “Modifying Positional Selectivity in C-H Functionalization Reactions with Nitrogen-Centered Radicals: Generalizable Approaches to 1,6-Hydrogen-Atom Transfer Processes.” Synlett, vol. 31, no. 2, Jan. 2020, pp. 102–16. Scopus, doi:10.1055/s-0039-1691501. Full Text

Short, M. A., et al. “Sulfamides direct radical-mediated chlorination of aliphatic C-H bonds.” Chemical Science, vol. 11, no. 1, Jan. 2020, pp. 217–23. Scopus, doi:10.1039/c9sc03428e. Full Text

Blackburn, J. Miles, et al. “Photochemically-Mediated, Nickel-Catalyzed Synthesis of N-(Hetero)aryl Sulfamate Esters.” Organic Letters, vol. 21, no. 17, Sept. 2019, pp. 7049–54. Epmc, doi:10.1021/acs.orglett.9b02621. Full Text

Kanegusuku, Anastasia L. G., et al. “Sulfamyl Radicals Direct Photoredox-Mediated Giese Reactions at Unactivated C(3)-H Bonds.” Organic Letters, vol. 21, no. 15, Aug. 2019, pp. 6089–95. Epmc, doi:10.1021/acs.orglett.9b02234. Full Text

Blackburn, J. M., and J. L. Roizen. “Catalytic Strategies to Convert 2-Halopyridines to 2-Alkylpyridines.” Asian Journal of Organic Chemistry, vol. 8, no. 7, July 2019, pp. 920–30. Scopus, doi:10.1002/ajoc.201900163. Full Text

Shehata, M. F., et al. “Efficient synthesis of unsymmetrical sulfamides from sulfamic acid salts by activation with triphenylphosphine ditriflate.” Tetrahedron, vol. 75, no. 24, June 2019, pp. 3186–94. Scopus, doi:10.1016/j.tet.2019.02.063. Full Text

Craig, Robert A., et al. “Unified Enantioselective, Convergent Synthetic Approach toward the Furanobutenolide-Derived Polycyclic Norcembranoid Diterpenes: Synthesis of a Series of Ineleganoloids by Oxidation-State Manipulation of the Carbocyclic Core.” The Journal of Organic Chemistry, vol. 84, no. 12, June 2019, pp. 7722–46. Epmc, doi:10.1021/acs.joc.9b00635. Full Text

Short, Melanie A., et al. “A five-coordinate iron(III) porphyrin complex including a neutral axial pyridine N-oxide ligand.” Acta Crystallographica. Section C, Structural Chemistry, vol. 75, no. Pt 6, June 2019, pp. 717–22. Epmc, doi:10.1107/s2053229619005849. Full Text

Pages

Kanegusuku, Anastasia Gant, et al. “Sulfamate esters guide selective alkylation at traditionally non-reactive gamma-C(sp3)-H bonds.” Abstracts of Papers of the American Chemical Society, vol. 256, AMER CHEMICAL SOC, 2018.

Shehata, Mina, et al. “Iron-mediated aziridination.” Abstracts of Papers of the American Chemical Society, vol. 254, AMER CHEMICAL SOC, 2017.

Roizen, Jennifer, et al. “Enantioselective, convergent synthesis of the ineleganolide core by a tandem annulation cascade.” Abstracts of Papers of the American Chemical Society, vol. 253, AMER CHEMICAL SOC, 2017.

Blackburn, Jeffrey, et al. “Selective and serial cross-coupling reactions of (hetero)aromatic substrates with multiple electrophilic bonds.” Abstracts of Papers of the American Chemical Society, vol. 252, AMER CHEMICAL SOC, 2016.

Laulhe, Sebastien, and Jennifer Roizen. “Selective cross-coupling of 2,6-dihalopyridines with alkylboronic esters.” Abstracts of Papers of the American Chemical Society, vol. 250, AMER CHEMICAL SOC, 2015.

Cox, Charles T., et al. “Bridging the gap between research and teaching: A C-H insertion project.” Abstracts of Papers of the American Chemical Society, vol. 246, AMER CHEMICAL SOC, 2013.