Faculty Profiles

Hashim Al-Hashimi
Professor of Chemistry

Overview

Education:

Ph.D., Yale University 2000

Xu, Yu, et al. “Hoogsteen base pairs increase the susceptibility of double-stranded DNA to cytotoxic damage.J Biol Chem, vol. 295, no. 47, Nov. 2020, pp. 15933–47. Pubmed, doi:10.1074/jbc.RA120.014530. Full Text

Shi, Honglue, et al. “Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction.Nat Commun, vol. 11, no. 1, Nov. 2020, p. 5531. Pubmed, doi:10.1038/s41467-020-19371-y. Full Text

Afek, Ariel, et al. “DNA mismatches reveal conformational penalties in protein-DNA recognition.Nature, vol. 587, no. 7833, Nov. 2020, pp. 291–96. Pubmed, doi:10.1038/s41586-020-2843-2. Full Text

Rangadurai, Atul, et al. “Probing conformational transitions towards mutagenic Watson-Crick-like G·T mismatches using off-resonance sugar carbon R1ρ relaxation dispersion.J Biomol Nmr, vol. 74, no. 8–9, Sept. 2020, pp. 457–71. Pubmed, doi:10.1007/s10858-020-00337-7. Full Text

Rangadurai, Atul, et al. “Extending the Sensitivity of CEST NMR Spectroscopy to Micro-to-Millisecond Dynamics in Nucleic Acids Using High-Power Radio-Frequency Fields.Angew Chem Int Ed Engl, vol. 59, no. 28, July 2020, pp. 11262–66. Pubmed, doi:10.1002/anie.202000493. Full Text

Li, Pengfei, et al. “Environmental Effects on Guanine-Thymine Mispair Tautomerization Explored with Quantum Mechanical/Molecular Mechanical Free Energy Simulations.J Am Chem Soc, vol. 142, no. 25, June 2020, pp. 11183–91. Pubmed, doi:10.1021/jacs.0c03774. Full Text

Kladwang, Wipapat, et al. “Anomalous Reverse Transcription through Chemical Modifications in Polyadenosine Stretches.Biochemistry, vol. 59, no. 23, June 2020, pp. 2154–70. Pubmed, doi:10.1021/acs.biochem.0c00020. Full Text

Ganser, Laura R., et al. “Publisher Correction: High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble.Nat Struct Mol Biol, vol. 27, no. 6, June 2020, p. 604. Pubmed, doi:10.1038/s41594-020-0434-4. Full Text

Ganser, Laura R., et al. “Probing RNA Conformational Equilibria within the Functional Cellular Context.Cell Rep, vol. 30, no. 8, Feb. 2020, pp. 2472-2480.e4. Pubmed, doi:10.1016/j.celrep.2020.02.004. Full Text

Pages

Goh, Garrett B., et al. “Elucidating transient protonated GC(+) Hoogstein base pairs in canonical DNA duplexes.” Abstracts of Papers of the American Chemical Society, vol. 245, 2013.