Faculty Profiles

Hashim Al-Hashimi
Professor of Chemistry

Overview

Education:

Ph.D., Yale University 2000

Kladwang, Wipapat, et al. “Anomalous Reverse Transcription through Chemical Modifications in Polyadenosine Stretches.Biochemistry, vol. 59, no. 23, June 2020, pp. 2154–70. Pubmed, doi:10.1021/acs.biochem.0c00020. Full Text

Ganser, Laura R., et al. “Publisher Correction: High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble.Nat Struct Mol Biol, vol. 27, no. 6, June 2020, p. 604. Pubmed, doi:10.1038/s41594-020-0434-4. Full Text

Rangadurai, Atul, et al. “Extending the Sensitivity of CEST NMR Spectroscopy to Micro-to-Millisecond Dynamics in Nucleic Acids Using High-Power Radio-Frequency Fields.Angew Chem Int Ed Engl, Mar. 2020. Pubmed, doi:10.1002/anie.202000493. Full Text

Ganser, Laura R., et al. “Probing RNA Conformational Equilibria within the Functional Cellular Context.Cell Rep, vol. 30, no. 8, Feb. 2020, pp. 2472-2480.e4. Pubmed, doi:10.1016/j.celrep.2020.02.004. Full Text

Ganser, Laura R., et al. “Demonstration that Small Molecules can Bind and Stabilize Low-abundance Short-lived RNA Excited Conformational States.J Mol Biol, vol. 432, no. 4, Feb. 2020, pp. 1297–304. Pubmed, doi:10.1016/j.jmb.2019.12.009. Full Text

Orlovsky, Nicole I., et al. “Exposing Hidden High-Affinity RNA Conformational States.J Am Chem Soc, vol. 142, no. 2, Jan. 2020, pp. 907–21. Pubmed, doi:10.1021/jacs.9b10535. Full Text

Shi, Honglue, et al. “NMR Chemical Exchange Measurements Reveal That N6-Methyladenosine Slows RNA Annealing.J Am Chem Soc, vol. 141, no. 51, Dec. 2019, pp. 19988–93. Pubmed, doi:10.1021/jacs.9b10939. Full Text

Stelling, Allison L., et al. “Infrared Spectroscopic Observation of a G-C+ Hoogsteen Base Pair in the DNA:TATA-Box Binding Protein Complex Under Solution Conditions.Angew Chem Int Ed Engl, vol. 58, no. 35, Aug. 2019, pp. 12010–13. Pubmed, doi:10.1002/anie.201902693. Full Text

Ganser, Laura R., et al. “The roles of structural dynamics in the cellular functions of RNAs.Nat Rev Mol Cell Biol, vol. 20, no. 8, Aug. 2019, pp. 474–89. Pubmed, doi:10.1038/s41580-019-0136-0. Full Text

Pages

Goh, Garrett B., et al. “Elucidating transient protonated GC(+) Hoogstein base pairs in canonical DNA duplexes.” Abstracts of Papers of the American Chemical Society, vol. 245, 2013.