Faculty Profiles

Hashim Al-Hashimi
Professor of Chemistry

Overview

Education:

Ph.D., Yale University 2000

Rangadurai, Atul, et al. “Probing conformational transitions towards mutagenic Watson-Crick-like G·T mismatches using off-resonance sugar carbon R1ρ relaxation dispersion.J Biomol Nmr, vol. 74, no. 8–9, Sept. 2020, pp. 457–71. Pubmed, doi:10.1007/s10858-020-00337-7. Full Text

Rangadurai, Atul, et al. “Extending the Sensitivity of CEST NMR Spectroscopy to Micro-to-Millisecond Dynamics in Nucleic Acids Using High-Power Radio-Frequency Fields.Angew Chem Int Ed Engl, vol. 59, no. 28, July 2020, pp. 11262–66. Pubmed, doi:10.1002/anie.202000493. Full Text

Li, Pengfei, et al. “Environmental Effects on Guanine-Thymine Mispair Tautomerization Explored with Quantum Mechanical/Molecular Mechanical Free Energy Simulations.J Am Chem Soc, vol. 142, no. 25, June 2020, pp. 11183–91. Pubmed, doi:10.1021/jacs.0c03774. Full Text

Kladwang, Wipapat, et al. “Anomalous Reverse Transcription through Chemical Modifications in Polyadenosine Stretches.Biochemistry, vol. 59, no. 23, June 2020, pp. 2154–70. Pubmed, doi:10.1021/acs.biochem.0c00020. Full Text

Ganser, Laura R., et al. “Publisher Correction: High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble.Nat Struct Mol Biol, vol. 27, no. 6, June 2020, p. 604. Pubmed, doi:10.1038/s41594-020-0434-4. Full Text

Ganser, Laura R., et al. “Probing RNA Conformational Equilibria within the Functional Cellular Context.Cell Rep, vol. 30, no. 8, Feb. 2020, pp. 2472-2480.e4. Pubmed, doi:10.1016/j.celrep.2020.02.004. Full Text

Ganser, Laura R., et al. “Demonstration that Small Molecules can Bind and Stabilize Low-abundance Short-lived RNA Excited Conformational States.J Mol Biol, vol. 432, no. 4, Feb. 2020, pp. 1297–304. Pubmed, doi:10.1016/j.jmb.2019.12.009. Full Text

Orlovsky, Nicole I., et al. “Exposing Hidden High-Affinity RNA Conformational States.J Am Chem Soc, vol. 142, no. 2, Jan. 2020, pp. 907–21. Pubmed, doi:10.1021/jacs.9b10535. Full Text

Shi, Honglue, et al. “NMR Chemical Exchange Measurements Reveal That N6-Methyladenosine Slows RNA Annealing.J Am Chem Soc, vol. 141, no. 51, Dec. 2019, pp. 19988–93. Pubmed, doi:10.1021/jacs.9b10939. Full Text

Pages

Goh, Garrett B., et al. “Elucidating transient protonated GC(+) Hoogstein base pairs in canonical DNA duplexes.” Abstracts of Papers of the American Chemical Society, vol. 245, 2013.