Faculty Profiles

Hashim Al-Hashimi
James B. Duke Professor of Biochemistry

Overview

Education:

Ph.D., Yale University 2000

Stelling, AL, Xu, Y, Zhou, H, Choi, SH, Clay, MC, Merriman, DK, and Al-Hashimi, HM. "Robust IR-based detection of stable and fractionally populated G-C+ and A-T Hoogsteen base pairs in duplex DNA." FEBS letters 591.12 (June 2017): 1770-1784. (Letter) Full Text

Vaidyanathan, PP, AlSadhan, I, Merriman, DK, Al-Hashimi, HM, and Herschlag, D. "Pseudouridine and N6-methyladenosine modifications weaken PUF protein/RNA interactions." RNA (New York, N.Y.) 23.5 (May 2017): 611-618. Full Text

Patwardhan, NN, Ganser, LR, Kapral, GJ, Eubanks, CS, Lee, J, Sathyamoorthy, B, Al-Hashimi, HM, and Hargrove, AE. "Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR." MedChemComm 8.5 (May 2017): 1022-1036. Full Text

Sathyamoorthy, B, Shi, H, Zhou, H, Xue, Y, Rangadurai, A, Merriman, DK, and Al-Hashimi, HM. "Insights into Watson-Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m1A." Nucleic acids research 45.9 (May 2017): 5586-5601. Full Text

Szymanski, ES, Kimsey, IJ, and Al-Hashimi, HM. "Direct NMR Evidence that Transient Tautomeric and Anionic States in dG·dT Form Watson-Crick-like Base Pairs." Journal of the American Chemical Society 139.12 (March 14, 2017): 4326-4329. Full Text

Ganser, LR, and Al-Hashimi, HM. "HIV-1 leader RNA dimeric interface revealed by NMR." Proceedings of the National Academy of Sciences of the United States of America 113.47 (November 11, 2016): 13263-13265. Full Text

Shakya, A, Al-Hashimi, HM, and Banaszak Holl, MM. "Three RNA Microenvironments Detected in Fluxional Gene Delivery Polyplex Nanoassemblies." ACS Macro Letters 5.10 (October 18, 2016): 1104-1108. Full Text

Gracia, B, Xue, Y, Bisaria, N, Herschlag, D, Al-Hashimi, HM, and Russell, R. "RNA Structural Modules Control the Rate and Pathway of RNA Folding and Assembly." Journal of molecular biology 428.20 (October 2016): 3972-3985. Full Text

Zhou, H, Kimsey, IJ, Nikolova, EN, Sathyamoorthy, B, Grazioli, G, McSally, J, Bai, T, Wunderlich, CH, Kreutz, C, Andricioaei, I, and Al-Hashimi, HM. "m(1)A and m(1)G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs." Nature structural & molecular biology 23.9 (September 2016): 803-810. Full Text

Merriman, DK, Xue, Y, Yang, S, Kimsey, IJ, Shakya, A, Clay, M, and Al-Hashimi, HM. "Shortening the HIV-1 TAR RNA Bulge by a Single Nucleotide Preserves Motional Modes over a Broad Range of Time Scales." Biochemistry 55.32 (August 2016): 4445-4456. Full Text

Pages

Goh, GB, Nikolova, EN, Al-Hashimi, H, and Brooks, CL. "Elucidating transient protonated GC(+) Hoogstein base pairs in canonical DNA duplexes." April 7, 2013.