Faculty Profiles

Hashim Al-Hashimi
Professor of Chemistry

Overview

Education:

Ph.D., Yale University 2000

Stelling, Allison L., et al. “Infrared Spectroscopic Observation of a G-C+ Hoogsteen Base Pair in the DNA:TATA-Box Binding Protein Complex Under Solution Conditions..” Angew Chem Int Ed Engl, vol. 58, no. 35, Aug. 2019, pp. 12010–13. Pubmed, doi:10.1002/anie.201902693. Full Text

Ganser, Laura R., et al. “The roles of structural dynamics in the cellular functions of RNAs..” Nat Rev Mol Cell Biol, vol. 20, no. 8, Aug. 2019, pp. 474–89. Pubmed, doi:10.1038/s41580-019-0136-0. Full Text

Chu, Chia-Chieh, et al. “Dynamic ensemble of HIV-1 RRE stem IIB reveals non-native conformations that disrupt the Rev-binding site..” Nucleic Acids Res, vol. 47, no. 13, July 2019, pp. 7105–17. Pubmed, doi:10.1093/nar/gkz498. Full Text

Rangadurai, Atul, et al. “Characterizing micro-to-millisecond chemical exchange in nucleic acids using off-resonance R1ρ relaxation dispersion..” Prog Nucl Magn Reson Spectrosc, vol. 112–113, June 2019, pp. 55–102. Pubmed, doi:10.1016/j.pnmrs.2019.05.002. Full Text

Fick, Robert J., et al. “Structural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1..” Biochemistry, vol. 58, no. 16, Apr. 2019, pp. 2152–59. Pubmed, doi:10.1021/acs.biochem.8b01141. Full Text

Zhou, Huiqing, et al. “Characterizing Watson-Crick versus Hoogsteen Base Pairing in a DNA-Protein Complex Using Nuclear Magnetic Resonance and Site-Specifically 13C- and 15N-Labeled DNA..” Biochemistry, vol. 58, no. 15, Apr. 2019, pp. 1963–74. Pubmed, doi:10.1021/acs.biochem.9b00027. Full Text

Travis, Brady, et al. “The RRM of the kRNA-editing protein TbRGG2 uses multiple surfaces to bind and remodel RNA..” Nucleic Acids Res, vol. 47, no. 4, Feb. 2019, pp. 2130–42. Pubmed, doi:10.1093/nar/gky1259. Full Text

Strebitzer, Elisabeth, et al. “5-Oxyacetic Acid Modification Destabilizes Double Helical Stem Structures and Favors Anionic Watson-Crick like cmo5 U-G Base Pairs..” Chemistry, vol. 24, no. 71, Dec. 2018, pp. 18903–06. Pubmed, doi:10.1002/chem.201805077. Full Text

Rangadurai, Atul, et al. “Why are Hoogsteen base pairs energetically disfavored in A-RNA compared to B-DNA?.” Nucleic Acids Res, vol. 46, no. 20, Nov. 2018, pp. 11099–114. Pubmed, doi:10.1093/nar/gky885. Full Text

Pages

Goh, Garrett B., et al. “Elucidating transient protonated GC(+) Hoogstein base pairs in canonical DNA duplexes.” Abstracts of Papers of the American Chemical Society, vol. 245, 2013.