Faculty Profiles

Eric John Toone
Eric John Toone
Professor Emeritus of Chemistry
Office: 
139 Piney Ridge Rd, Clarksville, VA 23927
Phone: 
(919) 414-4337
Fax: 
(919) 660-1591
eric.toone@duke.edu
Breakthrough Energy Ventures
Research Interests: 

Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. The study of these problems makes use of synthetic organic chemistry, traditional enzymology, isothermal titration microcalorimetry, and the techniques of directed evolution.

Overview

Education:

Ph.D., University of Toronto (Canada) 1988

M.S., University of Toronto (Canada) 1985

B.S., University of Guelph (Canada) 1983

Research Areas:
Synthesis, Physical, Organic

Lemaître, Nadine, et al. “Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC.” Mbio, vol. 8, no. 4, July 2017. Pubmed, doi:10.1128/mBio.00674-17. Full Text Open Access Copy

Titecat, Marie, et al. “High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors.” J Antimicrob Chemother, vol. 71, no. 10, Oct. 2016, pp. 2874–82. Pubmed, doi:10.1093/jac/dkw210. Full Text Open Access Copy

Liang, Xiaofei, et al. “A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058.” J Org Chem, vol. 81, no. 10, May 2016, pp. 4393–98. Pubmed, doi:10.1021/acs.joc.6b00589. Full Text Open Access Copy

Lee, Chul-Jin, et al. “Drug design from the cryptic inhibitor envelope.” Nat Commun, vol. 7, Feb. 2016, p. 10638. Pubmed, doi:10.1038/ncomms10638. Full Text Open Access Copy

King, Jason R., et al. “Specific binding at the cellulose binding module-cellulose interface observed by force spectroscopy.” Langmuir : The Acs Journal of Surfaces and Colloids, vol. 31, no. 11, Mar. 2015, pp. 3431–40. Epmc, doi:10.1021/la504836u. Full Text

Sund, J. B., et al. “Diamond surface functionalization with biomimicry - Amine surface tether and thiol moiety for electrochemical sensors.” Applied Surface Science, vol. 301, May 2014, pp. 293–99. Scopus, doi:10.1016/j.apsusc.2014.02.067. Full Text

Bowers, C. M., et al. “Structural Modifications in Bilayered Molecular Systems Lead to Predictable Changes in Their Electronic Properties.” Advanced Materials Interfaces, vol. 1, no. 2, Apr. 2014. Scopus, doi:10.1002/admi.201300109. Full Text

Lee, Chul-Jin, et al. “Structural basis of the promiscuous inhibitor susceptibility of Escherichia coli LpxC.” Acs Chem Biol, vol. 9, no. 1, Jan. 2014, pp. 237–46. Pubmed, doi:10.1021/cb400067g. Full Text

Sund, J. B., et al. “Diamond surface functionalization with biomimicry - Amine surface tether and thiol moiety for electrochemical sensors.” Applied Surface Science, 2014.

Xia, Wenle, et al. “Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis.” Plos One, vol. 9, no. 2, 2014, p. e88983. Pubmed, doi:10.1371/journal.pone.0088983. Full Text

Pages

Toone, E. J. Preface. Vol. 78 1, 2011.

Toone, E. J. Advances in Enzymology and Related Areas of Molecular Biology. Vol. 78, 2011, pp. 1–548. Scopus, doi:10.1002/9781118105771. Full Text

Toone, E. J. Advances in Enzymology and Related Areas of Molecular Biology. Vol. 77, 2011, pp. 1–418. Scopus, doi:10.1002/9780470920541. Full Text

Toone, E. J. Advances in Enzymology: And Related Areas of Molecular Biology. Vol. 75, 2010, pp. 1–314. Scopus, doi:10.1002/9780471224464. Full Text

Toone, E. J. Advances in enzymology and related areas of molecular biology. Vol. 76, 2008, pp. 1–272. Scopus, doi:10.1002/9780470392881. Full Text

Broder, J. Preface. 2011, pp. xi–xii. Scival, doi:10.1016/B978-1-4160-6113-7.10024-9. Full Text

Burkhalter, N. F., et al. “Protein-carbohydrate interaction: Fundamental considerations.” Carbohydrates in Chemistry and Biology, vol. 2–4, 2008, pp. 863–914. Scopus, doi:10.1002/9783527618255.ch31. Full Text

Dodds, D. R., and P. E. J. Toone. Preface. Vol. 2, 1994, p. xiii. Scopus, doi:10.1016/0968-0896(94)80002-2. Full Text

Smith, A. D., et al. “Preface.” Smith’S Textbook of Endourology: 3rd Edition, vol. 1–2, 5 Jan. 2012. Scopus, doi:10.1002/9781444345148. Full Text