Faculty Profiles

Eric John Toone
Eric John Toone
Professor Emeritus of Chemistry
Office: 
139 Piney Ridge Rd, Clarksville, VA 23927
Phone: 
(919) 414-4337
Fax: 
(919) 660-1591
eric.toone@duke.edu
Breakthrough Energy Ventures
Research Interests: 

Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. The study of these problems makes use of synthetic organic chemistry, traditional enzymology, isothermal titration microcalorimetry, and the techniques of directed evolution.

Overview

Education:

Ph.D., University of Toronto (Canada) 1988

M.S., University of Toronto (Canada) 1985

B.S., University of Guelph (Canada) 1983

Research Areas:
Synthesis, Physical, Organic

Choi, B. Y., et al. “Analysis of S-nitrosothiol decomposition.” Proceedings 50th Asms Conference on Mass Spectrometry and Allied Topics, Dec. 2002, pp. 799–800.

Stamler, Jonathan S., and Eric J. Toone. “The decomposition of thionitrites.” Curr Opin Chem Biol, vol. 6, no. 6, Dec. 2002, pp. 779–85. Pubmed, doi:10.1016/s1367-5931(02)00383-6. Full Text

Griffiths, Jennifer S., et al. “Cloning, isolation and characterization of the Thermotoga maritima KDPG aldolase.” Bioorganic & Medicinal Chemistry, vol. 10, no. 3, Mar. 2002, pp. 545–50. Epmc, doi:10.1016/s0968-0896(01)00307-8. Full Text

Lundquist, Joseph J., and Eric J. Toone. “The cluster glycoside effect.” Chemical Reviews, vol. 102, no. 2, Feb. 2002, pp. 555–78. Epmc, doi:10.1021/cr000418f. Full Text

Bartberger, M. D., et al. “S-N dissociation energies of S-nitrosothiols: on the origins of nitrosothiol decomposition rates.” J Am Chem Soc, vol. 123, no. 36, Sept. 2001, pp. 8868–69. Pubmed, doi:10.1021/ja0109390. Full Text

Moya, M. P., et al. “S-nitrosothiol repletion by an inhaled gas regulates pulmonary function.” Proc Natl Acad Sci U S A, vol. 98, no. 10, May 2001, pp. 5792–97. Pubmed, doi:10.1073/pnas.091109498. Full Text

DiTusa, C. A., et al. “Thermodynamics of metal ion binding. 1. Metal ion binding by wild-type carbonic anhydrase.” Biochemistry, vol. 40, no. 18, May 2001, pp. 5338–44. Epmc, doi:10.1021/bi001731e. Full Text

DiTusa, C. A., et al. “Thermodynamics of metal ion binding. 2. Metal ion binding by carbonic anhydrase variants.” Biochemistry, vol. 40, no. 18, May 2001, pp. 5345–51. Epmc, doi:10.1021/bi0017327. Full Text

Wymer, N., et al. “Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.” Structure (London, England : 1993), vol. 9, no. 1, Jan. 2001, pp. 1–9. Epmc, doi:10.1016/s0969-2126(00)00555-4. Full Text

Ditusa, C. A., et al. “Thermodynamics of Metal Ion Bonding. II. Metal Ion Binding by Mutated Carbonic Anhydrases.” Biochemistry, vol. 40, no. 18, 2001, pp. 5345–51.

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