Faculty Profiles

Eric John Toone
Eric John Toone
Professor Emeritus of Chemistry
Office: 
139 Piney Ridge Rd, Clarksville, VA 23927
Phone: 
(919) 414-4337
Fax: 
(919) 660-1591
eric.toone@duke.edu
Breakthrough Energy Ventures
Research Interests: 

Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. The study of these problems makes use of synthetic organic chemistry, traditional enzymology, isothermal titration microcalorimetry, and the techniques of directed evolution.

Overview

Education:

Ph.D., University of Toronto (Canada) 1988

M.S., University of Toronto (Canada) 1985

B.S., University of Guelph (Canada) 1983

Research Areas:
Synthesis, Physical, Organic

Mori, T., et al. “Synthesis of carbosilane dendrimers having peripheral mannose and mannobiose.” Tetrahedron, vol. 61, no. 11, Mar. 2005, pp. 2751–60. Scopus, doi:10.1016/j.tet.2005.01.090. Full Text

Gooden, David M., et al. “C-nitroso compounds: synthesis, physicochemical properties and biological activities.” Current Topics in Medicinal Chemistry, vol. 5, no. 7, Jan. 2005, pp. 687–705. Epmc, doi:10.2174/1568026054679353. Full Text

Snyder, P. W., et al. “Quantitative determination of analytes by force microscopy.” J. Am. Chem. Soc., 2005.

Griffiths, Jennifer S., et al. “A bacterial selection for the directed evolution of pyruvate aldolases.” Bioorganic & Medicinal Chemistry, vol. 12, no. 15, Aug. 2004, pp. 4067–74. Epmc, doi:10.1016/j.bmc.2004.05.034. Full Text

Perry, J. L., et al. “Binding of ochratoxin a to human serum albumin stabilized by a protein-ligand ion pair.” Journal of Physical Chemistry B, vol. 107, no. 31, Aug. 2003, pp. 7884–88.

Debenham, Sheryl D., et al. “Solid-phase synthesis for the identification of high-affinity bivalent lectin ligands.” The Journal of Organic Chemistry, vol. 68, no. 15, July 2003, pp. 5805–11. Epmc, doi:10.1021/jo0207271. Full Text

Houk, K. N., et al. “Nitroxyl disulfides, novel intermediates in transnitrosation reactions.” J Am Chem Soc, vol. 125, no. 23, June 2003, pp. 6972–76. Pubmed, doi:10.1021/ja029655l. Full Text

Christensen, Trine, et al. “Additivity and the physical basis of multivalency effects: a thermodynamic investigation of the calcium EDTA interaction.” Journal of the American Chemical Society, vol. 125, no. 24, June 2003, pp. 7357–66. Epmc, doi:10.1021/ja021240c. Full Text

Christensen, Trine, and Eric J. Toone. “Calorimetric evaluation of protein-carbohydrate affinities.” Methods in Enzymology, vol. 362, Jan. 2003, pp. 486–504. Epmc, doi:10.1016/s0076-6879(03)01032-2. Full Text

Lundquist, J. J., et al. “Towards high affinity carbohydrate-binding proteins: Directed evolution of murine galectin-3.” Canadian Journal of Chemistry, vol. 80, no. 8, Dec. 2002, pp. 999–1009. Scopus, doi:10.1139/v02-086. Full Text

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