Faculty Profiles

Eric John Toone
Eric John Toone
Professor Emeritus of Chemistry
Office: 
139 Piney Ridge Rd, Clarksville, VA 23927
Phone: 
(919) 414-4337
Fax: 
(919) 660-1591
eric.toone@duke.edu
Breakthrough Energy Ventures
Research Interests: 

Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. The study of these problems makes use of synthetic organic chemistry, traditional enzymology, isothermal titration microcalorimetry, and the techniques of directed evolution.

Overview

Education:

Ph.D., University of Toronto (Canada) 1988

M.S., University of Toronto (Canada) 1985

B.S., University of Guelph (Canada) 1983

Research Areas:
Synthesis, Physical, Organic

Liang, Xiaofei, et al. “Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold.” Bioorg Med Chem, vol. 19, no. 2, Jan. 2011, pp. 852–60. Pubmed, doi:10.1016/j.bmc.2010.12.017. Full Text

Toone, Eric J. “Advances in enzymology and related areas of molecular biology. Preface.” Advances in Enzymology and Related Areas of Molecular Biology, vol. 78, Jan. 2011, pp. ix–xi.

Toone, Eric J. “Bacterial infection remains a leading cause of death in both Western and developing world. Preface.” Advances in Enzymology and Related Areas of Molecular Biology, vol. 77, Jan. 2011, pp. xi–xiii.

Bowers, Carleen M., et al. “Soft lithographic functionalization and patterning oxide-free silicon and germanium.” Journal of Visualized Experiments : Jove, no. 58, Jan. 2011, pp. 68–71. Epmc, doi:10.3791/3478. Full Text

Colomer, Josep, et al. “Identification and inhibitory properties of a novel Ca(2+)/calmodulin antagonist.” Biochemistry, vol. 49, no. 19, May 2010, pp. 4244–54. Epmc, doi:10.1021/bi1001213. Full Text Open Access Copy

Shestopalov, Alexander A., et al. “Catalytic microcontact printing on chemically functionalized H-terminated silicon.” Langmuir : The Acs Journal of Surfaces and Colloids, vol. 26, no. 3, Feb. 2010, pp. 1449–51. Epmc, doi:10.1021/la903465f. Full Text Open Access Copy

Toone, E. J. “Forcing a closer look.” Biopolymers, vol. 93, no. 1, Jan. 2010. Scopus, doi:10.1002/bip.21330. Full Text

Wilfong, Erin M., et al. “A single step purification for autolytic zinc proteinases.” Bioorganic & Medicinal Chemistry Letters, vol. 20, no. 1, Jan. 2010, pp. 280–82. Epmc, doi:10.1016/j.bmcl.2009.10.114. Full Text

Shestopalov, Alexander A., et al. “Inkless microcontact printing on SAMs of Boc- and TBS-protected thiols.” Nano Letters, vol. 10, no. 1, Jan. 2010, pp. 43–46. Epmc, doi:10.1021/nl902588d. Full Text Open Access Copy

Rivera, M., et al. “Minimizing tip-sample contact force in automated atomic force microscope based force spectroscopy.” Proceedings of the Asme Design Engineering Technical Conference, vol. 6, Dec. 2009, pp. 731–36. Scopus, doi:10.1115/DETC2009-87378. Full Text

Pages