Faculty Profiles

Eric John Toone
Eric John Toone
Professor Emeritus of Chemistry
Office: 
139 Piney Ridge Rd, Clarksville, VA 23927
Phone: 
(919) 414-4337
Fax: 
(919) 660-1591
eric.toone@duke.edu
Breakthrough Energy Ventures
Research Interests: 

Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. The study of these problems makes use of synthetic organic chemistry, traditional enzymology, isothermal titration microcalorimetry, and the techniques of directed evolution.

Overview

Education:

Ph.D., University of Toronto (Canada) 1988

M.S., University of Toronto (Canada) 1985

B.S., University of Guelph (Canada) 1983

Research Areas:
Synthesis, Physical, Organic

Lundquist, J. J., et al. “Multivalency effects in protein--carbohydrate interaction: the binding of the Shiga-like toxin 1 binding subunit to multivalent C-linked glycopeptides.” The Journal of Organic Chemistry, vol. 65, no. 24, Dec. 2000, pp. 8245–50. Epmc, doi:10.1021/jo000943e. Full Text

Bartberger, M. D., et al. “Theory, spectroscopy, and crystallographic analysis of S-nitrosothiols: Conformational distribution dictates spectroscopic behavior [7].” Journal of the American Chemical Society, vol. 122, no. 24, June 2000, pp. 5889–90. Scopus, doi:10.1021/ja994476y. Full Text

Trzaska, S. M., et al. “Microcalorimetric determination of thermodynamic parameters for ionophore-siderophore host-guest complex formation.” Inorganic Chemistry, vol. 39, no. 6, Mar. 2000, pp. 1071–75. Epmc, doi:10.1021/ic9908571. Full Text

Debenham, S. D., and E. J. Toone. “Regioselective reduction of 4,6-O-benzylidenes using triethylsilane and BF3.Et2O.” Tetrahedron Asymmetry, vol. 11, no. 2, Feb. 2000, pp. 385–87. Scopus, doi:10.1016/S0957-4166(99)00584-4. Full Text

Wymer, N., and E. J. Toone. “Enzyme-catalyzed synthesis of carbohydrates.” Current Opinion in Chemical Biology, vol. 4, no. 1, Feb. 2000, pp. 110–19. Epmc, doi:10.1016/s1367-5931(99)00061-7. Full Text

Corbell, J. B., et al. “A comparison of biological and calorimetric analyses of multivalent glycodendrimer ligands for concanavalin A.” Tetrahedron Asymmetry, vol. 11, no. 1, Jan. 2000, pp. 95–111. Scopus, doi:10.1016/S0957-4166(99)00589-3. Full Text

Debenham, S., and E. J. Toone. “A Facile Method for the Reductive Deprotection of Carbohydrate Benzylidene Protecting Groups.” Tetrahedron Asymm., 2000, pp. 385–87.

Corbell, J. B., et al. “Biological and Calorimetric Analysis of Multivalent Glycodendrimers Ligands for Concanavalin A.” Tetrahedron Asymm., vol. 11, 2000, pp. 95–111.

Lundquist, J. J., et al. “Calorimetric and Biological Evaluation of Shigalike Toxin1 Binding to Multivalent C-Linked Glycopeptides.” J. Org. Chem., vol. 65, 2000, pp. 8245–50.

Wymer, N., and E. J. Toone. “Enzymatic Carbohydrate Synthesis.” Current Opinion in Chemical Biology, vol. 4, 2000, pp. 110–19.

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