Faculty Profiles

Eric John Toone
Eric John Toone
Professor Emeritus of Chemistry
Office: 
139 Piney Ridge Rd, Clarksville, VA 23927
Phone: 
(919) 414-4337
Fax: 
(919) 660-1591
eric.toone@duke.edu
Breakthrough Energy Ventures
Research Interests: 

Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. The study of these problems makes use of synthetic organic chemistry, traditional enzymology, isothermal titration microcalorimetry, and the techniques of directed evolution.

Overview

Education:

Ph.D., University of Toronto (Canada) 1988

M.S., University of Toronto (Canada) 1985

B.S., University of Guelph (Canada) 1983

Research Areas:
Synthesis, Physical, Organic

Snyder, Phillip W., et al. “Biocatalytic microcontact printing.” The Journal of Organic Chemistry, vol. 72, no. 19, Sept. 2007, pp. 7459–61. Epmc, doi:10.1021/jo0711541. Full Text

Matsuoka, K., et al. “Practical synthesis of fully protected globotriaose and its glycopolymers.” Carbohydrate Polymers, vol. 69, no. 2, June 2007, pp. 326–35. Scopus, doi:10.1016/j.carbpol.2006.10.011. Full Text

Snyder, Phillip W., et al. “A stochastic, cantilever approach to the evaluation of solution phase thermodynamic quantities.” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 8, Feb. 2007, pp. 2579–84. Epmc, doi:10.1073/pnas.0606604104. Full Text

Cheryian, M., et al. “Substrate specificity of the electrophilic binding site of KDPG aldolase is altered by mutagenesis (Submitted).” Bioorg. Med. Chem., 2007.

Walters, Matthew J., and Eric J. Toone. “Pyruvate aldolases in chiral carbon-carbon bond formation.” Nature Protocols, vol. 2, no. 7, Jan. 2007, pp. 1825–30. Epmc, doi:10.1038/nprot.2007.260. Full Text

Perry, Jennifer L., et al. “Binding of warfarin influences the acid-base equilibrium of H242 in sudlow site I of human serum albumin.” Photochemistry and Photobiology, vol. 82, no. 5, Sept. 2006, pp. 1365–69. Epmc, doi:10.1562/2006-02-23-ra-811. Full Text

Fullerton, Stephen W. B., et al. “Mechanism of the Class I KDPG aldolase.” Bioorganic & Medicinal Chemistry, vol. 14, no. 9, May 2006, pp. 3002–10. Epmc, doi:10.1016/j.bmc.2005.12.022. Full Text

Pamula, V. K., et al. “A droplet-based lab-on-a-chip for colorimetric detection of nitroaromatic explosives.” Proceedings of the Ieee International Conference on Micro Electro Mechanical Systems (Mems), Oct. 2005, pp. 722–25. Scopus, doi:10.1109/MEMSYS.2005.1454031. Full Text

Zhao, Yi-Lei, et al. “Nitrosonium-catalyzed decomposition of s-nitrosothiols in solution: a theoretical and experimental study.” Journal of the American Chemical Society, vol. 127, no. 31, Aug. 2005, pp. 10917–24. Epmc, doi:10.1021/ja050018f. Full Text

Winter-Vann, Ann M., et al. “A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.” Proc Natl Acad Sci U S A, vol. 102, no. 12, Mar. 2005, pp. 4336–41. Pubmed, doi:10.1073/pnas.0408107102. Full Text

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