Faculty Profiles

Eric John Toone
Eric John Toone
Professor Emeritus of Chemistry
Office: 
139 Piney Ridge Rd, Clarksville, VA 23927
Phone: 
(919) 414-4337
Fax: 
(919) 660-1591
eric.toone@duke.edu
Breakthrough Energy Ventures
Research Interests: 

Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. The study of these problems makes use of synthetic organic chemistry, traditional enzymology, isothermal titration microcalorimetry, and the techniques of directed evolution.

Overview

Education:

Ph.D., University of Toronto (Canada) 1988

M.S., University of Toronto (Canada) 1985

B.S., University of Guelph (Canada) 1983

Research Areas:
Synthesis, Physical, Organic

Wang, Y., et al. “Correction to "Enthalpic Signature of Methonium Desolvation Revealed in a Synthetic Host-Guest System Based on Cucurbit[7]uril".” J Am Chem Soc, vol. 135, no. 46, Nov. 2013, p. 17650. Pubmed, doi:10.1021/ja408346j. Full Text

Liang, Xiaofei, et al. “Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors.” J Med Chem, vol. 56, no. 17, Sept. 2013, pp. 6954–66. Pubmed, doi:10.1021/jm4007774. Full Text

Grant, Gerald A., et al. “The 62nd Annual Meeting of the Congress of Neurological Surgeons was held in Chicago, Illinois from October 6-10, 2012. Preface.” Neurosurgery, vol. 60 Suppl 1, Aug. 2013, p. v. Pubmed, doi:10.1227/NEU.0000000000000006. Full Text

Toone, Eric, and Han de Winde. “Energy biotechnology in 2013: advanced technology development for breakthroughs in fuels and chemicals production.” Current Opinion in Biotechnology, vol. 24, no. 3, June 2013, pp. 367–68. Epmc, doi:10.1016/j.copbio.2013.04.009. Full Text

Bowers, Carleen M., et al. “Effect of compressive force on unbinding specific protein-ligand complexes with force spectroscopy.” The Journal of Physical Chemistry. B, vol. 117, no. 17, May 2013, pp. 4755–62. Epmc, doi:10.1021/jp309393s. Full Text

Wang, Yi, et al. “Enthalpic signature of methonium desolvation revealed in a synthetic host-guest system based on cucurbit[7]uril.” Journal of the American Chemical Society, vol. 135, no. 16, Apr. 2013, pp. 6084–91. Epmc, doi:10.1021/ja311327v. Full Text

Wilfong, Erin M., et al. “An enthalpic basis of additivity in biphenyl hydroxamic acid ligands for stromelysin-1.” Bioorganic & Medicinal Chemistry Letters, vol. 22, no. 20, Oct. 2012, pp. 6521–24. Epmc, doi:10.1016/j.bmcl.2012.05.032. Full Text

Bowers, Carleen M., et al. “A general and efficient cantilever functionalization technique for AFM molecular recognition studies.” Biopolymers, vol. 97, no. 10, Oct. 2012, pp. 761–65. Epmc, doi:10.1002/bip.22061. Full Text

Bowers, Carleen M., et al. “Multicomponent patterning of indium tin oxide.” Acs Applied Materials & Interfaces, vol. 4, no. 8, Aug. 2012, pp. 3932–37. Epmc, doi:10.1021/am300768f. Full Text

Cheriyan, Manoj, et al. “Improving upon nature: active site remodeling produces highly efficient aldolase activity toward hydrophobic electrophilic substrates.” Biochemistry, vol. 51, no. 8, Feb. 2012, pp. 1658–68. Epmc, doi:10.1021/bi201899b. Full Text

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