Faculty Profiles

Eric John Toone
Professor Emeritus of Chemistry
Office: 
3236 French Science Center, Durham, NC 27708
Phone: 
(919) 660-1506
Fax: 
(919) 660-1591

Overview

Education:

Ph.D., University of Toronto (Canada) 1988

M.S., University of Toronto (Canada) 1985

B.S., University of Guelph (Canada) 1983

Research Areas:
Synthesis, Physical, Organic

Lemaître, N, Liang, X, Najeeb, J, Lee, C-J, Titecat, M, Leteurtre, E, Simonet, M, Toone, EJ, Zhou, P, and Sebbane, F. "Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC." Mbio 8.4 (July 25, 2017). Full Text Open Access Copy

Titecat, M, Liang, X, Lee, C-J, Charlet, A, Hocquet, D, Lambert, T, Pagès, J-M, Courcol, R, Sebbane, F, Toone, EJ, Zhou, P, and Lemaitre, N. "High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors." The Journal of antimicrobial chemotherapy 71.10 (October 2016): 2874-2882. Full Text Open Access Copy

Liang, X, Gopalaswamy, R, Navas, F, Toone, EJ, and Zhou, P. "A Scalable Synthesis of the Difluoromethyl-allo-threonyl Hydroxamate-Based LpxC Inhibitor LPC-058." The Journal of organic chemistry 81.10 (May 2016): 4393-4398. Full Text Open Access Copy

Lee, C-J, Liang, X, Wu, Q, Najeeb, J, Zhao, J, Gopalaswamy, R, Titecat, M, Sebbane, F, Lemaitre, N, Toone, EJ, and Zhou, P. "Drug design from the cryptic inhibitor envelope." Nature communications 7 (February 25, 2016): 10638-. Full Text Open Access Copy

King, JR, Bowers, CM, and Toone, EJ. "Specific binding at the cellulose binding module-cellulose interface observed by force spectroscopy." Langmuir : the ACS journal of surfaces and colloids 31.11 (March 12, 2015): 3431-3440. Full Text

Sund, JB, Causey, CP, Wolter, SD, Parker, CB, Stoner, BR, Toone, EJ, and Glass, JT. "Diamond surface functionalization with biomimicry - Amine surface tether and thiol moiety for electrochemical sensors." Applied Surface Science 301 (May 15, 2014): 293-299. Full Text

Sund, JB, Causey, CP, Wolter, SD, Parker, CB, Stoner, BR, Toone, EJ, and Glass, JT. "Diamond surface functionalization with biomimicry – Amine surface tether and thiol moiety for electrochemical sensors." Applied Surface Science 301 (May 2014): 293-299. Full Text

Bowers, CM, Zhang, M, Lyubarskaya, Y, Toone, EJ, Tang, C, and Shestopalov, AA. "Structural Modifications in Bilayered Molecular Systems Lead to Predictable Changes in Their Electronic Properties." Advanced Materials Interfaces 1.2 (April 2014): 1300109-1300109. Full Text

Lee, C-J, Liang, X, Gopalaswamy, R, Najeeb, J, Ark, ED, Toone, EJ, and Zhou, P. "Structural basis of the promiscuous inhibitor susceptibility of Escherichia coli LpxC." Acs Chemical Biology 9.1 (January 2014): 237-246. Full Text

Xia, W, Gooden, D, Liu, L, Zhao, S, Soderblom, EJ, Toone, EJ, Beyer, WF, Walder, H, and Spector, NL. "Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis." Plos One 9.2 (January 2014): e88983-null. Full Text

Pages

Broder, J. "Preface." 2011. xi-xii. Full Text

Burkhalter, NF, Dimick, SM, and Toone, EJ. "Protein-carbohydrate interaction: Fundamental considerations." Carbohydrates in Chemistry and Biology. April 24, 2008. 863-914. Full Text

Dodds, DR, and Toone, PEJ. "Preface." January 1, 1994. xiii-null. Full Text