Faculty Profiles

Emily Rose Derbyshire
Assistant Professor of Chemistry
Office: 
3218 French Science Center, Durham, NC 27708
Phone: 
(919) 660-1511

Overview

Education:

Nih Postdoctoral Fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School 2009 - 2014

Ph.D., University of California at Berkeley 2008

B.S., Trinity College 2002

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Totzke, J, Gurbani, D, Raphemot, R, Hughes, PF, Bodoor, K, Carlson, DA, Loiselle, DR, Bera, AK, Eibschutz, LS, Perkins, MM, Eubanks, AL, Campbell, PL, Fox, DA, Westover, KD, Haystead, TAJ, and Derbyshire, ER. "Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease." Cell chemical biology 24.8 (August 2017): 1029-1039.e7. Full Text

Kato, N, Comer, E, Sakata-Kato, T, Sharma, A, Sharma, M, Maetani, M, Bastien, J, Brancucci, NM, Bittker, JA, Corey, V, Clarke, D, Derbyshire, ER, Dornan, GL, Duffy, S, Eckley, S, Itoe, MA, Koolen, KMJ, Lewis, TA, Lui, PS, Lukens, AK, Lund, E, March, S, Meibalan, E, Meier, BC, McPhail, JA, Mitasev, B, Moss, EL, Sayes, M, Van Gessel, Y, Wawer, MJ, Yoshinaga, T, Zeeman, A-M, Avery, VM, Bhatia, SN, Burke, JE, Catteruccia, F, Clardy, JC, Clemons, PA, Dechering, KJ, Duvall, JR, Foley, MA, and Gusovsky, F et al. "Diversity-oriented synthesis yields novel multistage antimalarial inhibitors." Nature 538.7625 (October 2016): 344-349. Full Text

Raphemot, R, Posfai, D, and Derbyshire, ER. "Current therapies and future possibilities for drug development against liver-stage malaria." The Journal of clinical investigation 126.6 (June 2016): 2013-2020. (Review) Full Text

Raphemot, R, Lafuente-Monasterio, MJ, Gamo-Benito, FJ, Clardy, J, and Derbyshire, ER. "Discovery of Dual-Stage Malaria Inhibitors with New Targets." Antimicrobial agents and chemotherapy 60.3 (December 14, 2015): 1430-1437. Full Text

Herman, JD, Pepper, LR, Cortese, JF, Estiu, G, Galinsky, K, Zuzarte-Luis, V, Derbyshire, ER, Ribacke, U, Lukens, AK, Santos, SA, Patel, V, Clish, CB, Sullivan, WJ, Zhou, H, Bopp, SE, Schimmel, P, Lindquist, S, Clardy, J, Mota, MM, Keller, TL, Whitman, M, Wiest, O, Wirth, DF, and Mazitschek, R. "The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs." Science translational medicine 7.288 (May 2015): 288ra77-. Full Text

Derbyshire, ER, Zuzarte-Luís, V, Magalhães, AD, Kato, N, Sanschagrin, PC, Wang, J, Zhou, W, Miduturu, CV, Mazitschek, R, Sliz, P, Mota, MM, Gray, NS, and Clardy, J. "Chemical interrogation of the malaria kinome." Chembiochem : a European journal of chemical biology 15.13 (September 2014): 1920-1930. Full Text

Derbyshire, ER, Min, J, Guiguemde, WA, Clark, JA, Connelly, MC, Magalhães, AD, Guy, RK, and Clardya, J. "Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites." Antimicrobial Agents and Chemotherapy 58.3 (March 1, 2014): 1516-1522. Full Text

Derbyshire, ER, Min, J, Guiguemde, WA, Clark, JA, Connelly, MC, Magalhães, AD, Guy, RK, and Clardy, J. "Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites." Antimicrob Agents Chemother 58.3 (2014): 1516-1522. Full Text

Derbyshire, ER, and Clardy, J. "Closing in on a new treatment for sleeping sickness. (Published online)" Elife 2 (July 9, 2013): e01042-. Full Text

Fernhoff, NB, Derbyshire, ER, Underbakke, ES, and Marletta, MA. "Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide." J Biol Chem 287.51 (December 14, 2012): 43053-43062. Full Text

Pages