Faculty Profiles

Emily R. Derbyshire
Assistant Professor of Chemistry
3218 French Science Center, Durham, NC 27708
(919) 660-1511



NIH Postdoctoral Fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School 2009 - 2014

Ph.D., University of California at Berkeley 2008

B.S., Trinity College 2002

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Derbyshire, Emily R., et al. “The next opportunity in anti-malaria drug discovery: the liver stage.Plos Pathogens, vol. 7, no. 9, Sept. 2011, p. e1002178. Epmc, doi:10.1371/journal.ppat.1002178. Full Text

Derbyshire, Emily R., et al. “Probing domain interactions in soluble guanylate cyclase.Biochemistry, vol. 50, no. 20, May 2011, pp. 4281–90. Epmc, doi:10.1021/bi200341b. Full Text

Ibrahim, Mohammed, et al. “Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence.Biochemistry, vol. 49, no. 23, June 2010, pp. 4864–71. Epmc, doi:10.1021/bi100506j. Full Text

Derbyshire, Emily R., et al. “Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding.The Journal of Biological Chemistry, vol. 285, no. 23, June 2010, pp. 17471–78. Epmc, doi:10.1074/jbc.m109.098269. Full Text

Ibrahim, Mohammed, et al. “Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy.Biochemistry, vol. 49, no. 18, May 2010, pp. 3815–23. Epmc, doi:10.1021/bi902214j. Full Text

Fernhoff, Nathaniel B., et al. “A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase.Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 51, Dec. 2009, pp. 21602–07. Epmc, doi:10.1073/pnas.0911083106. Full Text

Derbyshire, Emily R., et al. “Nucleotide regulation of soluble guanylate cyclase substrate specificity.Biochemistry, vol. 48, no. 31, Aug. 2009, pp. 7519–24. Epmc, doi:10.1021/bi900696x. Full Text

Ibrahim, Mohammed, et al. “Interaction of allosteric effectors with soluble guanylate cyclase heme domains: Role of heme distortion and propionate hydrogen bonding on synergistic activation.” Abstracts of Papers of the American Chemical Society, vol. 237, AMER CHEMICAL SOC, Mar. 2009.

Derbyshire, Emily R., and Michael A. Marletta. “Biochemistry of soluble guanylate cyclase.Handbook of Experimental Pharmacology, no. 191, Jan. 2009, pp. 17–31. Epmc, doi:10.1007/978-3-540-68964-5_2. Full Text

Winger, Jonathan A., et al. “The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase.Bmc Structural Biology, vol. 8, Oct. 2008, p. 42. Epmc, doi:10.1186/1472-6807-8-42. Full Text