Faculty Profiles

Emily R. Derbyshire
Assistant Professor of Chemistry
3218 French Science Center, Durham, NC 27708
(919) 660-1511



NIH Postdoctoral Fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School 2009 - 2014

Ph.D., University of California at Berkeley 2008

B.S., Trinity College 2002

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Fernhoff, Nathaniel B., et al. “A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase..” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 51, Dec. 2009, pp. 21602–07. Epmc, doi:10.1073/pnas.0911083106. Full Text

Derbyshire, Emily R., et al. “Nucleotide regulation of soluble guanylate cyclase substrate specificity..” Biochemistry, vol. 48, no. 31, Aug. 2009, pp. 7519–24. Epmc, doi:10.1021/bi900696x. Full Text

Ibrahim, Mohammed, et al. “Interaction of allosteric effectors with soluble guanylate cyclase heme domains: Role of heme distortion and propionate hydrogen bonding on synergistic activation.” Abstracts of Papers of the American Chemical Society, vol. 237, AMER CHEMICAL SOC, Mar. 2009.

Derbyshire, Emily R., and Michael A. Marletta. “Biochemistry of soluble guanylate cyclase..” Handbook of Experimental Pharmacology, no. 191, Jan. 2009, pp. 17–31. Epmc, doi:10.1007/978-3-540-68964-5_2. Full Text

Winger, Jonathan A., et al. “The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase..” Bmc Structural Biology, vol. 8, Oct. 2008. Epmc, doi:10.1186/1472-6807-8-42. Full Text

Derbyshire, Emily R., et al. “Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes..” Biochemistry, vol. 47, no. 12, Mar. 2008, pp. 3892–99. Epmc, doi:10.1021/bi7022943. Full Text

Derbyshire, Emily R., and Michael A. Marletta. “Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide..” The Journal of Biological Chemistry, vol. 282, no. 49, Dec. 2007, pp. 35741–48. Epmc, doi:10.1074/jbc.m705557200. Full Text

Martin, Nathaniel I., et al. “Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1..” Bioorganic & Medicinal Chemistry Letters, vol. 17, no. 17, Sept. 2007, pp. 4938–41. Epmc, doi:10.1016/j.bmcl.2007.06.039. Full Text

Winger, Jonathan A., et al. “Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs..” The Journal of Biological Chemistry, vol. 282, no. 2, Jan. 2007, pp. 897–907. Epmc, doi:10.1074/jbc.m606327200. Full Text

Cary, Stephen P. L., et al. “Nitric oxide signaling: no longer simply on or off..” Trends in Biochemical Sciences, vol. 31, no. 4, Apr. 2006, pp. 231–39. Epmc, doi:10.1016/j.tibs.2006.02.003. Full Text