Faculty Profiles

Emily R. Derbyshire
Assistant Professor of Chemistry
3218 French Science Center, Durham, NC 27708
(919) 660-1511



NIH Postdoctoral Fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School 2009 - 2014

Ph.D., University of California at Berkeley 2008

B.S., Trinity College 2002

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Derbyshire, ER, Fernhoff, NB, Deng, S, and Marletta, MA. "Nucleotide regulation of soluble guanylate cyclase substrate specificity." Biochemistry 48.31 (August 2009): 7519-7524. Full Text

Ibrahim, M, Derbyshire, ER, Marletta, MA, and Spiro, TG. "Interaction of allosteric effectors with soluble guanylate cyclase heme domains: Role of heme distortion and propionate hydrogen bonding on synergistic activation." ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 237 (March 22, 2009).

Derbyshire, ER, and Marletta, MA. "Biochemistry of soluble guanylate cyclase." Handb Exp Pharmacol 191 (2009): 17-31. (Review) Full Text

Winger, JA, Derbyshire, ER, Lamers, MH, Marletta, MA, and Kuriyan, J. "The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase." Bmc Structural Biology 8 (October 7, 2008): 42-null. Full Text

Derbyshire, ER, Gunn, A, Ibrahim, M, Spiro, TG, Britt, RD, and Marletta, MA. "Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes." Biochemistry 47.12 (March 2008): 3892-3899. Full Text

Derbyshire, ER, and Marletta, MA. "Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide." The Journal of Biological Chemistry 282.49 (December 2007): 35741-35748. Full Text

Martin, NI, Derbyshire, ER, and Marletta, MA. "Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1." Bioorg Med Chem Lett 17.17 (September 1, 2007): 4938-4941. Full Text

Winger, JA, Derbyshire, ER, and Marletta, MA. "Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs." The Journal of Biological Chemistry 282.2 (January 2007): 897-907. Full Text

Cary, SPL, Winger, JA, Derbyshire, ER, and Marletta, MA. "Nitric oxide signaling: no longer simply on or off." Trends Biochem Sci 31.4 (April 2006): 231-239. (Review) Full Text

Derbyshire, ER, Tran, R, Mathies, RA, and Marletta, MA. "Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase." Biochemistry 44.49 (December 13, 2005): 16257-16265. Full Text