Faculty Profiles

Emily R. Derbyshire
Assistant Professor of Chemistry
3218 French Science Center, Durham, NC 27708
(919) 660-1511



NIH Postdoctoral Fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School 2009 - 2014

Ph.D., University of California at Berkeley 2008

B.S., Trinity College 2002

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Carr, Gavin, et al. “Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp..” Journal of Natural Products, vol. 75, no. 10, Oct. 2012, pp. 1806–09. Epmc, doi:10.1021/np300380t. Full Text

Derbyshire, Emily R., et al. “Liver-stage malaria parasites vulnerable to diverse chemical scaffolds..” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 22, May 2012, pp. 8511–16. Epmc, doi:10.1073/pnas.1118370109. Full Text

Derbyshire, Emily R., et al. “Characterization of Plasmodium liver stage inhibition by halofuginone..” Chemmedchem, vol. 7, no. 5, May 2012, pp. 844–49. Epmc, doi:10.1002/cmdc.201200045. Full Text

Derbyshire, Emily R., and Michael A. Marletta. “Structure and regulation of soluble guanylate cyclase..” Annual Review of Biochemistry, vol. 81, Jan. 2012, pp. 533–59. Epmc, doi:10.1146/annurev-biochem-050410-100030. Full Text

Dong, Carolyn K., et al. “Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors..” Chemistry & Biology, vol. 18, no. 12, Dec. 2011, pp. 1602–10. Epmc, doi:10.1016/j.chembiol.2011.09.016. Full Text

Derbyshire, Emily R., et al. “The next opportunity in anti-malaria drug discovery: the liver stage..” Plos Pathogens, vol. 7, no. 9, Sept. 2011. Epmc, doi:10.1371/journal.ppat.1002178. Full Text

Derbyshire, Emily R., et al. “Probing domain interactions in soluble guanylate cyclase..” Biochemistry, vol. 50, no. 20, May 2011, pp. 4281–90. Epmc, doi:10.1021/bi200341b. Full Text

Ibrahim, Mohammed, et al. “Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence..” Biochemistry, vol. 49, no. 23, June 2010, pp. 4864–71. Epmc, doi:10.1021/bi100506j. Full Text

Derbyshire, Emily R., et al. “Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding..” The Journal of Biological Chemistry, vol. 285, no. 23, June 2010, pp. 17471–78. Epmc, doi:10.1074/jbc.M109.098269. Full Text

Ibrahim, Mohammed, et al. “Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy..” Biochemistry, vol. 49, no. 18, May 2010, pp. 3815–23. Epmc, doi:10.1021/bi902214j. Full Text