Faculty Profiles

Emily R. Derbyshire
Assistant Professor of Chemistry
3218 French Science Center, Durham, NC 27708
(919) 660-1511



NIH Postdoctoral Fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School 2009 - 2014

Ph.D., University of California at Berkeley 2008

B.S., Trinity College 2002

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Derbyshire, ER, Prudêncio, M, Mota, MM, and Clardy, J. "Liver-stage malaria parasites vulnerable to diverse chemical scaffolds." Proc Natl Acad Sci U S A 109.22 (May 29, 2012): 8511-8516. Full Text

Derbyshire, ER, Mazitschek, R, and Clardy, J. "Characterization of Plasmodium liver stage inhibition by halofuginone." ChemMedChem 7.5 (May 2012): 844-849. Full Text

Derbyshire, ER, and Marletta, MA. "Structure and regulation of soluble guanylate cyclase." Annual Review of Biochemistry 81 (January 2012): 533-559. (Review) Full Text

Dong, CK, Urgaonkar, S, Cortese, JF, Gamo, F-J, Garcia-Bustos, JF, Lafuente, MJ, Patel, V, Ross, L, Coleman, BI, Derbyshire, ER, Clish, CB, Serrano, AE, Cromwell, M, Barker, RH, Dvorin, JD, Duraisingh, MT, Wirth, DF, Clardy, J, and Mazitschek, R. "Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors." Chem Biol 18.12 (December 23, 2011): 1602-1610. Full Text

Derbyshire, ER, Mota, MM, and Clardy, J. "The next opportunity in anti-malaria drug discovery: the liver stage." Plos Pathogens 7.9 (September 22, 2011): e1002178-null. Full Text

Derbyshire, ER, Winter, MB, Ibrahim, M, Deng, S, Spiro, TG, and Marletta, MA. "Probing domain interactions in soluble guanylate cyclase." Biochemistry 50.20 (May 24, 2011): 4281-4290. Full Text

Ibrahim, M, Derbyshire, ER, Soldatova, AV, Marletta, MA, and Spiro, TG. "Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence." Biochemistry 49.23 (June 15, 2010): 4864-4871. Full Text

Derbyshire, ER, Deng, S, and Marletta, MA. "Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding." The Journal of Biological Chemistry 285.23 (June 2010): 17471-17478. Full Text

Ibrahim, M, Derbyshire, ER, Marletta, MA, and Spiro, TG. "Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy." Biochemistry 49.18 (May 2010): 3815-3823. Full Text

Fernhoff, NB, Derbyshire, ER, and Marletta, MA. "A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase." Proc Natl Acad Sci U S A 106.51 (December 22, 2009): 21602-21607. Full Text