Faculty Profiles

Emily R. Derbyshire
Assistant Professor of Chemistry
3218 French Science Center, Durham, NC 27708
(919) 660-1511



NIH Postdoctoral Fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School 2009 - 2014

Ph.D., University of California at Berkeley 2008

B.S., Trinity College 2002

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Derbyshire, Emily R., et al. “Chemical interrogation of the malaria kinome.Chembiochem : A European Journal of Chemical Biology, vol. 15, no. 13, Sept. 2014, pp. 1920–30. Epmc, doi:10.1002/cbic.201400025. Full Text

Derbyshire, Emily R., et al. “Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites.Antimicrobial Agents and Chemotherapy, vol. 58, no. 3, Jan. 2014, pp. 1516–22. Epmc, doi:10.1128/aac.02148-13. Full Text

Derbyshire, Emily R., and Jon Clardy. “Closing in on a new treatment for sleeping sickness.Elife, vol. 2, Jan. 2013, p. e01042. Epmc, doi:10.7554/elife.01042. Full Text

Fernhoff, Nathaniel B., et al. “Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide.The Journal of Biological Chemistry, vol. 287, no. 51, Dec. 2012, pp. 43053–62. Epmc, doi:10.1074/jbc.m112.393892. Full Text

Gunn, Alexander, et al. “Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR).Biochemistry, vol. 51, no. 42, Oct. 2012, pp. 8384–90. Epmc, doi:10.1021/bi300831m. Full Text

Carr, Gavin, et al. “Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.Journal of Natural Products, vol. 75, no. 10, Oct. 2012, pp. 1806–09. Epmc, doi:10.1021/np300380t. Full Text

Derbyshire, Emily R., et al. “Liver-stage malaria parasites vulnerable to diverse chemical scaffolds.Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 22, May 2012, pp. 8511–16. Epmc, doi:10.1073/pnas.1118370109. Full Text

Derbyshire, Emily R., et al. “Characterization of Plasmodium liver stage inhibition by halofuginone.Chemmedchem, vol. 7, no. 5, May 2012, pp. 844–49. Epmc, doi:10.1002/cmdc.201200045. Full Text

Derbyshire, Emily R., and Michael A. Marletta. “Structure and regulation of soluble guanylate cyclase.Annual Review of Biochemistry, vol. 81, Jan. 2012, pp. 533–59. Epmc, doi:10.1146/annurev-biochem-050410-100030. Full Text

Dong, Carolyn K., et al. “Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.Chemistry & Biology, vol. 18, no. 12, Dec. 2011, pp. 1602–10. Epmc, doi:10.1016/j.chembiol.2011.09.016. Full Text