Faculty Profiles

Emily R. Derbyshire
Assistant Professor of Chemistry
Office: 
3218 French Science Center, Durham, NC 27708
Phone: 
(919) 660-1511

Overview

Education:

NIH Postdoctoral Fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School 2009 - 2014

Ph.D., University of California at Berkeley 2008

B.S., Trinity College 2002

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Totzke, Juliane, et al. “Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease..” Cell Chem Biol, vol. 24, no. 8, Aug. 2017, pp. 1029-1039.e7. Pubmed, doi:10.1016/j.chembiol.2017.07.011. Full Text

Kato, Nobutaka, et al. “Diversity-oriented synthesis yields novel multistage antimalarial inhibitors..” Nature, vol. 538, no. 7625, Oct. 2016, pp. 344–49. Epmc, doi:10.1038/nature19804. Full Text

Raphemot, Rene, et al. “Current therapies and future possibilities for drug development against liver-stage malaria..” The Journal of Clinical Investigation, vol. 126, no. 6, June 2016, pp. 2013–20. Epmc, doi:10.1172/JCI82981. Full Text

Raphemot, Rene, et al. “Discovery of Dual-Stage Malaria Inhibitors with New Targets..” Antimicrobial Agents and Chemotherapy, vol. 60, no. 3, Dec. 2015, pp. 1430–37. Epmc, doi:10.1128/AAC.02110-15. Full Text

Herman, Jonathan D., et al. “The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs..” Science Translational Medicine, vol. 7, no. 288, May 2015. Epmc, doi:10.1126/scitranslmed.aaa3575. Full Text

Derbyshire, Emily R., et al. “Chemical interrogation of the malaria kinome..” Chembiochem : A European Journal of Chemical Biology, vol. 15, no. 13, Sept. 2014, pp. 1920–30. Epmc, doi:10.1002/cbic.201400025. Full Text

Derbyshire, Emily R., et al. “Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites..” Antimicrobial Agents and Chemotherapy, vol. 58, no. 3, Jan. 2014, pp. 1516–22. Epmc, doi:10.1128/AAC.02148-13. Full Text

Derbyshire, Emily R., and Jon Clardy. “Closing in on a new treatment for sleeping sickness..” Elife, vol. 2, Jan. 2013. Epmc, doi:10.7554/eLife.01042. Full Text

Fernhoff, Nathaniel B., et al. “Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide..” The Journal of Biological Chemistry, vol. 287, no. 51, Dec. 2012, pp. 43053–62. Epmc, doi:10.1074/jbc.M112.393892. Full Text

Gunn, Alexander, et al. “Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR)..” Biochemistry, vol. 51, no. 42, Oct. 2012, pp. 8384–90. Epmc, doi:10.1021/bi300831m. Full Text

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