Faculty Profiles

Emily R. Derbyshire
Assistant Professor of Chemistry
Office: 
3218 French Science Center, Durham, NC 27708
Phone: 
(919) 660-1511

Overview

Education:

NIH Postdoctoral Fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School 2009 - 2014

Ph.D., University of California at Berkeley 2008

B.S., Trinity College 2002

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Eubanks, AL, Perkins, MM, Sylvester, K, Ganley, JG, Posfai, D, Sanschargrin, PC, Hong, J, Sliz, P, and Derbyshire, ER. "In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors." Chemmedchem (October 16, 2018). Full Text

Ganley, JG, Carr, G, Ioerger, TR, Sacchettini, JC, Clardy, J, and Derbyshire, ER. "Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes." Chembiochem : a European Journal of Chemical Biology 19.15 (August 2018): 1590-1594. Full Text

Posfai, D, Sylvester, K, Reddy, A, Ganley, JG, Wirth, J, Cullen, QE, Dave, T, Kato, N, Dave, SS, and Derbyshire, ER. "Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection." Plos Pathogens 14.5 (May 18, 2018): e1007057-null. Full Text Open Access Copy

Posfai, D, Sylvester, K, Reddy, A, Ganley, JG, Wirth, J, Cullen, QE, Dave, T, Kato, N, Dave, SS, and Derbyshire, ER. "Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection." Plos Pathogens 14.5 (May 1, 2018). (Academic Article) Full Text

Posfai, D, Eubanks, AL, Keim, AI, Lu, K-Y, Wang, GZ, Hughes, PF, Kato, N, Haystead, TA, and Derbyshire, ER. "Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity." Antimicrobial Agents and Chemotherapy 62.4 (April 2018). Full Text

Ganley, JG, Toro-Moreno, M, and Derbyshire, ER. "Exploring the Untapped Biosynthetic Potential of Apicomplexan Parasites." Biochemistry 57.4 (January 2018): 365-375. (Review) Full Text

Totzke, J, Gurbani, D, Raphemot, R, Hughes, PF, Bodoor, K, Carlson, DA, Loiselle, DR, Bera, AK, Eibschutz, LS, Perkins, MM, Eubanks, AL, Campbell, PL, Fox, DA, Westover, KD, Haystead, TAJ, and Derbyshire, ER. "Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease." Cell chemical biology 24.8 (August 2017): 1029-1039.e7. Full Text

Kato, N, Comer, E, Sakata-Kato, T, Sharma, A, Sharma, M, Maetani, M, Bastien, J, Brancucci, NM, Bittker, JA, Corey, V, Clarke, D, Derbyshire, ER, Dornan, GL, Duffy, S, Eckley, S, Itoe, MA, Koolen, KMJ, Lewis, TA, Lui, PS, Lukens, AK, Lund, E, March, S, Meibalan, E, Meier, BC, McPhail, JA, Mitasev, B, Moss, EL, Sayes, M, Van Gessel, Y, Wawer, MJ, Yoshinaga, T, Zeeman, A-M, Avery, VM, Bhatia, SN, Burke, JE, Catteruccia, F, Clardy, JC, Clemons, PA, Dechering, KJ, Duvall, JR, Foley, MA, Gusovsky, F, Kocken, CHM, Marti, M, Morningstar, ML, Munoz, B, Neafsey, DE, Sharma, A, Winzeler, EA, Wirth, DF, Scherer, CA, and Schreiber, SL. "Diversity-oriented synthesis yields novel multistage antimalarial inhibitors." Nature 538.7625 (October 2016): 344-349. Full Text

Raphemot, R, Posfai, D, and Derbyshire, ER. "Current therapies and future possibilities for drug development against liver-stage malaria." The Journal of Clinical Investigation 126.6 (June 2016): 2013-2020. (Review) Full Text

Raphemot, R, Lafuente-Monasterio, MJ, Gamo-Benito, FJ, Clardy, J, and Derbyshire, ER. "Discovery of Dual-Stage Malaria Inhibitors with New Targets." Antimicrobial agents and chemotherapy 60.3 (December 14, 2015): 1430-1437. Full Text

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