Faculty Profiles

Emily R. Derbyshire
Assistant Professor of Chemistry
3218 French Science Center, Durham, NC 27708
(919) 660-1511



NIH Postdoctoral Fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School 2009 - 2014

Ph.D., University of California - Berkeley 2008

B.S., Trinity College 2002

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Lu, Kuan-Yi, et al. “Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death.Elife, vol. 9, Sept. 2020. Epmc, doi:10.7554/elife.56773. Full Text

Ganley, Jack G., et al. “A Systematic Analysis of Mosquito-Microbiome Biosynthetic Gene Clusters Reveals Antimalarial Siderophores that Reduce Mosquito Reproduction Capacity.Cell Chemical Biology, vol. 27, no. 7, July 2020, pp. 817-826.e5. Epmc, doi:10.1016/j.chembiol.2020.06.004. Full Text

Posfai, Dora, et al. “Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3.Cell Chemical Biology, vol. 27, no. 6, June 2020, pp. 719-727.e5. Epmc, doi:10.1016/j.chembiol.2020.03.009. Full Text

Ganley, Jack G., et al. “Coculturing of Mosquito-Microbiome Bacteria Promotes Heme Degradation in Elizabethkingia anophelis.Chembiochem : A European Journal of Chemical Biology, vol. 21, no. 9, May 2020, pp. 1279–84. Epmc, doi:10.1002/cbic.201900675. Full Text

Lu, Kuan-Yi, et al. “Plasmodium chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy.Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 11, Mar. 2020, pp. 5810–17. Epmc, doi:10.1073/pnas.1913525117. Full Text

Lu, Kuan-Yi, and Emily R. Derbyshire. “Tafenoquine: A Step toward Malaria Elimination.Biochemistry, vol. 59, no. 8, Mar. 2020, pp. 911–20. Epmc, doi:10.1021/acs.biochem.9b01105. Full Text

D’Ambrosio, Hannah K., and Emily R. Derbyshire. “Investigating the Role of Class I Adenylate-Forming Enzymes in Natural Product Biosynthesis.Acs Chemical Biology, vol. 15, no. 1, Jan. 2020, pp. 17–27. Epmc, doi:10.1021/acschembio.9b00865. Full Text

Raphemot, Rene, et al. “Discovery of Druggable Host Factors Critical to Plasmodium Liver-Stage Infection.Cell Chemical Biology, vol. 26, no. 9, Sept. 2019, pp. 1253-1262.e5. Epmc, doi:10.1016/j.chembiol.2019.05.011. Full Text

Szamosvári, Dávid, et al. “Close the ring to break the cycle: tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-a]quinolin-5-ones with potent anti-protozoal activity.Chemical Communications (Cambridge, England), vol. 55, no. 49, June 2019, pp. 7009–12. Epmc, doi:10.1039/c9cc01689a. Full Text

Lee, Hyunji, et al. “Synthesis and Analysis of Natural-Product-Like Macrocycles by Tandem Oxidation/Oxa-Conjugate Addition Reactions.Chemistry (Weinheim an Der Bergstrasse, Germany), vol. 25, no. 26, May 2019, pp. 6500–04. Epmc, doi:10.1002/chem.201900620. Full Text


Keim, Allison I., et al. “Heat Shock Protein 90 is Critical for Plasmodium Parasite Liver Stage Development.” Faseb Journal, vol. 31, FEDERATION AMER SOC EXP BIOL, 2017.

Eubanks, Amber L., and Emily R. Derbyshire. “Exploration of Plasmodium Kinases.” Faseb Journal, vol. 30, FEDERATION AMER SOC EXP BIOL, 2016.

Eubanks, Amber L., and Emily R. Derbyshire. “Exploration of Plasmodium Kinases.” Faseb Journal, vol. 30, FEDERATION AMER SOC EXP BIOL, 2016.