Faculty Profiles

Dewey G. McCafferty
Professor of Chemistry
B120 LSRC, Box 90346, 450 Research Drive, Dept. Chemistry, Durham, NC 27708-0346
(919) 660-1516
(919) 660-1605



Ph.D., University of North Carolina at Chapel Hill 1995

B.S., North Carolina State University 1990

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Schmidt, JW, Greenough, A, Burns, M, Luteran, AE, and McCafferty, DG. "Generation of ramoplanin-resistant Staphylococcus aureus." FEMS Microbiol Lett 310.2 (September 1, 2010): 104-111. Full Text

Clancy, KW, Melvin, JA, and McCafferty, DG. "Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition." Biopolymers 94.4 (January 2010): 385-396. (Review) Full Text

Hamburger, JB, Hoertz, AJ, Lee, A, Senturia, RJ, McCafferty, DG, and Loll, PJ. "A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface." Proc Natl Acad Sci U S A 106.33 (August 18, 2009): 13759-13764. Full Text

Deshmukh, HS, Hamburger, JB, Ahn, SH, McCafferty, DG, Yang, SR, and Fowler, VG. "Critical role of NOD2 in regulating the immune response to Staphylococcus aureus." Infection and Immunity 77.4 (April 2009): 1376-1382. Full Text

Race, PR, Bentley, ML, Melvin, JA, Crow, A, Hughes, RK, Smith, WD, Sessions, RB, Kehoe, MA, McCafferty, DG, and Banfield, MJ. "Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism." The Journal of Biological Chemistry 284.11 (March 2009): 6924-6933. Full Text

Gaweska, H, Pozzi, MH, Schmidt, DMZ, McCafferty, DG, and Fitzpatrick, PF. "Use of pH and kinetic isotope effects to establish chemistry as rate-limiting in oxidation of a peptide substrate by LSD1." Biochemistry 48.23 (2009): 5440-5445. Full Text

Gooden, DM, Schmidt, DMZ, Pollock, JA, Kabadi, AM, and McCafferty, DG. "Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B." Bioorganic & Medicinal Chemistry Letters 18.10 (May 2008): 3047-3051. Full Text

Bentley, ML, Lamb, EC, and McCafferty, DG. "Mutagenesis studies of substrate recognition and catalysis in the sortase A transpeptidase from Staphylococcus aureus." The Journal of Biological Chemistry 283.21 (May 2008): 14762-14771. Full Text

Frankel, BA, Tong, Y, Bentley, ML, Fitzgerald, MC, and McCafferty, DG. "Mutational analysis of active site residues in the Staphylococcus aureus transpeptidase SrtA." Biochemistry 46.24 (June 2007): 7269-7278. Full Text