Faculty Profiles

Dewey G. McCafferty
Professor of Chemistry
Office: 
B120 Lsrc, Box 90346, 450 Research Drive, Dept. Chemistry, Durham, NC 27708-0346
Phone: 
(919) 660-1516
Fax: 
(919) 660-1605

Overview

Education:

Ph.D., University of North Carolina - Chapel Hill 1995

B.S., North Carolina State University 1990

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Hatstat, A. Katherine, and Dewey G. McCafferty. “Robust and facile purification of full-length, untagged human Nedd4 as a recombinant protein from Escherichia coli.Protein Expression and Purification, vol. 173, Sept. 2020, p. 105649. Epmc, doi:10.1016/j.pep.2020.105649. Full Text

Dudiak, Brianne M., et al. “Insights into the Autoproteolytic Processing and Catalytic Mechanism of the Chlamydia trachomatis Virulence-Associated Protease CPAF.Biochemistry, vol. 58, no. 33, Aug. 2019, pp. 3527–36. Pubmed, doi:10.1021/acs.biochem.9b00522. Full Text

Biniossek, Martin L., et al. “Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics.Molecular & Cellular Proteomics : Mcp, vol. 15, no. 7, July 2016, pp. 2515–24. Epmc, doi:10.1074/mcp.o115.056671. Full Text

Burg, Jonathan M., et al. “Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones.Biochemistry, vol. 55, no. 11, Mar. 2016, pp. 1652–62. Epmc, doi:10.1021/acs.biochem.5b01135. Full Text

Maksimchuk, Kenneth R., et al. “The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins.Plos One, vol. 11, no. 2, 2016, p. e0147233. Pubmed, doi:10.1371/journal.pone.0147233. Full Text

Burg, Jonathan M., et al. “A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity.Febs Letters, vol. 589, no. 18, Aug. 2015, pp. 2340–46. Epmc, doi:10.1016/j.febslet.2015.07.028. Full Text

Burg, Jonathan M., et al. “KDM1 class flavin-dependent protein lysine demethylases.Biopolymers, vol. 104, no. 4, July 2015, pp. 213–46. Epmc, doi:10.1002/bip.22643. Full Text

Snavely, Emily A., et al. “Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches.Pathog Dis, vol. 71, no. 3, Aug. 2014, pp. 336–51. Pubmed, doi:10.1111/2049-632X.12179. Full Text

McCafferty, D. G., and J. A. Melvin. Sortases. Vol. 2, Aug. 2013, pp. 2459–65. Scopus, doi:10.1016/B978-0-12-382219-2.00549-4. Full Text

Qi, Yizhi, et al. “Sortase-catalyzed initiator attachment enables high yield growth of a stealth polymer from the C terminus of a protein.Macromolecular Rapid Communications, vol. 34, no. 15, Aug. 2013, pp. 1256–60. Epmc, doi:10.1002/marc.201300460. Full Text

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