Faculty Profiles

Barbara R. Shaw
William T. Miller Professor Emeritus of Chemistry
Office: 
1105 French Family Science Ctr, Box 90346, Chemistry Department, Durham, NC 27708-0346
Phone: 
(919) 451-9197
Fax: 
(919) 660-1605

Overview

Education:

Ph.D., University of Washington 1973

M.S., University of Washington 1967

B.A., Bryn Mawr College 1965

Hall, Allison H. S., et al. “RNA interference using boranophosphate siRNAs: structure-activity relationships..” Nucleic Acids Res, vol. 32, no. 20, 2004, pp. 5991–6000. Pubmed, doi:10.1093/nar/gkh936. Full Text

Shaw, Barbara Ramsay, et al. “Reading, writing, and modulating genetic information with boranophosphate mimics of nucleotides, DNA, and RNA..” Annals of the New York Academy of Sciences, vol. 1002, Dec. 2003, pp. 12–29. Epmc, doi:10.1196/annals.1281.004. Full Text

Li, Ping, et al. “Synthesis of acyclothymidine triphosphate and alpha-P-boranotriphosphate and their substrate properties with retroviral reverse transcriptase..” Organic Letters, vol. 5, no. 14, July 2003, pp. 2401–03. Epmc, doi:10.1021/ol034538w. Full Text

Li, Ping, and Barbara Ramsay Shaw. “One-pot synthesis of an AZT boranophosphate conjugated with tyrosine: a potential prodrug candidate..” Nucleosides, Nucleotides & Nucleic Acids, vol. 22, no. 5–8, May 2003, pp. 699–701. Epmc, doi:10.1081/ncn-120022613. Full Text

Wang, Xin, et al. “RNase H activation by stereoregular boranophosphate oligonucleotide..” Nucleosides, Nucleotides & Nucleic Acids, vol. 22, no. 5–8, May 2003, pp. 1151–53. Epmc, doi:10.1081/ncn-120022823. Full Text

Dobrikov, Mikhail I., et al. “Incorporation of (alpha-P-borano)-2',3'-dideoxycytidine 5'-triphosphate into DNA by drug-resistant MMLV reverse transcriptase and Taq DNA polymerase..” Nucleosides, Nucleotides & Nucleic Acids, vol. 22, no. 5–8, May 2003, pp. 1651–55. Epmc, doi:10.1081/ncn-120023091. Full Text

Dobrikov, Mikhail I., et al. “Introduction of the alpha-P-borano-group into deoxynucleoside triphosphates increases their selectivity to HIV-1 reverse transcriptase relative to DNA polymerases..” Nucleosides, Nucleotides & Nucleic Acids, vol. 22, no. 3, Mar. 2003, pp. 275–82. Epmc, doi:10.1081/ncn-120021427. Full Text

Li, Ping, and Barbara Ramsay Shaw. “Synthesis of nucleoside 3',5'-cyclic boranophosphorothioate, a new type of cyclic nucleotide..” Chemical Communications (Cambridge, England), no. 23, Dec. 2002, pp. 2890–91. Epmc, doi:10.1039/b207350a. Full Text

Fisher, Anna Astriab, et al. “Evaluating the specificity of antisense oligonucleotide conjugates. A DNA array analysis..” The Journal of Biological Chemistry, vol. 277, no. 25, June 2002, pp. 22980–84. Epmc, doi:10.1074/jbc.m203347200. Full Text

Li, Ping, and Barbara Ramsay Shaw. “Synthesis of prodrug candidates: conjugates of amino acid with nucleoside boranophosphate..” Organic Letters, vol. 4, no. 12, June 2002, pp. 2009–12. Epmc, doi:10.1021/ol025832b. Full Text

Pages