Faculty Profiles

Ashutosh Chilkoti
Professor in the Department of Chemistry
1427 CIEMAS, Durham, NC 27708
(919) 660-5373
+1 919 660 5409



Ph.D., University of Washington 1991

Simon, JR, Carroll, NJ, Rubinstein, M, Chilkoti, A, and López, GP. "Programming molecular self-assembly of intrinsically disordered proteins containing sequences of low complexity." Nature Chemistry 9.6 (June 2017): 509-515. Full Text

Han, W, Chilkoti, A, and López, GP. "Self-assembled hybrid elastin-like polypeptide/silica nanoparticles enable triggered drug release." Nanoscale 9.18 (May 2017): 6178-6186. Full Text

Weinberger, A, Walter, V, MacEwan, SR, Schmatko, T, Muller, P, Schroder, AP, Chilkoti, A, and Marques, CM. "Cargo self-assembly rescues affinity of cell-penetrating peptides to lipid membranes." Scientific Reports 7 (March 6, 2017). Full Text

Bhattacharyya, J, Weitzhandler, I, Ho, SB, McDaniel, JR, Li, X, Tang, L, Liu, J, Dewhirst, M, and Chilkoti, A. "Encapsulating a Hydrophilic Chemotherapeutic into Rod-like Nanoparticles of a Genetically Encoded Asymmetric Triblock Polypeptide Improves its Efficacy." Advanced Functional Materials 27.12 (March 2017). Full Text

Widder, K, MacEwan, SR, Garanger, E, Núñez, V, Lecommandoux, S, Chilkoti, A, and Hinderberger, D. "Characterisation of hydration and nanophase separation during the temperature response in hydrophobic/hydrophilic elastin-like polypeptide (ELP) diblock copolymers." Soft matter 13.9 (March 2017): 1816-1822. Full Text

Ozer, I, and Chilkoti, A. "Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins." Bioconjugate Chemistry 28.3 (March 2017): 713-723. (Review) Full Text

Gonzalez, MA, Simon, JR, Ghoorchian, A, Scholl, Z, Lin, S, Rubinstein, M, Marszalek, P, Chilkoti, A, López, GP, and Zhao, X. "Strong, Tough, Stretchable, and Self-Adhesive Hydrogels from Intrinsically Unstructured Proteins." Advanced Materials (Deerfield Beach, Fla.) 29.10 (March 2017). Full Text

MacEwan, SR, Weitzhandler, I, Hoffmann, I, Genzer, J, Gradzielski, M, and Chilkoti, A. "Phase Behavior and Self-Assembly of Perfectly Sequence-Defined and Monodisperse Multiblock Copolypeptides." Biomacromolecules 18.2 (February 2017): 599-609. Full Text

Joh, DY, McGuire, F, Abedini-Nassab, R, Andrews, JB, Achar, RK, Zimmers, Z, Mozhdehi, D, Blair, R, Albarghouthi, F, Oles, W, Richter, J, Fontes, CM, Hucknall, AM, Yellen, BB, Franklin, AD, and Chilkoti, A. "Poly(oligo(ethylene glycol) methyl ether methacrylate) Brushes on High-κ Metal Oxide Dielectric Surfaces for Bioelectrical Environments." ACS applied materials & interfaces 9.6 (February 2017): 5522-5529. Full Text

Wang, J, MacEwan, SR, and Chilkoti, A. "Quantitative Mapping of the Spatial Distribution of Nanoparticles in Endo-Lysosomes by Local pH." Nano Letters 17.2 (February 2017): 1226-1232. Full Text


Liu, W, Dreher, MR, Chow, DC, Zalutsky, MR, and Chilkoti, A. "Tracking the in vivo fate of recombinant polypeptides by isotopic labeling." 3rd International Nanomedicine and Drug Delivery Symposium. September 26, 2005 - September 27, 2005. Baltimore, MD.: ELSEVIER SCIENCE BV, August 28, 2006. Full Text

Wong, JY, Plant, AL, Schmidt, CE, Shea, L, Coury, AJ, Chen, CS, Barron, AE, Klok, HA, Deming, TJ, Saltzman, WM, Chilkoti, A, Luo, D, and Uhrich, K. "Materials Research Society Symposium Proceedings: Preface." December 1, 2004.

Valiaev, A, Lim, DW, Clark, R, Chilkoti, A, and Zauscher, S. "Mechanics of stimulus-responsive elastin-like polypeptides studied by force spectroscopy." August 22, 2004.

Prohaska, S, Dreher, M, Dewhirst, MW, Chilkoti, A, Pries, AR, Westerhoff, M, and Cornelissen, AJM. "3-D reconstruction of tumor vascular networks." 2004.