Faculty Profiles

Ashutosh Chilkoti
Ashutosh Chilkoti
Professor in the Department of Chemistry
Office: 
1427 CIEMAS, Durham, NC 27708
Phone: 
(919) 660-5373
Fax: 
+1 919 660 5409
http://chilkotilab.pratt.duke.edu
Google Scholar
Research Interests: 

Ashutosh Chilkoti is the Alan L. Kaganov Professor of Biomedical Engineering and Chair of the Department of Biomedical Engineering at Duke University.

My research in biomolecular engineering and biointerface science focuses on the development of new molecular tools and technologies that borrow from molecular biology, protein engineering, polymer chemistry and surface science that we then exploit for the development of applications that span the range from bioseparations, plasmonic biosensors, low-cost clinical diagnostics, and drug delivery.

Overview

Education:

Ph.D., University of Washington 1991

Wang, Jing, et al. “Heuristics for the Optimal Presentation of Bioactive Peptides on Polypeptide Micelles..” Nano Letters, vol. 19, no. 11, Nov. 2019, pp. 7977–87. Epmc, doi:10.1021/acs.nanolett.9b03141. Full Text

Garcia Quiroz, Felipe, et al. “Intrinsically disordered proteins access a range of hysteretic phase separation behaviors..” Science Advances, vol. 5, no. 10, Oct. 2019. Epmc, doi:10.1126/sciadv.aax5177. Full Text

Dai, Zhuojun, et al. “Versatile biomanufacturing through stimulus-responsive cell-material feedback..” Nature Chemical Biology, vol. 15, no. 10, Oct. 2019, pp. 1017–24. Epmc, doi:10.1038/s41589-019-0357-8. Full Text

Willems, Lione, et al. “Nature of Amorphous Hydrophilic Block Affects Self-Assembly of an Artificial Viral Coat Polypeptide..” Biomacromolecules, vol. 20, no. 10, Oct. 2019, pp. 3641–47. Epmc, doi:10.1021/acs.biomac.9b00512. Full Text

Dzuricky, Michael, et al. “Avidity and Cell Uptake of Integrin-Targeting Polypeptide Micelles is Strongly Shape-Dependent..” Nano Letters, vol. 19, no. 9, Sept. 2019, pp. 6124–32. Epmc, doi:10.1021/acs.nanolett.9b02095. Full Text

Manzari, Mandana T., et al. “Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models..” Sci Adv, vol. 5, no. 9, Sept. 2019. Pubmed, doi:10.1126/sciadv.aaw9162. Full Text

Simon, Joseph R., et al. “Engineered Ribonucleoprotein Granules Inhibit Translation in Protocells..” Molecular Cell, vol. 75, no. 1, July 2019, pp. 66-75.e5. Epmc, doi:10.1016/j.molcel.2019.05.010. Full Text

Varanko, Anastasia K., and Ashutosh Chilkoti. “Molecular and Materials Engineering for Delivery of Peptide Drugs to Treat Type 2 Diabetes..” Advanced Healthcare Materials, vol. 8, no. 12, June 2019. Epmc, doi:10.1002/adhm.201801509. Full Text

Willems, Lione, et al. “Inducible Fibril Formation of Silk-Elastin Diblocks..” Acs Omega, vol. 4, no. 5, May 2019, pp. 9135–43. Epmc, doi:10.1021/acsomega.9b01025. Full Text

Joh, Daniel Y., et al. “Architectural Modification of Conformal PEG-Bottlebrush Coatings Minimizes Anti-PEG Antigenicity While Preserving Stealth Properties..” Adv Healthc Mater, vol. 8, no. 8, Apr. 2019. Pubmed, doi:10.1002/adhm.201801177. Full Text

Pages

Deshpande, Sonal, et al. Enzymatic synthesis and modification of high molecular weight DNA using terminal deoxynucleotidyl transferase.. Vol. 627, 2019, pp. 163–88. Epmc, doi:10.1016/bs.mie.2019.07.044. Full Text

Bhattacharyya, J., et al. “Elastin-Like Polypeptides: Bio-Inspired Smart Polymers for Protein Purification, Drug Delivery and Tissue Engineering.” Biomaterials from Nature for Advanced Devices and Therapies, 2016, pp. 106–26. Scopus, doi:10.1002/9781119126218.ch7. Full Text

Hill, R. T., and A. Chilkoti. “Surface Patterning.” Biomaterials Science: An Introduction to Materials: Third Edition, 2013, pp. 276–301. Scopus, doi:10.1016/B978-0-08-087780-8.00028-0. Full Text

Nusz, G., and A. Chilkoti. “Individual plasmonic nanostructures as label free biosensors.” Nanoplasmonic Sensors, 2012, pp. 105–26. Scopus, doi:10.1007/978-1-4614-3933-2_5. Full Text

Bhattacharyya, Jayanta, and Ashutosh Chilkoti. “Abstract 4481: Genetically encoded chimeric polypeptide nanoparticles for gemcitabine delivery to solid tumors.” Cancer Chemistry, American Association for Cancer Research, 2014. Crossref, doi:10.1158/1538-7445.am2014-4481. Full Text

Liu, Wenge, et al. “Abstract 4583: In situ photocontrolled intratumoral depot for combined photodynamic therapy and brachytherapy for solid tumor.” Experimental and Molecular Therapeutics, American Association for Cancer Research, 2014. Crossref, doi:10.1158/1538-7445.am2014-4583. Full Text

Chilkoti, Ashutosh. “Surface initiated polymerization and its applications in medicine.” Abstracts of Papers of the American Chemical Society, vol. 248, AMER CHEMICAL SOC, 2014.

Chilkoti, Ashutosh. “Genetically encoded polypeptide nanoparticles for delivery of drugs.” Abstracts of Papers of the American Chemical Society, vol. 247, AMER CHEMICAL SOC, 2014.

Quiroz, F. G., and A. Chilkoti. “The language of protein polymers.” Acs Symposium Series, vol. 1170, 2014, pp. 15–33. Scopus, doi:10.1021/bk-2014-1170.ch002. Full Text

Chilkoti, Ashutosh. “Genetically engineered polypeptide conjugates and fusions for drug delivery.” Abstracts of Papers of the American Chemical Society, vol. 246, AMER CHEMICAL SOC, 2013.

Tang, Lei, et al. “Enzyme catalyzed polymerization of DNA amphiphiles that self-assemble into star-like micelles.” Abstracts of Papers of the American Chemical Society, vol. 246, AMER CHEMICAL SOC, 2013.

Chilkoti, Ashutosh. “Syntax of "smart" peptide polymers governs their function.” Abstracts of Papers of the American Chemical Society, vol. 246, AMER CHEMICAL SOC, 2013.

Garanger, Elisabeth, et al. “Elastin-based amphiphilic copolymers as precision building blocks for controlled self-assembly.” Abstracts of Papers of the American Chemical Society, vol. 246, AMER CHEMICAL SOC, 2013.

Weinberger, A., et al. “Interactions of elastin-like polypeptides with model membranes on GUVs.” European Biophysics Journal With Biophysics Letters, vol. 42, SPRINGER, 2013, pp. S158–S158.

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