Faculty Profiles

Amanda Hargrove
Associate Professor of Chemistry
Office: 
3219 French Science Center, Box 90346, Durham, NC 27708
Phone: 
(919) 660-1522
Fax: 
(919) 660-1605

Overview

Education:

NIH Postdoctoral Fellow, Chemistry, California Institute of Technology 2010 - 2013

Ph.D., University of Texas, Austin 2010

B.S., Trinity University 2004

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Donlic, Anita, et al. “Regulation of MALAT1 triple helix stability and in vitro degradation by diphenylfurans.Nucleic Acids Research, July 2020. Epmc, doi:10.1093/nar/gkaa585. Full Text

Umuhire Juru, Aline, et al. “Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry.Chemical Communications (Cambridge, England), vol. 56, no. 24, Mar. 2020, pp. 3555–58. Epmc, doi:10.1039/d0cc00266f. Full Text

Ganser, Laura R., et al. “Demonstration that Small Molecules can Bind and Stabilize Low-abundance Short-lived RNA Excited Conformational States.J Mol Biol, vol. 432, no. 4, Feb. 2020, pp. 1297–304. Pubmed, doi:10.1016/j.jmb.2019.12.009. Full Text

Hargrove, Amanda E. “The next 20 years of Medicinal Research Reviews.Medicinal Research Reviews, Dec. 2019. Epmc, doi:10.1002/med.21656. Full Text

Morgan, Brittany S., et al. “R-BIND: An Interactive Database for Exploring and Developing RNA-Targeted Chemical Probes.Acs Chemical Biology, vol. 14, no. 12, Dec. 2019, pp. 2691–700. Epmc, doi:10.1021/acschembio.9b00631. Full Text

Patwardhan, Neeraj N., et al. “Driving factors in amiloride recognition of HIV RNA targets.Organic & Biomolecular Chemistry, vol. 17, no. 42, Oct. 2019, pp. 9313–20. Epmc, doi:10.1039/c9ob01702j. Full Text

Wicks, Sarah L., and Amanda E. Hargrove. “Fluorescent indicator displacement assays to identify and characterize small molecule interactions with RNA.Methods (San Diego, Calif.), vol. 167, Sept. 2019, pp. 3–14. Epmc, doi:10.1016/j.ymeth.2019.04.018. Full Text

Umuhire Juru, Aline, et al. “Understanding the Contributions of Conformational Changes, Thermodynamics, and Kinetics of RNA-Small Molecule Interactions.Acs Chemical Biology, vol. 14, no. 5, May 2019, pp. 824–38. Epmc, doi:10.1021/acschembio.8b00945. Full Text

Eubanks, Christopher S., et al. “Visualizing RNA Conformational Changes via Pattern Recognition of RNA by Small Molecules.Journal of the American Chemical Society, vol. 141, no. 14, Apr. 2019, pp. 5692–98. Epmc, doi:10.1021/jacs.8b09665. Full Text

Donlic, Anita, et al. “Corrigendum: Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold.Angewandte Chemie (International Ed. in English), vol. 58, no. 17, Apr. 2019, p. 5482. Epmc, doi:10.1002/anie.201900875. Full Text

Pages

Hargrove, A. E. Preface. Vol. 623, 2019, pp. xv–xvii. Scopus, doi:10.1016/S0076-6879(19)30266-6. Full Text

Hargrove, Amanda E. Preface. Vol. 623, 2019, pp. xv–xvii. Pubmed, doi:10.1016/S0076-6879(19)30266-6. Full Text

Hargrove, Amanda E. “RNA Recognition.” RNA RECOGNITION, edited by A. E. Hargrove, vol. 623, ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD, 2019, pp. XV–XVII.

Padroni, Giacomo, et al. Differentiation and classification of RNA motifs using small molecule-based pattern recognition. Vol. 623, 2019, pp. 101–30. Epmc, doi:10.1016/bs.mie.2019.05.022. Full Text