Faculty Profiles

Amanda Hargrove
Associate Professor of Chemistry
3219 French Science Center, Box 90346, Durham, NC 27708
(919) 660-1522
(919) 660-1605



NIH Postdoctoral Fellow, Chemistry, California Institute of Technology 2010 - 2013

Ph.D., University of Texas, Austin 2010

B.S., Trinity University 2004

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Zafferani, Martina, et al. “Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures.Biorxiv, Dec. 2020. Pubmed, doi:10.1101/2020.12.05.409821. Full Text

Hargrove, Amanda E. “Small molecule-RNA targeting: starting with the fundamentals.Chemical Communications (Cambridge, England), vol. 56, no. 94, Nov. 2020, pp. 14744–56. Epmc, doi:10.1039/d0cc06796b. Full Text

Davila-Calderon, Jesse, et al. “IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex.Nature Communications, vol. 11, no. 1, Sept. 2020, p. 4775. Epmc, doi:10.1038/s41467-020-18594-3. Full Text

Donlic, Anita, et al. “Regulation of MALAT1 triple helix stability and in vitro degradation by diphenylfurans.Nucleic Acids Research, vol. 48, no. 14, Aug. 2020, pp. 7653–64. Epmc, doi:10.1093/nar/gkaa585. Full Text

Padroni, G., et al. “Systematic analysis of the interactions driving small molecule-RNA recognition.” Rsc Medicinal Chemistry, vol. 11, no. 7, July 2020, pp. 802–13. Scopus, doi:10.1039/d0md00167h. Full Text

Umuhire Juru, Aline, et al. “Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry.Chemical Communications (Cambridge, England), vol. 56, no. 24, Mar. 2020, pp. 3555–58. Epmc, doi:10.1039/d0cc00266f. Full Text

Ganser, Laura R., et al. “Demonstration that Small Molecules can Bind and Stabilize Low-abundance Short-lived RNA Excited Conformational States.J Mol Biol, vol. 432, no. 4, Feb. 2020, pp. 1297–304. Pubmed, doi:10.1016/j.jmb.2019.12.009. Full Text

Hargrove, Amanda E. “The next 20 years of Medicinal Research Reviews.Medicinal Research Reviews, vol. 40, no. 1, Jan. 2020, pp. 7–8. Epmc, doi:10.1002/med.21656. Full Text

Morgan, Brittany S., et al. “R-BIND: An Interactive Database for Exploring and Developing RNA-Targeted Chemical Probes.Acs Chemical Biology, vol. 14, no. 12, Dec. 2019, pp. 2691–700. Epmc, doi:10.1021/acschembio.9b00631. Full Text

Patwardhan, Neeraj N., et al. “Driving factors in amiloride recognition of HIV RNA targets.Organic & Biomolecular Chemistry, vol. 17, no. 42, Oct. 2019, pp. 9313–20. Epmc, doi:10.1039/c9ob01702j. Full Text


Hargrove, A. E. Preface. Vol. 623, 2019, pp. xv–xvii. Scopus, doi:10.1016/S0076-6879(19)30266-6. Full Text

Padroni, Giacomo, et al. Differentiation and classification of RNA motifs using small molecule-based pattern recognition. Vol. 623, 2019, pp. 101–30. Epmc, doi:10.1016/bs.mie.2019.05.022. Full Text

Hargrove, Amanda E. Preface. Vol. 623, 2019, pp. xv–xvii. Pubmed, doi:10.1016/S0076-6879(19)30266-6. Full Text

Hargrove, Amanda E. “RNA Recognition.” RNA RECOGNITION, edited by A. E. Hargrove, vol. 623, ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD, 2019, pp. XV–XVII.

Umuhire Juru, Aline, and Amanda E. Hargrove. “Frameworks for targeting RNA with small molecules.The Journal of Biological Chemistry, 2020. Epmc, doi:10.1074/jbc.rev120.015203. Full Text