Faculty Profiles

Amanda Hargrove
Amanda Hargrove
Associate Professor of Chemistry
Office: 
3219 French Science Center, Box 90346, Durham, NC 27708
Phone: 
(919) 660-1522
Fax: 
(919) 660-1605
amanda.hargrove@duke.edu
Hargrove Research Group
Research Interests: 

The Hargrove lab harnesses the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs). The discovery of these fascinating biomolecules has caused a paradigm shift in molecular biology and speculation as to their role as the master drivers of diseases such as cancer. At the same time very little is known about their structure and function, leading some to call the field a veritable “wild West.” Small molecules are the perfect tools for such exploration, and the Hargrove lab works at the interface of chemistry and biology, employing methods ranging from RNA-targeted small molecule synthesis and array-based pattern recognition to studies of the molecular and cellular biology of nucleic acids. Collaborations with the Department of Biology as well as colleagues in the School of Medicine ensure that these tools are applied to the most important unsolved problems in the fundamental biology and disease-related actions of long noncoding RNAs.

Overview

Education:

NIH Postdoctoral Fellow, Chemistry, California Institute of Technology 2010 - 2013

Ph.D., University of Texas, Austin 2010

B.S., Trinity University 2004

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Zafferani, Martina, et al. “Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures.” Biorxiv, Dec. 2020. Pubmed, doi:10.1101/2020.12.05.409821. Full Text

Hargrove, Amanda E. “Small molecule-RNA targeting: starting with the fundamentals.” Chemical Communications (Cambridge, England), vol. 56, no. 94, Nov. 2020, pp. 14744–56. Epmc, doi:10.1039/d0cc06796b. Full Text

Davila-Calderon, Jesse, et al. “IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex.” Nature Communications, vol. 11, no. 1, Sept. 2020, p. 4775. Epmc, doi:10.1038/s41467-020-18594-3. Full Text

Donlic, Anita, et al. “Regulation of MALAT1 triple helix stability and in vitro degradation by diphenylfurans.” Nucleic Acids Research, vol. 48, no. 14, Aug. 2020, pp. 7653–64. Epmc, doi:10.1093/nar/gkaa585. Full Text

Padroni, G., et al. “Systematic analysis of the interactions driving small molecule-RNA recognition.” Rsc Medicinal Chemistry, vol. 11, no. 7, July 2020, pp. 802–13. Scopus, doi:10.1039/d0md00167h. Full Text

Umuhire Juru, Aline, et al. “Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry.” Chemical Communications (Cambridge, England), vol. 56, no. 24, Mar. 2020, pp. 3555–58. Epmc, doi:10.1039/d0cc00266f. Full Text

Ganser, Laura R., et al. “Demonstration that Small Molecules can Bind and Stabilize Low-abundance Short-lived RNA Excited Conformational States.” J Mol Biol, vol. 432, no. 4, Feb. 2020, pp. 1297–304. Pubmed, doi:10.1016/j.jmb.2019.12.009. Full Text

Hargrove, Amanda E. “The next 20 years of Medicinal Research Reviews.” Medicinal Research Reviews, vol. 40, no. 1, Jan. 2020, pp. 7–8. Epmc, doi:10.1002/med.21656. Full Text

Morgan, Brittany S., et al. “R-BIND: An Interactive Database for Exploring and Developing RNA-Targeted Chemical Probes.” Acs Chemical Biology, vol. 14, no. 12, Dec. 2019, pp. 2691–700. Epmc, doi:10.1021/acschembio.9b00631. Full Text

Patwardhan, Neeraj N., et al. “Driving factors in amiloride recognition of HIV RNA targets.” Organic & Biomolecular Chemistry, vol. 17, no. 42, Oct. 2019, pp. 9313–20. Epmc, doi:10.1039/c9ob01702j. Full Text

Pages

Hargrove, A. E. Preface. Vol. 623, 2019, pp. xv–xvii. Scopus, doi:10.1016/S0076-6879(19)30266-6. Full Text

Padroni, Giacomo, et al. Differentiation and classification of RNA motifs using small molecule-based pattern recognition. Vol. 623, 2019, pp. 101–30. Epmc, doi:10.1016/bs.mie.2019.05.022. Full Text

Hargrove, Amanda E. Preface. Vol. 623, 2019, pp. xv–xvii. Pubmed, doi:10.1016/S0076-6879(19)30266-6. Full Text

Hargrove, Amanda E. “RNA Recognition.” RNA RECOGNITION, edited by A. E. Hargrove, vol. 623, ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD, 2019, pp. XV–XVII.

Umuhire Juru, Aline, and Amanda E. Hargrove. “Frameworks for targeting RNA with small molecules.” The Journal of Biological Chemistry, 2020. Epmc, doi:10.1074/jbc.rev120.015203. Full Text