Faculty Profiles

Amanda Hargrove
Amanda Hargrove
Associate Professor of Chemistry
Office: 
3219 French Science Center, Box 90346, Durham, NC 27708
Phone: 
(919) 660-1522
Fax: 
(919) 660-1605
amanda.hargrove@duke.edu
Hargrove Research Group
Research Interests: 

The Hargrove lab harnesses the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs). The discovery of these fascinating biomolecules has caused a paradigm shift in molecular biology and speculation as to their role as the master drivers of diseases such as cancer. At the same time very little is known about their structure and function, leading some to call the field a veritable “wild West.” Small molecules are the perfect tools for such exploration, and the Hargrove lab works at the interface of chemistry and biology, employing methods ranging from RNA-targeted small molecule synthesis and array-based pattern recognition to studies of the molecular and cellular biology of nucleic acids. Collaborations with the Department of Biology as well as colleagues in the School of Medicine ensure that these tools are applied to the most important unsolved problems in the fundamental biology and disease-related actions of long noncoding RNAs.

Overview

Education:

NIH Postdoctoral Fellow, Chemistry, California Institute of Technology 2010 - 2013

Ph.D., University of Texas, Austin 2010

B.S., Trinity University 2004

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Raskatov, Jevgenij A., et al. “Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.” Journal of the American Chemical Society, vol. 134, no. 18, May 2012, pp. 7995–99. Epmc, doi:10.1021/ja302588v. Full Text

Hargrove, Amanda E., et al. “Artificial receptors for the recognition of phosphorylated molecules.” Chemical Reviews, vol. 111, no. 11, Nov. 2011, pp. 6603–782. Epmc, doi:10.1021/cr100242s. Full Text

Hargrove, Amanda E., et al. “Chemical functionalization of oligodeoxynucleotides with multiple boronic acids for the polyvalent binding of saccharides.” Bioconjugate Chemistry, vol. 22, no. 3, Mar. 2011, pp. 388–96. Epmc, doi:10.1021/bc100376x. Full Text

Hargrove, Amanda E., et al. “Boronic acid porphyrin receptor for ginsenoside sensing.” Organic Letters, vol. 12, no. 21, Nov. 2010, pp. 4804–07. Epmc, doi:10.1021/ol1019647. Full Text

Hargrove, A. E., et al. “Algorithms for the determination of binding constants and enantiomeric excess in complex host: Guest equilibria using optical measurements.” New Journal of Chemistry, vol. 34, no. 2, Jan. 2010, pp. 348–54. Scopus, doi:10.1039/b9nj00498j. Full Text

Collins, B. E., et al. “Probing intramolecular B-N interactions in ortho-aminomethyl arylboronic acids.” Journal of Organic Chemistry, vol. 74, no. 11, June 2009, pp. 4055–60. Scopus, doi:10.1021/jo900187a. Full Text

Pikulski, Michael, et al. “Sequencing and characterization of oligosaccharides using infrared multiphoton dissociation and boronic acid derivatization in a quadrupole ion trap.” Journal of the American Society for Mass Spectrometry, vol. 18, no. 12, Dec. 2007, pp. 2094–106. Epmc, doi:10.1016/j.jasms.2007.09.005. Full Text

Spence, J. D., et al. “Porphyrenediynes: synthesis and cyclization of meso-enediynylporphyrins.” Tetrahedron Letters, vol. 48, no. 4, Jan. 2007, pp. 725–28. Scopus, doi:10.1016/j.tetlet.2006.10.164. Full Text

Sessler, J. L., et al. “Chemical and electrochemical oxidation of N-alkyl cyclo[n]-pyrroles.” Journal of Porphyrins and Phthalocyanines, vol. 10, no. 12, Jan. 2006, pp. 1329–36. Scopus, doi:10.1142/S1088424606000703. Full Text

Davila-Calderon, Jesse, et al. Small Molecule Targeting IRES Domain Inhibits Enterovirus 71 Replication via an Allosteric Mechanism that Stabilizes a Ternary Complex. Cold Spring Harbor Laboratory. Crossref, doi:10.1101/2020.03.10.981167. Full Text

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