Faculty Profiles

Amanda Hargrove
Associate Professor of Chemistry
Office: 
3219 French Science Center, Box 90346, Durham, NC 27708
Phone: 
(919) 660-1522
Fax: 
(919) 660-1605

Overview

Education:

NIH Postdoctoral Fellow, Chemistry, California Institute of Technology 2010 - 2013

Ph.D., University of Texas, Austin 2010

B.S., Trinity University 2004

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Burg, Jonathan M., et al. “KDM1 class flavin-dependent protein lysine demethylases.Biopolymers, vol. 104, no. 4, July 2015, pp. 213–46. Epmc, doi:10.1002/bip.22643. Full Text

Morgan, B. S., and A. E. Hargrove. “Synthetic receptors for oligonucleotides and nucleic acids.” Monographs in Supramolecular Chemistry, vol. 2015-January, no. 14, Jan. 2015, pp. 253–325.

Hargrove, Amanda E., et al. “Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide.Plos One, vol. 10, no. 11, Jan. 2015, p. e0143161. Epmc, doi:10.1371/journal.pone.0143161. Full Text

Nickols, Nicholas G., et al. “Activity of a Py-Im polyamide targeted to the estrogen response element.Molecular Cancer Therapeutics, vol. 12, no. 5, May 2013, pp. 675–84. Epmc, doi:10.1158/1535-7163.mct-12-1040. Full Text

Raskatov, Jevgenij A., et al. “Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide.Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 40, Oct. 2012, pp. 16041–45. Epmc, doi:10.1073/pnas.1214267109. Full Text

Hargrove, Amanda E., et al. “Characterization and solubilization of pyrrole-imidazole polyamide aggregates.Journal of Medicinal Chemistry, vol. 55, no. 11, June 2012, pp. 5425–32. Epmc, doi:10.1021/jm300380a. Full Text

Raskatov, Jevgenij A., et al. “Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear.Journal of the American Chemical Society, vol. 134, no. 18, May 2012, pp. 7995–99. Epmc, doi:10.1021/ja302588v. Full Text

Hargrove, Amanda E., et al. “Artificial receptors for the recognition of phosphorylated molecules.Chemical Reviews, vol. 111, no. 11, Nov. 2011, pp. 6603–782. Epmc, doi:10.1021/cr100242s. Full Text

Hargrove, Amanda E., et al. “Chemical functionalization of oligodeoxynucleotides with multiple boronic acids for the polyvalent binding of saccharides.Bioconjugate Chemistry, vol. 22, no. 3, Mar. 2011, pp. 388–96. Epmc, doi:10.1021/bc100376x. Full Text

Hargrove, Amanda E., et al. “Boronic acid porphyrin receptor for ginsenoside sensing.Organic Letters, vol. 12, no. 21, Nov. 2010, pp. 4804–07. Epmc, doi:10.1021/ol1019647. Full Text

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