Faculty Profiles

Amanda Hargrove
Associate Professor of Chemistry
Office: 
3219 French Science Center, Box 90346, Durham, NC 27708
Phone: 
(919) 660-1522
Fax: 
(919) 660-1605

Overview

Education:

NIH Postdoctoral Fellow, Chemistry, California Institute of Technology 2010 - 2013

Ph.D., University of Texas, Austin 2010

B.S., Trinity University 2004

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Patwardhan, Neeraj N., et al. “Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA.Organic & Biomolecular Chemistry, vol. 17, no. 7, Feb. 2019, pp. 1778–86. Epmc, doi:10.1039/c8ob02467g. Full Text

Eubanks, Christopher S., and Amanda E. Hargrove. “RNA Structural Differentiation: Opportunities with Pattern Recognition.Biochemistry, vol. 58, no. 4, Jan. 2019, pp. 199–213. Epmc, doi:10.1021/acs.biochem.8b01090. Full Text

Donlic, Anita, et al. “Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold.Angewandte Chemie (International Ed. in English), vol. 57, no. 40, Oct. 2018, pp. 13242–47. Epmc, doi:10.1002/anie.201808823. Full Text

Morgan, Brittany S., et al. “Insights into the development of chemical probes for RNA.Nucleic Acids Research, vol. 46, no. 16, Sept. 2018, pp. 8025–37. Epmc, doi:10.1093/nar/gky718. Full Text

Donlic, Anita, and Amanda E. Hargrove. “Targeting RNA in mammalian systems with small molecules.Wiley Interdisciplinary Reviews. Rna, vol. 9, no. 4, July 2018, p. e1477. Epmc, doi:10.1002/wrna.1477. Full Text

Eubanks, Christopher S., and Amanda E. Hargrove. “Sensing the impact of environment on small molecule differentiation of RNA sequences.Chemical Communications (Cambridge, England), vol. 53, no. 100, Dec. 2017, pp. 13363–66. Epmc, doi:10.1039/c7cc07157d. Full Text

Morgan, Brittany S., et al. “Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands.Angewandte Chemie (International Ed. in English), vol. 56, no. 43, Oct. 2017, pp. 13498–502. Epmc, doi:10.1002/anie.201707641. Full Text

Patwardhan, Neeraj N., et al. “Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR.Medchemcomm, vol. 8, no. 5, May 2017, pp. 1022–36. Pubmed, doi:10.1039/C6MD00729E. Full Text

Eubanks, Christopher S., et al. “Small Molecule-Based Pattern Recognition To Classify RNA Structure.Journal of the American Chemical Society, vol. 139, no. 1, Jan. 2017, pp. 409–16. Epmc, doi:10.1021/jacs.6b11087. Full Text

McFadden, Emily J., and Amanda E. Hargrove. “Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin.Biochemistry, vol. 55, no. 11, Mar. 2016, pp. 1615–30. Epmc, doi:10.1021/acs.biochem.5b01141. Full Text

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