Faculty Profiles

Amanda Hargrove
Assistant Professor of Chemistry
3219 French Science Center, Box 90346, Durham, NC 27708
(919) 660-1522
(919) 660-1605



NIH Postdoctoral Fellow, Chemistry, California Institute of Technology 2010 - 2013

Ph.D., University of Texas at Austin 2010

B.S., Trinity University 2004

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Donlic, A, Morgan, BS, Xu, JL, Liu, A, Roble, C, and Hargrove, AE. "Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold." Angewandte Chemie (International Ed. in English) 57.40 (October 2018): 13242-13247. Full Text

Morgan, BS, Forte, JE, and Hargrove, AE. "Insights into the development of chemical probes for RNA." Nucleic Acids Research 46.16 (September 2018): 8025-8037. Full Text

Donlic, A, and Hargrove, AE. "Targeting RNA in mammalian systems with small molecules." Wiley Interdisciplinary Reviews. Rna 9.4 (July 2018): e1477-null. (Review) Full Text

Eubanks, CS, and Hargrove, AE. "Sensing the impact of environment on small molecule differentiation of RNA sequences." Chemical Communications (Cambridge, England) 53.100 (December 2017): 13363-13366. Full Text

Morgan, BS, Forte, JE, Culver, RN, Zhang, Y, and Hargrove, AE. "Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands." Angewandte Chemie (International Ed. in English) 56.43 (October 2017): 13498-13502. Full Text

Patwardhan, NN, Ganser, LR, Kapral, GJ, Eubanks, CS, Lee, J, Sathyamoorthy, B, Al-Hashimi, HM, and Hargrove, AE. "Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR." Medchemcomm 8.5 (May 2017): 1022-1036. Full Text

Eubanks, CS, Forte, JE, Kapral, GJ, and Hargrove, AE. "Small Molecule-Based Pattern Recognition To Classify RNA Structure." Journal of the American Chemical Society 139.1 (January 2017): 409-416. Full Text

McFadden, EJ, and Hargrove, AE. "Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin." Biochemistry 55.11 (March 2016): 1615-1630. (Review) Full Text

Burg, JM, Link, JE, Morgan, BS, Heller, FJ, Hargrove, AE, and McCafferty, DG. "KDM1 class flavin-dependent protein lysine demethylases." Biopolymers 104.4 (July 2015): 213-246. (Review) Full Text

Hargrove, AE, Martinez, TF, Hare, AA, Kurmis, AA, Phillips, JW, Sud, S, Pienta, KJ, and Dervan, PB. "Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide." PloS one 10.11 (January 2015): e0143161-. Full Text