Faculty Profiles

Amanda Hargrove
Associate Professor of Chemistry
3219 French Science Center, Box 90346, Durham, NC 27708
(919) 660-1522
(919) 660-1605



NIH Postdoctoral Fellow, Chemistry, California Institute of Technology 2010 - 2013

Ph.D., University of Texas, Austin 2010

B.S., Trinity University 2004

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Davila-Calderon, Jesse, et al. “IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex.Nature Communications, vol. 11, no. 1, Sept. 2020, p. 4775. Epmc, doi:10.1038/s41467-020-18594-3. Full Text

Donlic, Anita, et al. “Regulation of MALAT1 triple helix stability and in vitro degradation by diphenylfurans.Nucleic Acids Research, vol. 48, no. 14, Aug. 2020, pp. 7653–64. Epmc, doi:10.1093/nar/gkaa585. Full Text

Padroni, G., et al. “Systematic analysis of the interactions driving small molecule-RNA recognition.” Rsc Medicinal Chemistry, vol. 11, no. 7, July 2020, pp. 802–13. Scopus, doi:10.1039/d0md00167h. Full Text

Umuhire Juru, Aline, et al. “Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry.Chemical Communications (Cambridge, England), vol. 56, no. 24, Mar. 2020, pp. 3555–58. Epmc, doi:10.1039/d0cc00266f. Full Text

Ganser, Laura R., et al. “Demonstration that Small Molecules can Bind and Stabilize Low-abundance Short-lived RNA Excited Conformational States.J Mol Biol, vol. 432, no. 4, Feb. 2020, pp. 1297–304. Pubmed, doi:10.1016/j.jmb.2019.12.009. Full Text

Hargrove, Amanda E. “The next 20 years of Medicinal Research Reviews.Medicinal Research Reviews, vol. 40, no. 1, Jan. 2020, pp. 7–8. Epmc, doi:10.1002/med.21656. Full Text

Morgan, Brittany S., et al. “R-BIND: An Interactive Database for Exploring and Developing RNA-Targeted Chemical Probes.Acs Chemical Biology, vol. 14, no. 12, Dec. 2019, pp. 2691–700. Epmc, doi:10.1021/acschembio.9b00631. Full Text

Patwardhan, Neeraj N., et al. “Driving factors in amiloride recognition of HIV RNA targets.Organic & Biomolecular Chemistry, vol. 17, no. 42, Oct. 2019, pp. 9313–20. Epmc, doi:10.1039/c9ob01702j. Full Text

Wicks, Sarah L., and Amanda E. Hargrove. “Fluorescent indicator displacement assays to identify and characterize small molecule interactions with RNA.Methods (San Diego, Calif.), vol. 167, Sept. 2019, pp. 3–14. Epmc, doi:10.1016/j.ymeth.2019.04.018. Full Text

Umuhire Juru, Aline, et al. “Understanding the Contributions of Conformational Changes, Thermodynamics, and Kinetics of RNA-Small Molecule Interactions.Acs Chemical Biology, vol. 14, no. 5, May 2019, pp. 824–38. Epmc, doi:10.1021/acschembio.8b00945. Full Text


Hargrove, A. E. Preface. Vol. 623, 2019, pp. xv–xvii. Scopus, doi:10.1016/S0076-6879(19)30266-6. Full Text

Padroni, Giacomo, et al. Differentiation and classification of RNA motifs using small molecule-based pattern recognition. Vol. 623, 2019, pp. 101–30. Epmc, doi:10.1016/bs.mie.2019.05.022. Full Text

Hargrove, Amanda E. Preface. Vol. 623, 2019, pp. xv–xvii. Pubmed, doi:10.1016/S0076-6879(19)30266-6. Full Text

Hargrove, Amanda E. “RNA Recognition.” RNA RECOGNITION, edited by A. E. Hargrove, vol. 623, ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD, 2019, pp. XV–XVII.