Faculty Profiles

Amanda Hargrove
Assistant Professor of Chemistry
Office: 
3219 French Science Center, Box 90346, Durham, NC 27708
Phone: 
(919) 660-1522
Fax: 
(919) 660-1605

Overview

Education:

NIH Postdoctoral Fellow, Chemistry, California Institute of Technology 2010 - 2013

Ph.D., University of Texas at Austin 2010

B.S., Trinity University 2004

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Eubanks, CS, and Hargrove, AE. "RNA Structural Differentiation: Opportunities with Pattern Recognition." Biochemistry 58.4 (January 2019): 199-213. Full Text

Patwardhan, NN, Cai, Z, Newson, CN, and Hargrove, AE. "Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA." Organic & Biomolecular Chemistry (November 23, 2018). Full Text

Donlic, A, Morgan, BS, Xu, JL, Liu, A, Roble, C, and Hargrove, AE. "Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold." Angewandte Chemie (International Ed. in English) 57.40 (October 2018): 13242-13247. Full Text

Morgan, BS, Forte, JE, and Hargrove, AE. "Insights into the development of chemical probes for RNA." Nucleic Acids Research 46.16 (September 2018): 8025-8037. Full Text

Donlic, A, and Hargrove, AE. "Targeting RNA in mammalian systems with small molecules." Wiley Interdisciplinary Reviews. Rna 9.4 (July 2018): e1477-null. (Review) Full Text

Eubanks, CS, and Hargrove, AE. "Sensing the impact of environment on small molecule differentiation of RNA sequences." Chemical Communications (Cambridge, England) 53.100 (December 2017): 13363-13366. Full Text

Morgan, BS, Forte, JE, Culver, RN, Zhang, Y, and Hargrove, AE. "Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands." Angewandte Chemie (International Ed. in English) 56.43 (October 2017): 13498-13502. Full Text

Patwardhan, NN, Ganser, LR, Kapral, GJ, Eubanks, CS, Lee, J, Sathyamoorthy, B, Al-Hashimi, HM, and Hargrove, AE. "Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR." Medchemcomm 8.5 (May 2017): 1022-1036. Full Text

Eubanks, CS, Forte, JE, Kapral, GJ, and Hargrove, AE. "Small Molecule-Based Pattern Recognition To Classify RNA Structure." Journal of the American Chemical Society 139.1 (January 2017): 409-416. Full Text

Pages