Faculty Profiles

Amanda Hargrove
Assistant Professor of Chemistry
Office: 
3219 French Science Center, Box 90346, Durham, NC 27708
Phone: 
(919) 660-1522
Fax: 
(919) 660-1605

Overview

Education:

NIH Postdoctoral Fellow, Chemistry, California Institute of Technology 2010 - 2013

Ph.D., University of Texas at Austin 2010

B.S., Trinity University 2004

Research Areas:
Synthesis, Biomolecular Structure and Function, Biological, Organic

Umuhire Juru, Aline, et al. “Understanding the Contributions of Conformational Changes, Thermodynamics, and Kinetics of RNA-Small Molecule Interactions..” Acs Chemical Biology, vol. 14, no. 5, May 2019, pp. 824–38. Epmc, doi:10.1021/acschembio.8b00945. Full Text

Wicks, Sarah L., and Amanda E. Hargrove. “Fluorescent indicator displacement assays to identify and characterize small molecule interactions with RNA..” Methods (San Diego, Calif.), Apr. 2019. Epmc, doi:10.1016/j.ymeth.2019.04.018. Full Text

Donlic, Anita, et al. “Corrigendum: Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold..” Angewandte Chemie (International Ed. in English), vol. 58, no. 17, Apr. 2019. Epmc, doi:10.1002/anie.201900875. Full Text

Eubanks, Christopher S., et al. “Visualizing RNA Conformational Changes via Pattern Recognition of RNA by Small Molecules..” Journal of the American Chemical Society, vol. 141, no. 14, Apr. 2019, pp. 5692–98. Epmc, doi:10.1021/jacs.8b09665. Full Text

Patwardhan, Neeraj N., et al. “Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA..” Organic & Biomolecular Chemistry, vol. 17, no. 7, Feb. 2019, pp. 1778–86. Epmc, doi:10.1039/c8ob02467g. Full Text

Eubanks, Christopher S., and Amanda E. Hargrove. “RNA Structural Differentiation: Opportunities with Pattern Recognition..” Biochemistry, vol. 58, no. 4, Jan. 2019, pp. 199–213. Epmc, doi:10.1021/acs.biochem.8b01090. Full Text

Donlic, Anita, et al. “Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold..” Angewandte Chemie (International Ed. in English), vol. 57, no. 40, Oct. 2018, pp. 13242–47. Epmc, doi:10.1002/anie.201808823. Full Text

Morgan, Brittany S., et al. “Insights into the development of chemical probes for RNA..” Nucleic Acids Research, vol. 46, no. 16, Sept. 2018, pp. 8025–37. Epmc, doi:10.1093/nar/gky718. Full Text

Donlic, Anita, and Amanda E. Hargrove. “Targeting RNA in mammalian systems with small molecules..” Wiley Interdisciplinary Reviews. Rna, vol. 9, no. 4, July 2018. Epmc, doi:10.1002/wrna.1477. Full Text

Eubanks, Christopher S., and Amanda E. Hargrove. “Sensing the impact of environment on small molecule differentiation of RNA sequences..” Chemical Communications (Cambridge, England), vol. 53, no. 100, Dec. 2017, pp. 13363–66. Epmc, doi:10.1039/c7cc07157d. Full Text

Pages

Hargrove, A. E. Preface. Vol. 623, 2019, pp. xv–xvii. Scopus, doi:10.1016/S0076-6879(19)30266-6. Full Text

Padroni, Giacomo, et al. Differentiation and classification of RNA motifs using small molecule-based pattern recognition.. Vol. 623, 2019, pp. 101–30. Epmc, doi:10.1016/bs.mie.2019.05.022. Full Text

Hargrove, Amanda E. Preface.. Vol. 623, 2019, pp. xv–xvii. Pubmed, doi:10.1016/S0076-6879(19)30266-6. Full Text