Faculty Profiles

Alvin L. Crumbliss
Alvin L. Crumbliss
University Distinguished Service Professor Emeritus
Office: 
2104 French Family Science Center, Box 90346, Durham, NC 27708-0354
Phone: 
(919) 660-1540
alvin.crumbliss@duke.edu
http://sites.duke.edu/crumbliss/
Research Interests: 

Dr. Crumbliss is interested in the function, reactivity and control of transition metals in biological systems. A major emphasis is investigations related to the biochemistry of iron. Through application of in vitro and ex vivo biophysical techniques the Crumbliss group is investigating iron trafficking mediated by proteins and low molecular weight iron carriers (siderophores) in bacterial and mammalian cells. This research is relevant to understanding iron bioavailability, oxidative stress, and the relationship between iron and human health and disease. The redox behavior of various native, mutant and engineered hemoglobins is also under investigation with respect to their role in oxidative stress, signaling and cooperative oxygen transport, and potential application as cell free blood substitutes.

Overview

Education:

Ph.D., Northwestern University 1968

B.A., Knox College 1964

Research Areas:
Biomolecular Structure and Function, Biological, Inorganic

Spasojevic, Ivan, et al. “Electrochemical Behavior of the Fe(III) Complexes of the Cyclic Hydroxamate Siderophores Alcaligin and Desferrioxamine E.” Inorg Chem, vol. 38, no. 3, Feb. 1999, pp. 449–54. Pubmed, doi:10.1021/ic980635n. Full Text

Bonaventura, C., et al. “Internal electron transfer between hemes and Cu(II) bound at cysteine beta93 promotes methemoglobin reduction by carbon monoxide.” The Journal of Biological Chemistry, vol. 274, no. 9, Feb. 1999, pp. 5499–507. Epmc, doi:10.1074/jbc.274.9.5499. Full Text

Taboy, C. H., et al. “Spectroelectrochemistry of heme proteins: effects of active-site heterogeneity on Nernst plots.” Bioelectrochemistry and Bioenergetics (Lausanne, Switzerland), vol. 48, no. 1, Feb. 1999, pp. 79–86. Epmc, doi:10.1016/s0302-4598(98)00236-0. Full Text

Kowall, T., et al. “Interpretation of activation volumes for water exchange reactions revisited: Ab initio calculations for Al3+, Ga3+, and In3+, and new experimental data.” Chemtracts, vol. 12, no. 2, Feb. 1999, pp. 102–09.

Spasojević, I., and A. L. Crumbliss. “Bulk liquid membrane transport of ferrioxamine B by neutral and ionizable carriers.” Journal of the Chemical Society  Dalton Transactions, no. 23, Dec. 1998, pp. 4021–27.

Caldwell, C. D., and A. L. Crumbliss. “Molecular Recognition of Ferrioxamine B by Host-Guest Complex Formation with Lasalocid A in Chloroform.” Inorganic Chemistry, vol. 37, no. 8, Dec. 1998, pp. 1906–12.

Kraiter, D. C., et al. “A Determination of the Reduction Potentials for Diferric and C- and N-Lobe Monoferric Transferrins at Endosomal pH (5.8).” Inorganic Chemistry, vol. 37, no. 5, Dec. 1998, pp. 964–68.

Batinić-Haberle, I., et al. “Lariat Ether Carboxylic Acids as Ionizable Hosts in the Second Coordination Sphere of the Siderophore Ferrioxamine B in Chloroform.” Inorganic Chemistry, vol. 37, no. 7, Dec. 1998, pp. 1438–45.

Urano, Y., et al. “Pronounced axial thiolate ligand effect on the reactivity of high-valent oxo-iron porphyrin intermediate.” Chemtracts, vol. 11, no. 5, May 1998, pp. 327–32.

Albrecht-Gary, A. M., and A. L. Crumbliss. “Coordination chemistry of siderophores: thermodynamics and kinetics of iron chelation and release.” Metal Ions in Biological Systems, vol. 35, Jan. 1998, pp. 239–327.

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