Faculty Profiles

Alvin L. Crumbliss
Alvin L. Crumbliss
University Distinguished Service Professor Emeritus
Office: 
2104 French Family Science Center, Box 90346, Durham, NC 27708-0354
Phone: 
(919) 660-1540
alvin.crumbliss@duke.edu
http://sites.duke.edu/crumbliss/
Research Interests: 

Dr. Crumbliss is interested in the function, reactivity and control of transition metals in biological systems. A major emphasis is investigations related to the biochemistry of iron. Through application of in vitro and ex vivo biophysical techniques the Crumbliss group is investigating iron trafficking mediated by proteins and low molecular weight iron carriers (siderophores) in bacterial and mammalian cells. This research is relevant to understanding iron bioavailability, oxidative stress, and the relationship between iron and human health and disease. The redox behavior of various native, mutant and engineered hemoglobins is also under investigation with respect to their role in oxidative stress, signaling and cooperative oxygen transport, and potential application as cell free blood substitutes.

Overview

Education:

Ph.D., Northwestern University 1968

B.A., Knox College 1964

Research Areas:
Biomolecular Structure and Function, Biological, Inorganic

Kowall, T., et al. “Interpretation of activation volumes for water exchange reactions revisited: Ab initio calculations for Al3+, Ga3+, and In3+, and new experimental data.” Chemtracts, vol. 12, no. 2, Feb. 1999, pp. 102–09.

Bonaventura, C., et al. “Internal electron transfer between hemes and Cu(II) bound at cysteine beta93 promotes methemoglobin reduction by carbon monoxide.” The Journal of Biological Chemistry, vol. 274, no. 9, Feb. 1999, pp. 5499–507. Epmc, doi:10.1074/jbc.274.9.5499. Full Text

Taboy, C. H., et al. “Spectroelectrochemistry of heme proteins: effects of active-site heterogeneity on Nernst plots.” Bioelectrochemistry and Bioenergetics (Lausanne, Switzerland), vol. 48, no. 1, Feb. 1999, pp. 79–86. Epmc, doi:10.1016/s0302-4598(98)00236-0. Full Text

Spasojević, I., and A. L. Crumbliss. “PH induced active ("Uphill") liquid membrane transport of ferrioxamine B by the ionizable ionophore lasalocid.” Inorganic Chemistry, vol. 38, no. 13, Jan. 1999, pp. 3248–50. Scopus, doi:10.1021/ic9813664. Full Text

Spasojević, I., and A. L. Crumbliss. “Bulk liquid membrane transport of ferrioxamine B by neutral and ionizable carriers.” Journal of the Chemical Society  Dalton Transactions, no. 23, Dec. 1998, pp. 4021–27. Scopus, doi:10.1039/a804391d. Full Text

Urano, Y., et al. “Pronounced axial thiolate ligand effect on the reactivity of high-valent oxo-iron porphyrin intermediate.” Chemtracts, vol. 11, no. 5, May 1998, pp. 327–32.

Bonaventura, C., et al. “Conformational fluctuations in deoxy hemoglobin revealed as a major contributor to anionic modulation of function through studies of the oxygenation and oxidation of hemoglobins A0 and Deer Lodge beta2(NA2)His --> Arg.” Biochemistry, vol. 37, no. 2, Jan. 1998, pp. 496–506. Epmc, doi:10.1021/bi971574s. Full Text

Ghio, A. J., et al. “The release of iron from different asbestos structures by hydrogen peroxide with concomitant O2 generation.” Biometals, vol. 11, no. 1, Jan. 1998, pp. 41–47. Pubmed, doi:10.1023/a:1009257323963. Full Text

Batinić-Haberle, I., et al. “Lariat Ether Carboxylic Acids as Ionizable Hosts in the Second Coordination Sphere of the Siderophore Ferrioxamine B in Chloroform.” Inorganic Chemistry, vol. 37, no. 7, Jan. 1998, pp. 1438–45. Scopus, doi:10.1021/ic970925o. Full Text

Caldwell, C. D., and A. L. Crumbliss. “Molecular Recognition of Ferrioxamine B by Host-Guest Complex Formation with Lasalocid A in Chloroform.” Inorganic Chemistry, vol. 37, no. 8, Jan. 1998, pp. 1906–12. Scopus, doi:10.1021/ic971038o. Full Text

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