Faculty Profiles

Alvin L. Crumbliss
Alvin L. Crumbliss
University Distinguished Service Professor Emeritus
Office: 
2104 French Family Science Center, Box 90346, Durham, NC 27708-0354
Phone: 
(919) 660-1540
alvin.crumbliss@duke.edu
http://sites.duke.edu/crumbliss/
Research Interests: 

Dr. Crumbliss is interested in the function, reactivity and control of transition metals in biological systems. A major emphasis is investigations related to the biochemistry of iron. Through application of in vitro and ex vivo biophysical techniques the Crumbliss group is investigating iron trafficking mediated by proteins and low molecular weight iron carriers (siderophores) in bacterial and mammalian cells. This research is relevant to understanding iron bioavailability, oxidative stress, and the relationship between iron and human health and disease. The redox behavior of various native, mutant and engineered hemoglobins is also under investigation with respect to their role in oxidative stress, signaling and cooperative oxygen transport, and potential application as cell free blood substitutes.

Overview

Education:

Ph.D., Northwestern University 1968

B.A., Knox College 1964

Research Areas:
Biomolecular Structure and Function, Biological, Inorganic

Tran, Duc T., et al. “Slow histidine H/D exchange protocol for thermodynamic analysis of protein folding and stability using mass spectrometry.” Analytical Chemistry, vol. 84, no. 3, Feb. 2012, pp. 1653–60. Epmc, doi:10.1021/ac202927p. Full Text

Crumbliss, A. L., and C. J. Parker Siburt. Iron Transport in Living Cells. Jan. 2012, pp. 483–549. Scopus, doi:10.1002/9781118165850.ch13. Full Text

Harrington, James M., et al. “Fe(III)-complexes of the tripodal trishydroxamate siderophore basidiochrome: potential biological implications.” Journal of Inorganic Biochemistry, vol. 105, no. 12, Dec. 2011, pp. 1670–74. Epmc, doi:10.1016/j.jinorgbio.2011.08.010. Full Text

Bonaventura, Celia, et al. “Steric factors moderate conformational fluidity and contribute to the high proton sensitivity of Root effect hemoglobins.” Biochimica Et Biophysica Acta, vol. 1814, no. 10, Oct. 2011, pp. 1261–68. Epmc, doi:10.1016/j.bbapap.2011.06.012. Full Text

Harrington, James M., et al. “Characterization of Fe(III) sequestration by an analog of the cytotoxic siderophore brasilibactin A: implications for the iron transport mechanism in mycobacteria.” Metallomics : Integrated Biometal Science, vol. 3, no. 5, May 2011, pp. 464–71. Epmc, doi:10.1039/c0mt00109k. Full Text

Miller, Marvin J., et al. “Design, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malaria.” Journal of the American Chemical Society, vol. 133, no. 7, Feb. 2011, pp. 2076–79. Epmc, doi:10.1021/ja109665t. Full Text

Tristani, E. M., et al. “Siderophore-redox active ionophore host-guest assemblies: A prototype for selective metal ion compartmentalization.” Inorganica Chimica Acta, vol. 363, no. 13, Oct. 2010, pp. 3611–15. Scopus, doi:10.1016/j.ica.2010.05.052. Full Text

Bonaventura, Celia, et al. “Extreme differences between hemoglobins I and II of the clam Lucina pectinalis in their reactions with nitrite.” Biochimica Et Biophysica Acta, vol. 1804, no. 10, Oct. 2010, pp. 1988–95. Epmc, doi:10.1016/j.bbapap.2010.06.016. Full Text

Harrington, James M., et al. “Synthesis and iron sequestration equilibria of novel exocyclic 3-hydroxy-2-pyridinone donor group siderophore mimics.” Inorganic Chemistry, vol. 49, no. 18, Sept. 2010, pp. 8208–21. Epmc, doi:10.1021/ic902595c. Full Text Open Access Copy

Parker Siburt, Claire J., et al. “Redox potentials of Ti(IV) and Fe(III) complexes provide insights into titanium biodistribution mechanisms.” Journal of Inorganic Biochemistry, vol. 104, no. 9, Sept. 2010, pp. 1006–09. Epmc, doi:10.1016/j.jinorgbio.2010.04.004. Full Text

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