Faculty Profiles

Alvin L. Crumbliss
Alvin L. Crumbliss
University Distinguished Service Professor Emeritus
Office: 
2104 French Family Science Center, Box 90346, Durham, NC 27708-0354
Phone: 
(919) 660-1540
alvin.crumbliss@duke.edu
http://sites.duke.edu/crumbliss/
Research Interests: 

Dr. Crumbliss is interested in the function, reactivity and control of transition metals in biological systems. A major emphasis is investigations related to the biochemistry of iron. Through application of in vitro and ex vivo biophysical techniques the Crumbliss group is investigating iron trafficking mediated by proteins and low molecular weight iron carriers (siderophores) in bacterial and mammalian cells. This research is relevant to understanding iron bioavailability, oxidative stress, and the relationship between iron and human health and disease. The redox behavior of various native, mutant and engineered hemoglobins is also under investigation with respect to their role in oxidative stress, signaling and cooperative oxygen transport, and potential application as cell free blood substitutes.

Overview

Education:

Ph.D., Northwestern University 1968

B.A., Knox College 1964

Research Areas:
Biomolecular Structure and Function, Biological, Inorganic

Crumbliss, A. L., and A. T. Poulos. “Kinetics of Oxidation of a Cuprous 2,2′,2″-Terpyridine Complex by Molecular Oxygen.” Inorganic Chemistry, vol. 14, no. 7, July 1975, pp. 1529–34. Scopus, doi:10.1021/ic50149a017. Full Text

Butterfield, D. A., et al. “Radical decay kinetics in ferrocytochrome c model membranes. A spin label study.” Journal of the American Chemical Society, vol. 97, no. 6, Mar. 1975, pp. 1388–93. Epmc, doi:10.1021/ja00839a018. Full Text

Crumbliss, A. L., and P. L. Gaus. “Synthesis and Characterization of Protonated Alkylcobaloximes and Related Compounds.” Inorganic Chemistry, vol. 14, no. 3, Mar. 1975, pp. 486–90. Scopus, doi:10.1021/ic50145a007. Full Text

Crumbliss, A. L., et al. “Preparation and X-ray crystal structure of a novel tetranuclear copper(I) ethylenethiourea cluster complex, μ4-ethylenethiourea-cyclo- tetrakis-μ-(ethylenethiourea)tetrakis[ethylenethioureacopper(I)] nitrate hexahydrate.” Journal of the Chemical Society, Chemical Communications, no. 14, Jan. 1974, pp. 545–46. Scopus, doi:10.1039/C39740000545. Full Text

Crumbliss, A. L., and P. L. Gaus. “The synthesis of neutral cyano bridged dicobaloximes.” Inorganic and Nuclear Chemistry Letters, vol. 10, no. 6, Jan. 1974, pp. 485–90. Scopus, doi:10.1016/0020-1650(74)80071-1. Full Text

Crumbliss, A. L., et al. “Isolation and characterization of chloro(ethyl) dimethylglyoximatodimethylglyoximecobalt(III) hydrate. A protonated cobaloxime.” Journal of the Chemical Society, Chemical Communications, no. 13, Dec. 1973, pp. 415–16. Scopus, doi:10.1039/C39730000415. Full Text

Crumbliss, A. L., and F. Basolo. “Isomeric Tetracyanoethylene Adducts of N,N'-Ethylenebis(acetylacetoniminato)cobalt(II).” Inorganic Chemistry, vol. 10, no. 8, Aug. 1971, pp. 1676–80. Scopus, doi:10.1021/ic50102a029. Full Text

Crumbliss, A. L., and W. K. Wilmarth. “Substitution Kinetics of Alkylbis(dimethylglyoximato)aquocoball(III) in Aqueous Solution1 Sir.” Journal of the American Chemical Society, vol. 92, no. 8, Apr. 1970, pp. 2593–94. Scopus, doi:10.1021/ja00711a088. Full Text

Crumbliss, A. L., and F. Basolo. “Monomeric Oxygen Adducts of N,N′-Ethylenebis(acetylacetoniminato) ligandcobalt (II). Preparation and Properties.” Journal of the American Chemical Society, vol. 92, no. 1, Jan. 1970, pp. 55–60. Scopus, doi:10.1021/ja00704a009. Full Text

Crumbliss, A. L., and F. Basolo. “Monomeric cobalt-oxygen complexes.” Science (New York, N.Y.), vol. 164, no. 3884, June 1969, pp. 1168–70. Epmc, doi:10.1126/science.164.3884.1168. Full Text

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