Faculty Profiles

Alvin L. Crumbliss
Alvin L. Crumbliss
University Distinguished Service Professor Emeritus
Office: 
2104 French Family Science Center, Box 90346, Durham, NC 27708-0354
Phone: 
(919) 660-1540
alvin.crumbliss@duke.edu
http://sites.duke.edu/crumbliss/
Research Interests: 

Dr. Crumbliss is interested in the function, reactivity and control of transition metals in biological systems. A major emphasis is investigations related to the biochemistry of iron. Through application of in vitro and ex vivo biophysical techniques the Crumbliss group is investigating iron trafficking mediated by proteins and low molecular weight iron carriers (siderophores) in bacterial and mammalian cells. This research is relevant to understanding iron bioavailability, oxidative stress, and the relationship between iron and human health and disease. The redox behavior of various native, mutant and engineered hemoglobins is also under investigation with respect to their role in oxidative stress, signaling and cooperative oxygen transport, and potential application as cell free blood substitutes.

Overview

Education:

Ph.D., Northwestern University 1968

B.A., Knox College 1964

Research Areas:
Biomolecular Structure and Function, Biological, Inorganic

Batinić-Haberle, I., et al. “Stereochemical factors affecting second-sphere co-ordination of ferrioxamine B with cis-syn-cis and cis-anti-cis isomers of dicyclohexano-18-crown-6 in chloroform and a comparison with alkali-metal and ammonium cations.” Journal of the Chemical Society, Dalton Transactions, no. 15, Dec. 1995, pp. 2503–08. Scopus, doi:10.1039/DT9950002503. Full Text

Faulkner, K. M., et al. “A spectroelectrochemical method for differentiation of steric and electronic effects in hemoglobins and myoglobins.” The Journal of Biological Chemistry, vol. 270, no. 23, June 1995, pp. 13604–12. Epmc, doi:10.1074/jbc.270.23.13604. Full Text

Batinić-Haberle, I., and A. L. Crumbliss. “Influence of the Anion on the Stability of Second-Sphere Coordination of Ferrioxamine B with cis-Dicyclohexano-18-crown-6 in Chloroform.” Inorganic Chemistry, vol. 34, no. 4, Feb. 1995, pp. 928–32. Scopus, doi:10.1021/ic00108a026. Full Text

Caudle, M. T., et al. “Dihydroxamic acid complexes of iron (III): ligand pKa and coordinated water hydrolysis constants.” Inorganica Chimica Acta, vol. 240, no. 1–2, Jan. 1995, pp. 519–25. Scopus, doi:10.1016/0020-1693(95)04577-5. Full Text

Schiffman, S. S., et al. “Detection thresholds of potassium salts are related to the molar conductivity of the anion.” Brain Research Bulletin, vol. 37, no. 6, Jan. 1995, pp. 623–26. Epmc, doi:10.1016/0361-9230(95)00054-i. Full Text

Ghio, A. J., et al. “Phagocyte-generated superoxide reduces Fe3+ to displace it from the surface of asbestos.” Archives of Biochemistry and Biophysics, vol. 315, no. 2, Dec. 1994, pp. 219–25. Epmc, doi:10.1006/abbi.1994.1493. Full Text

Caudle, M. T., et al. “A Monomer-to-Dimer Shift in a Series of 1:1 Ferric Dihydroxamates Probed by Electrospray Mass Spectrometry.” Inorganic Chemistry, vol. 33, no. 26, Dec. 1994, pp. 6111–15. Scopus, doi:10.1021/ic00104a020. Full Text

Caudle, M. T., et al. “Mechanistic Studies on the Dissociation of Mono- and Bimetallic 1:1 Ferric Dihydroxamate Complexes: Probing Structural Effects in Siderophore Dissociation Reactions.” Inorganic Chemistry, vol. 33, no. 21, Oct. 1994, pp. 4759–73. Scopus, doi:10.1021/ic00099a029. Full Text

Caudle, M. T., and A. L. Crumbliss. “Dissociation Kinetics of (N-Methylacetohydroxamato)iron(III) Complexes: A Model for Probing Electronic and Structural Effects in the Dissociation of Siderophore Complexes.” Inorganic Chemistry, vol. 33, no. 18, Aug. 1994, pp. 4077–85. Scopus, doi:10.1021/ic00096a037. Full Text

Batinić-Haberle, I., et al. “Hydrolysis of Ferrioxamine B in Aqueous Micellar Solution.” Inorganic Chemistry, vol. 33, no. 14, July 1994, pp. 3151–58. Scopus, doi:10.1021/ic00092a022. Full Text

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