Faculty Profiles

Alvin L. Crumbliss
Alvin L. Crumbliss
University Distinguished Service Professor Emeritus
Office: 
2104 French Family Science Center, Box 90346, Durham, NC 27708-0354
Phone: 
(919) 660-1540
alvin.crumbliss@duke.edu
http://sites.duke.edu/crumbliss/
Research Interests: 

Dr. Crumbliss is interested in the function, reactivity and control of transition metals in biological systems. A major emphasis is investigations related to the biochemistry of iron. Through application of in vitro and ex vivo biophysical techniques the Crumbliss group is investigating iron trafficking mediated by proteins and low molecular weight iron carriers (siderophores) in bacterial and mammalian cells. This research is relevant to understanding iron bioavailability, oxidative stress, and the relationship between iron and human health and disease. The redox behavior of various native, mutant and engineered hemoglobins is also under investigation with respect to their role in oxidative stress, signaling and cooperative oxygen transport, and potential application as cell free blood substitutes.

Overview

Education:

Ph.D., Northwestern University 1968

B.A., Knox College 1964

Research Areas:
Biomolecular Structure and Function, Biological, Inorganic

Dufour, M. N., et al. “Reaction of indoles with molecular oxygen catalyzed by metalloporphyrins.” Journal of Molecular Catalysis, vol. 7, no. 2, Jan. 1980, pp. 277–87. Scopus, doi:10.1016/0304-5102(80)85025-5. Full Text

Bruce, M., and A. Crumbliss. “Mechanism of Ligand Substitution on High-Spin Iron(III) by Hydroxamic Acid Chelators. Thermodynamic and Kinetic Studies on the Formation and Dissociation of a Series of Monohydroxamatoiron(III) Complexes.” Journal of the American Chemical Society, vol. 101, no. 21, Sept. 1979, pp. 6203–13. Scopus, doi:10.1021/ja00515a009. Full Text

Pitt, C. G., et al. “The selection and evaluation of new chelating agents for the treatment of iron overload.” The Journal of Pharmacology and Experimental Therapeutics, vol. 208, no. 1, Jan. 1979, pp. 12–18.

Ciskowski, J. M., and A. L. Crumbliss. “Synthesis and Characterization of Neutral Thiocyanato-and Selenocyanato-Bridged Cobaloximes.” Inorganic Chemistry, vol. 18, no. 3, Jan. 1979, pp. 638–46. Scopus, doi:10.1021/ic50193a023. Full Text

Gaus, P. L., and A. L. Crumbliss. “Synthesis and Characterization of Neutral Cyano-Bridged Dicobaloximes. (Alkyl)cobaloxime-μ-cyano-(ligand)cobaloxime.” Inorganic Chemistry, vol. 15, no. 9, Sept. 1976, pp. 2080–86. Scopus, doi:10.1021/ic50163a013. Full Text

Gaus, P. L., and A. L. Crumbliss. “Carbon-13 Nuclear Magnetic Resonance Spectra of Cyanocobaloximes Containing Carbon-13-Labeled Cyanide.” Inorganic Chemistry, vol. 15, no. 3, Mar. 1976, pp. 739–41. Scopus, doi:10.1021/ic50157a053. Full Text

Crumbliss, A. L., and P. L. Gaus. “Synthesis of Monocyanocobaloximes.” Inorganic Chemistry, vol. 15, no. 3, Mar. 1976, pp. 737–39. Scopus, doi:10.1021/ic50157a052. Full Text

Crumbliss, A. L., et al. “An introductory chemistry synthesis and kinetics experiment: Utilizing a low cost linear-log output spectrophotometer modification.” Journal of Chemical Education, vol. 53, no. 8, Jan. 1976, pp. 528–30. Scopus, doi:10.1021/ed053p528. Full Text

Crumbliss, A. L., and L. J. Gestaut. “Short communication Electronic Effects on the rate of Oxidation of Substituted Phenanthroline Complexes of Copper(I) by Molecular Oxygen.” Journal of Coordination Chemistry, vol. 5, no. 2, Jan. 1976, pp. 109–11. Scopus, doi:10.1080/00958977608075930. Full Text

Crumbliss, A. L., and P. L. Gaus. “Intermolecular Hydrogen Bonding in Protonated Diacidocobaloximes.” Inorganic Chemistry, vol. 14, no. 11, Nov. 1975, pp. 2745–47. Scopus, doi:10.1021/ic50153a030. Full Text

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