Faculty Profiles

Alvin L. Crumbliss
Alvin L. Crumbliss
University Distinguished Service Professor Emeritus
Office: 
2104 French Family Science Center, Box 90346, Durham, NC 27708-0354
Phone: 
(919) 660-1540
alvin.crumbliss@duke.edu
http://sites.duke.edu/crumbliss/
Research Interests: 

Dr. Crumbliss is interested in the function, reactivity and control of transition metals in biological systems. A major emphasis is investigations related to the biochemistry of iron. Through application of in vitro and ex vivo biophysical techniques the Crumbliss group is investigating iron trafficking mediated by proteins and low molecular weight iron carriers (siderophores) in bacterial and mammalian cells. This research is relevant to understanding iron bioavailability, oxidative stress, and the relationship between iron and human health and disease. The redox behavior of various native, mutant and engineered hemoglobins is also under investigation with respect to their role in oxidative stress, signaling and cooperative oxygen transport, and potential application as cell free blood substitutes.

Overview

Education:

Ph.D., Northwestern University 1968

B.A., Knox College 1964

Research Areas:
Biomolecular Structure and Function, Biological, Inorganic

Childers, J. W., et al. “SPECTRAL CHARACTERIZATION OF REDOX-ACTIVE PRUSSIAN BLUE ON METALLATED PLASMA POLYMER SURFACE MODIFIED CARBON ELECTRODES USING PHOTOTHERMAL DETECTION.” Journal De Physique (Paris), Colloque, vol. 44, no. 10, Jan. 1983. Scopus, doi:10.1051/jphyscol:1983645. Full Text

Wilmarth, W. K., et al. “Kinetics and mechanism of base aquation of chloroamminebis(dimethylglyoximato)cobalt(III) and chloropyridinebis(dimethylglyoximato)cobalt(III).” Coordination Chemistry Reviews, vol. 51, no. 2, Jan. 1983, pp. 225–42. Scopus, doi:10.1016/0010-8545(83)85013-9. Full Text

Crumbliss, A. L., et al. “Use of a Metal-Containing Plasma Polymer Coating to Prepare a Prussian Blue Surface Modified Electrode.” Inorganic Chemistry, vol. 22, no. 24, Jan. 1983, pp. 3541–48. Scopus, doi:10.1021/ic00166a012. Full Text

Morosoff, N., et al. “CHEMICAL PROPERTIES OF METALLATED PLASMA POLYMERS.” Organic Coatings and Applied Polymer Science Proceedings, vol. 47, Dec. 1982, pp. 318–22.

Brink, C. P., and A. L. Crumbliss. “Temperature-Dependent Acid Dissociation Constants (Ka, ΔHa, ΔSa) for a Series of Nitrogen-Substituted Hydroxamic Acids in Aqueous Solution.” Journal of Organic Chemistry, vol. 47, no. 7, Jan. 1982, pp. 1171–76. Scopus, doi:10.1021/jo00346a005. Full Text

Monzyk, B., and A. L. Crumbliss. “Kinetics and Mechanism of the Stepwise Dissociation of Iron(III) from Ferrioxamine B in Aqueous Acid.” Journal of the American Chemical Society, vol. 104, no. 18, Jan. 1982, pp. 4921–29. Scopus, doi:10.1021/ja00382a031. Full Text

Pinault, F. S., and A. L. Crumbliss. “Cobaloxime(II)-initiated coupling of α,α,α-trihalomethylbenzenes.” Journal of Organometallic Chemistry, vol. 215, no. 2, July 1981, pp. 229–39. Scopus, doi:10.1016/S0022-328X(00)80133-3. Full Text

Quin, L. D., et al. “Retention of stereospecific 31P chemical shift and coupling phenomena in a heterocyclic diphosphine upon complexation with a cobaloxime.” Inorganica Chimica Acta, vol. 53, no. C, Jan. 1981. Scopus, doi:10.1016/S0020-1693(00)84803-3. Full Text

Monzyk, B., and A. L. Crumbliss. “Kinetics and mechanism of the final stage of ferrioxamine B aquation in aqueous acid.” Inorganica Chimica Acta, vol. 55, no. C, Jan. 1981. Scopus, doi:10.1016/S0020-1693(00)90753-9. Full Text

Monzyk, B., and A. L. Crumbliss. “Acid Dissociation Constants (Ka) and Their Temperature Dependencies (AHa, ASa) for a Series of Carbon- and Nitrogen-Substituted Hydroxamic Acids in Aqueous Solution.” Journal of Organic Chemistry, vol. 45, no. 23, Jan. 1980, pp. 4670–75. Scopus, doi:10.1021/jo01311a024. Full Text

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