Faculty Profiles

Alvin L. Crumbliss
Alvin L. Crumbliss
University Distinguished Service Professor Emeritus
Office: 
2104 French Family Science Center, Box 90346, Durham, NC 27708-0354
Phone: 
(919) 660-1540
alvin.crumbliss@duke.edu
http://sites.duke.edu/crumbliss/
Research Interests: 

Dr. Crumbliss is interested in the function, reactivity and control of transition metals in biological systems. A major emphasis is investigations related to the biochemistry of iron. Through application of in vitro and ex vivo biophysical techniques the Crumbliss group is investigating iron trafficking mediated by proteins and low molecular weight iron carriers (siderophores) in bacterial and mammalian cells. This research is relevant to understanding iron bioavailability, oxidative stress, and the relationship between iron and human health and disease. The redox behavior of various native, mutant and engineered hemoglobins is also under investigation with respect to their role in oxidative stress, signaling and cooperative oxygen transport, and potential application as cell free blood substitutes.

Overview

Education:

Ph.D., Northwestern University 1968

B.A., Knox College 1964

Research Areas:
Biomolecular Structure and Function, Biological, Inorganic

Fish, L. L., and A. L. Crumbliss. “Comparison of the Kinetics, Mechanism, and Thermodynamics of Aqueous Iron(III) Chelation and Dissociation by Hydroxamic Oxo and Thio Acid Ligands.” Inorganic Chemistry, vol. 24, no. 14, July 1985, pp. 2198–204. Scopus, doi:10.1021/ic00208a018. Full Text

Crumbliss, A. L., et al. “Fourier transform infrared photothermal spectroscopic characterization of Prussian blue surface modified electrodes. Countercation effects.” Journal of Physical Chemistry, vol. 89, no. 3, Jan. 1985, pp. 482–88. Scopus, doi:10.1021/j100249a023. Full Text

Brink, C. P., et al. “Temperature-Dependent Acid Dissociation Constants (KaΔHa, ΔSa) for some C-Aryl Hydroxamic Acids: The Influence of C and N Substituents on Hydroxamate Anion Solvation in Aqueous Solution.” Journal of Organic Chemistry, vol. 50, no. 13, Jan. 1985, pp. 2277–81. Scopus, doi:10.1021/jo00213a016. Full Text

Morosoff, N., et al. “Transition metal containing plasma polymers.” Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films, vol. 3, no. 6, Jan. 1985, pp. 2098–101. Scopus, doi:10.1116/1.572931. Full Text

Morosoff, N., et al. “CHEMICAL PROPERTIES OF METALLATED PLASMA POLYMERS.” Applied Polymer Symposia, Dec. 1984, pp. 83–97.

Morosoff, N., et al. “Plasma polymerization of iron pentacarbonyl with C2 hydrocarbons.” Thin Solid Films, vol. 117, no. 1, July 1984, pp. 33–58. Scopus, doi:10.1016/0040-6090(84)90191-3. Full Text

Morosoff, N., et al. “Preparation of tris(η5-cyclopentadienylcobaltmonocarbonyl) cluster complex by a plasma technique.” Inorganica Chimica Acta, vol. 83, no. 2, Mar. 1984, pp. 137–41. Scopus, doi:10.1016/S0020-1693(00)82522-0. Full Text

Crumblis, A. L., et al. “Alkali metal cation effects in a prussian blue surface-modified electrode.” Inorganic Chemistry, vol. 23, no. 26, Jan. 1984, pp. 4701–08. Scopus, doi:10.1021/ic00194a057. Full Text

Brink, C. P., and A. L. Crumbliss. “Kinetics, mechanism, and thermodynamics of aqueous iron(III) chelation and dissociation: Influence of carbon and nitrogen substituents in hydroxamic acid ligands.” Inorganic Chemistry, vol. 23, no. 26, Jan. 1984, pp. 4708–18. Scopus, doi:10.1021/ic00194a058. Full Text

Monzyk, B., and A. L. Crumbliss. “Factors that influence siderophoremediated iron bioavailability: catalysis of interligand iron (III) transfer from ferrioxamine B to EDTA by hydroxamic acids.” Journal of Inorganic Biochemistry, vol. 19, no. 1, Aug. 1983, pp. 19–39. Epmc, doi:10.1016/0162-0134(83)85010-7. Full Text

Pages