Faculty Profiles

Alvin L. Crumbliss
Alvin L. Crumbliss
University Distinguished Service Professor Emeritus
Office: 
2104 French Family Science Center, Box 90346, Durham, NC 27708-0354
Phone: 
(919) 660-1540
alvin.crumbliss@duke.edu
http://sites.duke.edu/crumbliss/
Research Interests: 

Dr. Crumbliss is interested in the function, reactivity and control of transition metals in biological systems. A major emphasis is investigations related to the biochemistry of iron. Through application of in vitro and ex vivo biophysical techniques the Crumbliss group is investigating iron trafficking mediated by proteins and low molecular weight iron carriers (siderophores) in bacterial and mammalian cells. This research is relevant to understanding iron bioavailability, oxidative stress, and the relationship between iron and human health and disease. The redox behavior of various native, mutant and engineered hemoglobins is also under investigation with respect to their role in oxidative stress, signaling and cooperative oxygen transport, and potential application as cell free blood substitutes.

Overview

Education:

Ph.D., Northwestern University 1968

B.A., Knox College 1964

Research Areas:
Biomolecular Structure and Function, Biological, Inorganic

Chaubet, F., et al. “The design of magnetic resonance contrast agents: New iron (III) dihydroxamate complexes.” Tetrahedron Letters, vol. 31, no. 40, Jan. 1990, pp. 5729–32. Scopus, doi:10.1016/S0040-4039(00)97943-7. Full Text

Crumbliss, A. L., and J. M. Garrison. “A Comparison of Some Aspects of the Aqueous Coordination Chemistry of Aluminum(lll) and Iron(lll).” Comments on Inorganic Chemistry, vol. 8, no. 1–2, Sept. 1988, pp. 1–26. Scopus, doi:10.1080/02603598808048670. Full Text

Mark Garrison, J., and A. L. Crumbliss. “Experimental Determination of the 27Al NMR Quadrupole Coupling Constant of the Hexaaquoaluminum Ion in Aqueous Perchloric Acid and Mixed Acetone-Aqueous Perchloric Acid Solution.” Inorganic Chemistry, vol. 27, no. 17, Aug. 1988, pp. 3058–60. Scopus, doi:10.1021/ic00290a033. Full Text

Crumbliss, A. L., et al. “Preparation and activity of carbonic anhydrase immobilized on porous silica beads and graphite rods.” Biotechnology and Bioengineering, vol. 31, no. 8, May 1988, pp. 796–801. Epmc, doi:10.1002/bit.260310806. Full Text

Garrison, J. M., and A. L. Crumbliss. “Hydroxamic Acid Ligand-Exchange Kinetics at Hexaaquoaluminum Ion.” Inorganic Chemistry, vol. 26, no. 22, Nov. 1987, pp. 3660–64. Scopus, doi:10.1021/ic00269a009. Full Text

L. Crumbliss, A., et al. “Synthesis and characterization of iron(llI) chelating analogues of siderophores on organic solid supports.” Inorganica Chimica Acta, vol. 133, no. 2, Oct. 1987, pp. 281–87. Scopus, doi:10.1016/S0020-1693(00)87780-4. Full Text

Mark Garrison, J., and A. L. Crumbliss. “Kinetics and mechanism of aluminum(III)/siderophore ligand exchange: mono(deferriferrioxamine B)aluminum(III) formation and dissociation in aqueous acid solution.” Inorganica Chimica Acta, vol. 138, no. 1, Jan. 1987, pp. 61–65. Scopus, doi:10.1016/S0020-1693(00)81182-2. Full Text

Crumbliss, A. L., et al. “The electrochemistry of hexacyanoruthenate at carbon electrodes and the use of ruthenium compounds as mediators in the glucose/glucose oxidase system.” Journal of Electroanalytical Chemistry, vol. 206, no. 1–2, July 1986, pp. 327–31. Scopus, doi:10.1016/0022-0728(86)90280-9. Full Text

Crumbliss, A. L., et al. “The synthesis, x-ray crystal structure, and solution characterization of a bis(diphosphine)-bridged dirhodium(I) complex containing a Rh2P4 six-membered ring.” Journal of the Chemical Society, Dalton Transactions, no. 9, Jan. 1986, pp. 1895–99. Scopus, doi:10.1039/DT9860001895. Full Text

Crumbliss, A. L., et al. “Retention of phosphorus configuration on forming irontetracarbonyl complexes with phosphines in the 9-phosphabicyclo[4.2.1]nonatriene and 7-phosphanorbornene systems.” Tetrahedron Letters, vol. 27, no. 8, Jan. 1986, pp. 889–92. Scopus, doi:10.1016/S0040-4039(00)84129-5. Full Text

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