Faculty Profiles

Alvin L. Crumbliss
Alvin L. Crumbliss
University Distinguished Service Professor Emeritus
Office: 
2104 French Family Science Center, Box 90346, Durham, NC 27708-0354
Phone: 
(919) 660-1540
alvin.crumbliss@duke.edu
http://sites.duke.edu/crumbliss/
Research Interests: 

Dr. Crumbliss is interested in the function, reactivity and control of transition metals in biological systems. A major emphasis is investigations related to the biochemistry of iron. Through application of in vitro and ex vivo biophysical techniques the Crumbliss group is investigating iron trafficking mediated by proteins and low molecular weight iron carriers (siderophores) in bacterial and mammalian cells. This research is relevant to understanding iron bioavailability, oxidative stress, and the relationship between iron and human health and disease. The redox behavior of various native, mutant and engineered hemoglobins is also under investigation with respect to their role in oxidative stress, signaling and cooperative oxygen transport, and potential application as cell free blood substitutes.

Overview

Education:

Ph.D., Northwestern University 1968

B.A., Knox College 1964

Research Areas:
Biomolecular Structure and Function, Biological, Inorganic

Wirgau, Joseph I., and Alvin L. Crumbliss. “Carrier-facilitated bulk liquid membrane transport of iron(III)-siderophore complexes utilizing first coordination sphere recognition.” Inorganic Chemistry, vol. 42, no. 18, Sept. 2003, pp. 5762–70. Epmc, doi:10.1021/ic034157e. Full Text

Kachadourian, Remy, et al. “Synthesis and in vitro antioxidant properties of manganese(III) beta-octabromo-meso-tetrakis(4-carboxyphenyl)porphyrin.” Journal of Inorganic Biochemistry, vol. 95, no. 4, July 2003, pp. 240–48. Epmc, doi:10.1016/s0162-0134(03)00135-1. Full Text

Gabricević, Mario, and Alvin L. Crumbliss. “Kinetics and mechanism of iron(III)-nitrilotriacetate complex reactions with phosphate and acetohydroxamic acid.” Inorganic Chemistry, vol. 42, no. 13, June 2003, pp. 4098–101. Epmc, doi:10.1021/ic026281o. Full Text

Dhungana, Suraj, et al. “Iron chelation properties of an extracellular siderophore exochelin MN.” Journal of the American Chemical Society, vol. 125, no. 25, June 2003, pp. 7654–63. Epmc, doi:10.1021/ja029578u. Full Text

Dhungana, Suraj, et al. “The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin.” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 7, Apr. 2003, pp. 3659–64. Epmc, doi:10.1073/pnas.0536897100. Full Text

Dhungana, Suraj, et al. “Fe(III) coordination properties of a new saccharide-based exocyclic trihydroxamate analogue of ferrichrome.” Inorganic Chemistry, vol. 42, no. 1, Jan. 2003, pp. 42–50. Epmc, doi:10.1021/ic025647u. Full Text

Boukhalfa, Hakim, and Alvin L. Crumbliss. “Chemical aspects of siderophore mediated iron transport.” Biometals : An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine, vol. 15, no. 4, Dec. 2002, pp. 325–39. Epmc, doi:10.1023/a:1020218608266. Full Text

Bonaventura, Celia, et al. “Heme redox properties of S-nitrosated hemoglobin A0 and hemoglobin S: implications for interactions of nitric oxide with normal and sickle red blood cells.” J Biol Chem, vol. 277, no. 17, Apr. 2002, pp. 14557–63. Pubmed, doi:10.1074/jbc.M107658200. Full Text

Wirgau, Joseph I., et al. “Thermodynamics, kinetics, and mechanism of the stepwise dissociation and formation of Tris(L-lysinehydroxamato)iron(III) in aqueous acid.” Inorg Chem, vol. 41, no. 6, Mar. 2002, pp. 1464–73. Pubmed, doi:10.1021/ic0109795. Full Text

Taboy, Céline H., et al. “Anaerobic oxidations of myoglobin and hemoglobin by spectroelectrochemistry.” Methods in Enzymology, vol. 353, Jan. 2002, pp. 187–209. Epmc, doi:10.1016/s0076-6879(02)53048-2. Full Text

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