Faculty Profiles

Alvin L. Crumbliss
Alvin L. Crumbliss
University Distinguished Service Professor Emeritus
Office: 
2104 French Family Science Center, Box 90346, Durham, NC 27708-0354
Phone: 
(919) 660-1540
alvin.crumbliss@duke.edu
http://sites.duke.edu/crumbliss/
Research Interests: 

Dr. Crumbliss is interested in the function, reactivity and control of transition metals in biological systems. A major emphasis is investigations related to the biochemistry of iron. Through application of in vitro and ex vivo biophysical techniques the Crumbliss group is investigating iron trafficking mediated by proteins and low molecular weight iron carriers (siderophores) in bacterial and mammalian cells. This research is relevant to understanding iron bioavailability, oxidative stress, and the relationship between iron and human health and disease. The redox behavior of various native, mutant and engineered hemoglobins is also under investigation with respect to their role in oxidative stress, signaling and cooperative oxygen transport, and potential application as cell free blood substitutes.

Overview

Education:

Ph.D., Northwestern University 1968

B.A., Knox College 1964

Research Areas:
Biomolecular Structure and Function, Biological, Inorganic

Dhungana, S., et al. “Fe(III) coordination properties of two new saccharide-based enterobactin analogues: methyl 2,3,4-tris-O-[N-[2,3-di(hydroxy)benzoyl-glycyl]-aminopropyl]-alpha-D-glucopyranoside and methyl 2,3,4-tris-O-[N-[2,3-di-(hydroxy)-benzoyl]-aminopropyl]-alpha-D-glucopyranoside.” Inorganic Chemistry, vol. 40, no. 27, Dec. 2001, pp. 7079–86. Epmc, doi:10.1021/ic0104003. Full Text

Summers, J. S., et al. “31P NMR probes of chemical dynamics: paramagnetic relaxation enhancement of the (1)H and (31)P NMR resonances of methyl phosphite and methylethyl phosphate anions by selected metal complexes.” Inorganic Chemistry, vol. 40, no. 26, Dec. 2001, pp. 6547–54. Epmc, doi:10.1021/ic010728w. Full Text

Nguyen-Van-Duong, M. K., et al. “Synthesis, ligand pK(a), and Fe(III) complexation constants for a series of bipodal dihydroxamic acids.” Inorg Chem, vol. 40, no. 23, Nov. 2001, pp. 5948–53. Pubmed, doi:10.1021/ic0103143. Full Text

Trzaska, S. M., et al. “Optimization of the lariat ether carboxylic acid host structure for ferrioxamine B: demonstration of a second coordination shell chelate effect.” Inorganic Chemistry, vol. 40, no. 23, Nov. 2001, pp. 5823–28. Epmc, doi:10.1021/ic010095l. Full Text

Olmstead, E. G., et al. “Use of SDS micelles to stabilize a ternary intermediate in the reaction of ferrioxamine B and 1,10-phenanthroline.” Inorganic Chemistry, vol. 40, no. 21, Oct. 2001, pp. 5420–27. Epmc, doi:10.1021/ic0008621. Full Text

Dhungana, S., et al. “Crystal structure of ferrioxamine B: a comparative analysis and implications for molecular recognition.” Journal of Biological Inorganic Chemistry : Jbic : A Publication of the Society of Biological Inorganic Chemistry, vol. 6, no. 8, Oct. 2001, pp. 810–18. Epmc, doi:10.1007/s007750100259. Full Text

Flaherty, M., and A. L. Crumbliss. “Electron-induced inversion of helical chirality in copper complexes of N,N-dialkylmethionines.” Chemtracts, vol. 14, no. 5, Aug. 2001, pp. 237–42.

Dhungana, S., and A. L. Crumbliss. “Microbial iron transport via a siderophore shuttle: A membrane ion transport paradigm.” Chemtracts, vol. 14, no. 5, Aug. 2001, pp. 258–65.

Boukhalfa, H., and A. L. Crumbliss. “Kinetics and mechanism of a catalytic chloride ion effect on the dissociation of model siderophore hydroxamate-iron(III) complexes.” Inorganic Chemistry, vol. 40, no. 17, Aug. 2001, pp. 4183–90. Epmc, doi:10.1021/ic010050k. Full Text

Taboy, C. H., et al. “Fe3+ coordination and redox properties of a bacterial transferrin.” The Journal of Biological Chemistry, vol. 276, no. 4, Jan. 2001, pp. 2719–24. Epmc, doi:10.1074/jbc.m004763200. Full Text

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