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James Harrington, PhD '10 is currently a Research Chemist in RTI International’s Discovery Sciences (DS). In this capacity, he contributes to development of environmental exposure research and other strategic areas of interest to RTI’s Center for Analytical Sciences (AS). He has also contributed to bioanalytical research projects for the National Toxicology Program (NTP) in the area of metallomics and inorganic speciation, and development of the pharmaceutical heavy metals testing program at RTI. Dr. Harrington has previously performed research with the U.S. Environmental Protection Agency (EPA) on trace metal bioavailability in contaminated soils and on small molecule–metal interactions during his postdoctoral and doctoral studies. He has several publications in the areas of inorganic analytical methods and biogeochemistry of trace metals in the environment. His research interests include bioinorganic chemistry, environmental health, and analytical method development
Melanie Silinski, PhD '03 is a Senior Research Chemist in the Discovery Sciences group at RTI International. In this capacity, she performs chemical analysis and supervises the daily activities of professional, technical, and clerical staff who work on projects that involve handling of chemicals. She serves as Task Leader for the National Toxicology Program (NTP) Chemistry Services project, which includes chemical characterization, analysis of dosage formulations, and analysis of biological samples from toxicology studies. Dr. Silinski has expertise in mass spectrometry (MS) and chromatography with applications in drug discovery and development, from early exploratory research through Investigational New Drugs (INDs). She specializes in method development and the quantitative analysis of drug substances in biological matrices, as well as structural elucidation and metabolite identification using accurate mass spectrometric and tandem mass spectrometric techniques. She is experienced in writing reports for toxicology; absorption, distribution, metabolism, and excretion (ADME); and chemistry, manufacturing, and controls (CMC) sections of an IND application. Dr. Silinski reviews data and reports and regularly conducts Good Laboratory Practice (GLP) studies for government and industrial clients.
Ian Stewart, PhD '16 is currently a Research Chemist 1 in the Engineered Systems group at RTI International. He has a background in materials chemistry, specifically oxidation-resistant metal nanomaterials for electronic applications. In the Engineered Systems group, Dr. Stewart is exploring spray-dried, inhalable drugs for the treatment of tuberculosis and other airway pathogens as well as micro-particle and nanoparticle synthesis for enhanced oil and gas recovery. Previously, he contributed his technical expertise to a variety of projects, including hydrophobic and oleophobic textile coatings, water sanitation in developing areas, degradable epoxy formulation, and polymer nanoparticle synthesis.