New Antibiotics from Nature's Chemical Inventory
Professor Timothy A. Wencewicz (Washington University in St. Louis, Department of Chemistry)
Host: Professor Kathy Franz.
Tuesday, September 11, 2018 - 11:40am to 1:10pm
Location: French Family Science Center 2237
Rosenthal, Janet

Link for Professor Wencewicz

Abstract:  A contemporary approach to antibiotic drug discovery in academics will be presented as vignettes on strategies ongoing in the Wencewicz lab. Topics include checkpoint inhibitors of nitrogen metabolism (bacteriostatic agents), disruptors of iron acquisition (antivirulence agents), inhibitors of emerging resistance enzymes (adjuvant therapies), and completely novel antibacterial agents. Emphasis will be placed on the elucidation of molecular mechanisms and the use of natural products and synthetic variants as chemical probes and lead scaffolds. Despite our entry into the era of antibiotic resistance, an argument will be made that the future is bright for antibiotics thanks to Nature’s rich chemical inventory.