Events

Emerging nanophotonic platforms for infectious disease diagnostics: Re-imagining the conventional microbiology toolkit

Wednesday, October 21, 2020 - 12:00pm to 1:00pm

Speaker: 
Dr. Jennifer A. Dionne

We present our research controlling light at the nanoscale for infectious disease diagnostics, including detecting bacteria at low concentration, sensing COVID antibodies and antigens, and visualizing in-vivo inter-cellular forces. First, we combine Raman spectroscopy and deep learning to accurately classify bacteria by both species and antibiotic resistance in a single step. We design a convolutional neural network (CNN) for spectral data and train it to identify 30 of the most common bacterial strains from single-cell Raman spectra, achieving antibiotic treatment identification accuracies exceeding 99% and species identification accuracies similar to leading mass spectrometry identification techniques. Our combined Raman-CNN system represents a proof-of-concept for rapid, culture-free identification of bacterial isolates and antibiotic resistance.

Location: 
WebEx
Contact: 
Tyson, Quiana
660-5263
Sponsor: 
Pratt School of Engineering
Co-sponsors: 
Chemistry
Duke Materials Initiative
Electrical and Computer Engineering (ECE)
Mechanical Engineering and Materials Science (MEMS)
Physics
University Program in Materials Science and Engineering (MatSci)