Catalyst-Controlled Site-Selective and Enantioselective C-H Functionalization
Professor Huw Davies (Emory University, Department of Chemistry)
Host: Professor Steve Malcolmson
Tuesday, October 23, 2018 - 1:40pm to 3:10pm
Location: French Family Science Center 2231
Rosenthal, Janet

Link for Professor Davies

Abstract:  The development of practical methods for site selective C-H functionalization is of intense current interest. This presentation will describe a collaborative approach towards achieving new C-H functionalization strategies and our recent advances in the C-H insertion chemistry of donor/acceptor-substituted carbenoids. A series of chiral dirhodium catalysts have been developed for this chemistry and they are capable of controlling which C-H bond is functionalized.1,2 The application of these new synthetic strategies to the synthesis of natural products and pharmaceutical targets will be described.

1. Liao, K.; Negretti, S.; Musaev, D. G.; Bacsa, J.; Davies, H. M. L. Nature, 2016, 533, 230.

2. Liao, K.; Pickel, T. C.; Boyarskikh, V.; Bacsa, J.; Musaev, D.G.; Davies, H .M. L. Nature, 2017, 551, 609.